CFL (a British sofa company) have parodied this trope to extremes in their adverts with a Giantess.
A commercial for Pepto-Bismol had various kaiju and a 50-Foot Woman doing the "nausea, heartburn, indigestion" dance. Do we really want to consider the implications of giant beings with diarrhea?
Lee's Dungarees in their "Don't flinch." campaign had the "90-foot-Babe" Natalia Adarvez walking through a city, stepping on a Taxi, ripping power lines, towards a high-rise (or so it seems for the normal-sized peeps) where she picks out the window of a nice young man (the size of her finger) and gives him her phone number. Written on a billboard. With a broom. He, wearing Lee's Dungarees, doesn't flinch.
Inverted in some Direc TV ads, in which the multi-zillionaire spokesman has a pet giraffe less than 2' tall.
Ho, ho, ho, Green Giant frozen veggies!
Anime and Manga
Though not all measure up to Fifty feet, the Awakened Beings of Claymore are all fairly massive, the smallest standing at least 18-20 feet.
One episode of Mon Colle Knights is specifically titled "Attack of the 50-Foot Lovestar" (for the dub anyway), and has the normally fist-sized Lovestar grow huge after drinking some water near a farming village.
Episode 3 of the OAV Armored Troopers J-Pheonix PF Lips Team features a giant android girl named Kokoro chained to a cave wall. Needless to say, this episode focuses on two of the main characters helping to set her free.
Episode 30 of Keroro Gunsou introduced the Flash Spoon, a device that could make its user grow to enormous size. In the first half of episode 57, Keroro uses it to one-up Viper the Elder when the villain grows to giant size in a last-ditch effort at beating the Keroro Platoon. In the second half of the episode, a trip to the Nishizawa Group's private island (while waiting for the effects of the Flash Spoon on Keroro to wear off) results in a cuttlefish, a crab, and a turtle being turned into giant monsters by the spoon, while the rest of the cast also grows in an effort to stop them (except Dororo, who doesn't get his hands on the Flash Spoon until the batteries have run out).
The same thing happened in the dub, only it was called SpoonWow (made in Germany, you know the Germans always make good stuff).
Digimon is replete with examples of this, with several of the good guy and Big Bad title creatures taking on titanic proportions at one time or another.
You don't really get the sense of scale until you see Breetai fighting against Rick and Max... while they're still in their Valkyries.
... and he's still taller than them! Breetai was a big Zentran, though (if the average Zentran warrior's 30ft. is equivalent to a 6' human, Breetai's easily 6'7" to 7' proportionally); most other Zentron and Maltron are as big or slightly smaller than a full Batroid-form Valkyrie.
Further to the above, in the second TV sequel to SDF Macross, Macross Frontier, the trope is gleefully subverted as the Zentraedi have become part of accepted human society... and many of them still spend most of their times as 10-meter-tall people. Who still do simple stuff like farming. A highlight is two of the main characters hanging out with a Zentraedi support character at a mixed-size mall... and in order to be at eye-level with her, the mains are on a third-story balcony.
Though this seems to be rare. Macross 7 had no full size Zentraedi other than Exedol, and the Zentraedi exclusive Macross 5 fleet had none either. Zentraedi living at full size is apparently so rare that even Mylene Jenius, half Zentraedi herself, had never met one and was shocked to do so.
There's also Mylene's sister Emilia, who must have macronised herself only recently, since she was not only born human-sized, but Mylene was surprised to see her at that size when they met up again.
Which makes sense since being probably dozens of times a normal humans mass they'd use dozens of times a normal humans resources in food, air, and space rather valuable commodities in a self contained environment like say... a space ship. (let's not even get into who thought 50 foot tall astronauts was a good idea to begin with...)
Another time involved an amusement park island with Pokémon-shaped automatons that were several times the natural size of the critters they emulated - and the cast was stuck ON the island for the duration of the episode.
The giant tribal marked Alakazam and Gengar, and the giant similarly marked Jigglypuff Ash and Co. have to summon to sing them back into containment.
The episode where a Tentacruel grows to a huge size and destroys a city. Misty talks it down and convinces him and his goes back into the ocean. Later in the series, Tentacruel is shown to be, in reality, a fraction of the size.
The plot for UG♥Ultimate Girls. Three High School girls grow to 100 foot stature, then fight the monster of the week. Lather, rinse, repeat. However, subverting the Magic Pants trope is the whole point of the show.
The anime of Cardcaptor Sakura featured this with (what else?) the Big Card, whose most malign effect was visited upon a cat (it seemed perfectly content at schoolbus-size.) However, the Big Card was needed in that same episode to fight the giant dragon, which Sakura's friend was describing in the book form of the Create card, and which was preparing to attack Toemeda. Sakura grew to giant size to fight the dragon, and, miraculously, no one noticed.
In Ranma ˝, the forest of Ryugenzawa is home to a variety of exotic animals, such as koalas and platypuses, who have grown to titanic size (think "rabbits the size of grizzlies" and "flying squirrels the size of fighter jets") due to the magical properties of the Water of Life —itself a product of the magical moss that grows on the snout of the mountain-sized Yamata No Orochi.
In one damnation sequence from Jigoku Shoujo Mitsuganae, both Enma Ai and Kikuri are super-sized. They're mocking the victim's desire to be a "big shot".
Early on in Violinist of Hameln, the Demon King Drum assumes his true form —as a colossal, multiheaded dragon— and attacks the royal city of Sforzendo. At one point during the battle, Hamel proposes magically enlarging Flute so she engages Drum in a Kaiju battle, but is shot down immediately when they realize the equally-colossal upskirt view she'd give the whole city.
The very first scene of the series is of a giant Nine Tailed Demon Fox attacking the Hidden Leaf Village then being magically sealed inside the title character. We are later introduced to the other 8 Bijuu demons, all of which are gigantic in their own right.
Summoning Jutsu allows you to call forth giant beasts to attack enemies on your behalf, providing you have a contract with them. The actual size varies both from species to species and creature to creature, from normal sized dogs to "Boss" Snakes, Toads and Slugs that tower over tall buildings.
One of the Akimichi clan's abilities is the ability to grow to an incredible height. It's firstly demonstrated by Chouji's father Chouza, who turns into a giant and stomps on enemy ninja, and then by Chouji himself in the fight against Jirobo where he becomes so huge, his body occupies a clearing.
The purpose of Pein's Animal Path is to invoke this trope.
Jungle De Ikou ends with Mii turning into a giantess to stop Ongo from destroying the world.
Some of the Mushishi creatures-of-the-episode were quite large. The dying swamp, in particular.
Mana Eimiya, the titular Super-Dreadnought Girl, stands at 49M and 46CM and fights alien monsters of comparable size.
Mai-Otome essentially qualifies for this in the late episodes, when Nina Wong uses the Harmonium and grows into a several-hundred-foot-tall shadowy version of herself. The physical nature of the transformation/manifestation is debatable, but cities get crushed, hinting at plenty of mass.
Most of the Akuma in D.Gray-Man are roughly human-sized, but when a ton of level 3s are combined, they turn into a skyscraper-sized black giant of death referred to as a level 3.5. Naturally, one of them wound up fighting General Tiedoll, who turned his Innocence into a woodenmecha to fight it.
One of 007's abilities in Cyborg 009, though he only used it once when he and other cyborgs were under attack of cyborg animals.
In One Piece, this is the essence of Luffy'sGear3. Although he hasn't turned into a full-sized giant as of yet, he can expand parts of his body to the point of outclassing regular giants - who themselves measure at least 200 feet.
One of Keima's captured targets in The World God Only Knows grew enormous due to her desire to become "bigger" than a dojo leader.
Saiyans in Dragon Ball Z have the ability to turn into giant were-monkeys during the full moon if they have a tail. Piccolo and a one time villain from one of the movies, Slug, have also displayed the ability to make themselves grow to gigantic sizes.
Regular Titans in Attack on Titan are about this size, although there are a few even larger ones that are so tall they can look over the 50 meter (about 164 feet) high walls the remnants of humanity built to keep them out.
Also some who are much smaller (the smallest Titans average at about "just" three metres), who mostly hang around the larger ones for scraps or get into places too cramped for bigger Titans (meaning there are pretty much no safe hiding spaces).
Let's not forget Gurren Lagann. It went from the 50 ft tall variety in the beginning all the way to the size of a galaxy! What can you do when your opponent is also that size? Obviously you throw said galaxies at them.
Has happened to nearly every major character in The DCU at least once during the Silver Age. Jimmy Olsen's transformation into Turtle-Man is perhaps the most ridiculous example.
A number of comic book characters have this as their special power.
On the DC side, there's Atom Smasher (formerly of the JSA), the villainess Giganta, and Apache Chief from Superfriends, later reimagined as Longshadow on Justice League. Atom Smasher is somewhat unique in that his powers are more limited than most examples — his maximum height is well below 50 feet, probably closer to 30.
DC also has Elasti-Girl of the Doom Patrol who has straight growth (and shrinking) as her power as opposed to the Rubber Man powers her name would normally suggest.
Also from DC, the Legion of Super-Heroes has Colossal Boy. (In the latest reboot of the series, he insists he should be called "Micro Lad", as he's naturally 50 feet tall and has shrinking powers.) A previous version of the Legion had Shrinking Violet gain growth powers and call herself "Leviathan".
One of Superman's Silver Age enemies was Titano the Super Ape, a giant gorilla with Kryptonite vision. Also, the previously-mentioned Jimmy Olsen, Giant Turtle Boy.
In the Buffy the Vampire Slayer: Season Eight comics, Dawn is turned into a giant, presumably as an effect of losing her virginity to a "thricewise" but actually due to cheating on the thricewise with his roommate, so he cursed her in retribution.
One issue◊ of Spider-Girl, in a clear parody of the whole thing, has a cover with the heroine, grown to ridiculous size, with her parents in the foreground throwing out lines that would have been on any Silver Age Superman cover: "She may be a 50 foot monster, but she's still our daughter!" In the actual issue, this turned out to be part of a Lotus-Eater Machine a villain stuffed her into.
AC Comics, in general, has nearly half of its female characters able to turn into giantesses. This is explicitly Fanservice; their first giantess character was so popular that they ran with it. In particular Tara Freemont and Garganta of Femforce have this as their superpower.
Actually semi-justified in Manhattan's case; he rebuilt a body for himself after the accident, so the fact that he made it human-sized is largely nostalgia/convenience.
The National Lampoon did a comic-book parody of the genre called "Attack of the Sizeable Beasts", where a well-intentioned scientist's growth-hormone test animals get loose. Not monstrously big, just...bigger than normal. A really large raccoon falls out of a tree and dents a car, a remarkably large bird flies off with a baby's sweater, that sort of thing. They don't wreak havoc so much as a low level of annoyance.
One Calvin and Hobbes strip has Calvin imagining drinking a magic elixir, growing to over 300 feet and rampaging through a town. The town was only a model built in his sandbox, but his mom is not amused when he asks for replacements for the toy cars that were crushed in his rampage.
One story arc had Calvin imagining he grows so large that he outgrows the earth.
A number of TheFarSide strips feature giant monsters, including one skyscraper-sized mailman and a group of dogs rallying to save the city.
Happens in Opole rather regularly. Most cases are caused by Doctor Wyspa who, being an avid wargamer, loves humongous killer robots; Godzilla also happened to visit the city at least once.
Recurring villain Zoster of Paperinik New Adventures in his last appearence stole Xadhoom's powers and use them to become as big as the SUN. How many foot are those? fortunately it was all a plan of Xadhoom that she created before dying. In fact it was the last appearence of Zoster because the experiment killed him.
Meriem runs afoul of a nest of giant spiders in Cavewoman: Deadly Venom.
the Help Me! Dr.Hazama fanfic known as Disaster Piece Theatre has Professor Kokenoe grow to gigantic sizes after her rage consumes her. She is brought down after Ragna shrinks her with an antidote. It was, indeed, a strange day.
In With Strings Attached, the four are at one point shrunk to six inches high. George transforms himself to normal height (unfortunately, his clothing doesn't, no Magic Pants for him), which makes him seem like he's grown to about 400 feet high in relation to the others. Whether he can really grow that tall remains to be seen.
One Harry Potter fanfic set in a reality where a wizard's "coming of age" had a tiny chance of changing them into a magical creature featured Hermione turning into a giantess. Needless to say, sexual frustration abounded.
In Fantasy Of Utter Ridiculousness, a group of fairies are transformed into giants by some wind-borne magic powder. It doesn't increase their threat level all that much, however; they still get thrashed just as easily by the story's protagonists as they would by Reimu or Marisa.
Fluttersized is all about Fluttershy becoming huge after a misfired spell by Twilight. There's even an Alternate Continuity where she gets "Discorded" into a mean persona and starts rampgaing through Canterlot, Godzilla-style. She even fights a giant Rainbow Dash!
Attack of the 50-Ft Half-Klingon, a Star Trek: Voyager fanfic by Odon, has an oversized B'Elanna Torres appearing in the Captain Proton holodeck program to wreck revenge on her philandering husband.
The story Rainbow Dash: The Big Battle from the MLP:FiM fanfic collection The Monster Mash features both a giant salamander and a giant Rainbow Dash.
A giant Discord razes Ponyville for much of the Pony Dot Mov series. In SWAG.MOV, Rainbow Dash grows to an equal height to battle him.
Attack of the 50-Bit Nicelanderis what happens you combine Nicelander Gene with malfunctioning power-ups from Sugar Rush. Things are funny up until the point everyone learns that the game can not handle Gene's added bit-space and might malfunction because of it. With many non-Fix-it-Felix Jr. characters blaming him for the inevitable crash, Gene actually goes on a rampage in Niceland after suffering a breakdown and nearly takes our Felix and Ralph in the process.
The Amazing Colossal Man (mentioned above) might just as well be called Attack of the 60-Foot Man, and it came out in 1957, the year before the trope-namer.
An entertaining example comes from the climax of Ghostbusters, when Big Bad Gozer makes the Busters choose a form for the monster it will summon to destroy New York City. While the other Ghostbusters try to empty their minds, Ray tries to think of the most harmless thing he can imagine: the mascot for Stay-Puft Marshmallows. Which results in a giant, grinning, sailor-hat wearing humanoid monster made of marshmallows stomping through Manhattan.
In Honey, I Blew Up The Kid, Wayne Szalinski's 2-year-old son Adam gets hit with a growth ray. The more electrical appliances that the little guy gets exposed to, the bigger he gets. Near the end of the movie, Adam goes to Las Vegas and gets even bigger, and at one point, two Japanese tourists briefly appear:
Female Japanese tourist: Gojira!
Male Japanese tourist: No!... Big baby!
The classic sci-fi film Village of the Giants, from the aforementioned Bert I Gordon, features a gang of delinquent teenagers becoming giants. They then take over the small town ... and dance a lot. (Interestingly, does not feature Magic Pants for the growing characters.)
The little-remembered Japanese monster movie from the makers of Godzilla, Frankenstein Conquers The World, featured a child who survives the atomic bombing of Hiroshima, finds and eats the irradiated heart of Frankenstein's monster, and turns into a giant wild-man who fights a giant lizard-beast. Whew.
It is, however, inspired by the Australian satire The Year of the Angry Rabbit by Russell Braddon. In that novel though the (ordinary-sized) rabbits are infected with a highly-toxic (to humans) strain of myxomatosis.
In Monsters vs. Aliens, the leading woman is turned into a 50 foot (well, 49-foot, 11 and 1/2-inch) woman by being doused with Quantonium. Naturally...
It's worth mentioning that while most of the tomatoes in Attack of the Killer Tomatoes! were smaller than people, they were very large for tomatoes. (One human-stomper-sized tomato did appear at the climax.) It's worth mentioning so I can bring up this line:
Scientist examining giant tomato: "Gentlemen, it's worse than we thought. This, God help us, is a cherry tomato."
In the classic '50s monster movie Them!, the US Army learns what's worse than a single giant radioactive ant: A hive of them. This movie came out in 1954, before giant monsters were commonly used in movies. The first half of this movie is played like a detective story, then you get a Genre Shift.
Mega Shark Vs Giant Octopus, dear god. Z grade disaster flick where a Mega Shark and a Giant Octopus get unfrozen by Global Warming, with scenes of the Octopus sinking an offshore oil refinery, the Mega Shark biting a section out of the Golden Gate Bridge, and best of all, the Mega Shark jumping god knows how far into the air to bite a 747 in half.
Alligator featured a pet baby alligator flushed down a sewer where it grows to massive dimensions eating test animals illegally dumped by a chemical company. Well-done comic horror, and written by John Sayles, yet.
You must acknowledge CROKER!!! or he will eat your head!
In Shorts, Stacey is holding the wishing rock when she wishes her boyfriend would grow up. Guess what happens.
A Shout-Out in Planet 51 as there's a manual about how to handle yourself when a giant woman attacks with a picture similar to the poster above on its cover.
The main characters in Shrek 2 bake a giant gingerbread man named Mongo to lay siege to the castle.
And in the Shrek prequel Puss in Boots the Mother of All Gooses (well, one Golden Goose) rampages through a Spanish town.
A heroic example turns up in the climax of The Muppet Movie. Doc Hopper has just ordered his hired goons to kill Kermit the Frog and company, and as they prepare to do so a rumbling is heard...a previous scene had set up that Dr. Bunsen Honeydew had created "Insta-Grow Pills" that have "sadly, temporary" effects. It turns out that Animal has taken some of them, and when he bursts out of one of the buildings and roars, the villains flee and the good guys cheer.
In Pacific Rim, after Kaiju emerge from the Pacific hellbent on destroying humanity, giant robots are built to combat them.
Happens in the first chapter of Gullivers Travels.To the Lilliputians, the protagonist is the fifty-foot whatever.
Alice in Wonderland, wherein it is Portal cakes, tonics, and pieces of mushroom that cause Alice's vast changes in size - though these changes are irregular: when Alice first expands in the White Rabbit's house, she appears to be as normally proportioned as ever, but when she eats part of the Caterpillar's mushroom, her neck is described as having grown serpentine and winding compared to the rest of her.
An early David Sedaris essay talks about trying to write erotica for a Giantess fetish magazine. He harbors no such fetish himself, he simply needs any job he can get. He ponders the more mundane aspects of being a giant that tends to get glossed over in such works. (How would they find enough food to eat? Wouldn't it be lonely? Wouldn't a bowel movement evacuate a city?)
At the end of Unseen Academicals, reports arrive of a seventy-foot monster chicken rampaging through Pseudopolis.
An interesting inversion of the "army battles giant monster" is the Stephen King short story "Battleground", where a hitman finds himself battling toy soldiers that have come to life. This is specially brought across in the short film adaptation, where we often see things from the POV of the toys.
Funnelweb by Richard Ryan has giant mutant funnelweb spiders rampaging across Australia.
The Food of the Gods and How It Came to Earth, by H. G. Wells, is about a substance called Herakleophorbia IV that causes whatever consumes it to continue growing throughout its life cycle. Soon giant insects, animals, and plants abound, causing no end of trouble for the remaining normal-sized population. The novella ends on the eve of a war between the "Children of the Food" and the "Pygmies."
In the TSR Endless Quest book Revenge of the Rainbow Dragons, if you chose to drink this unknown potion that said it'd make you "strong," then you got an ending where the main character turned into a giant.
On page 73 of the Canadian grade 9 French textbook Sans Frontieres we see a movie poster for Zagora. The monster is just a Horned Lizard with wings badly photoshopped onto in.
The Tubes has a song titled "Attack of the 50 Foot Woman", a tribute of the movie of the same name.
"Attack of the 60 Foot Lesbian Octopus" by Does it Offend You, Yeah?
When a king tries to take her for his queen and take her away from her father and creator, the title Robot Girl of the Voltaire song "The Mechanical Girl" proceeds to grow to seven times her size before putting her flamethrowers and rocket launchers to work in destroying his kingdom.
Space's fifth album, Attack Of The Mutant 50-Foot Kebab.
The "Weird Al" Yankovic song Attack of the Radioactive Hamsters from a Planet Near Mars is about this, with the titular hamsters growing to gigantic proportions.
The music video for "Miserable" by Lit has the band playing on a giant Pamela Anderson. She eats them.
The music video for "Love Machine" by Morning Musume does this to Mari Yaguchi, who happened to be the shortest member of the group at the time. The video for "Kare to Issho ni Omise ga Shitai" also had this with Risa Niigaki fighting a Godzilla expy, apparently with The Power of Love.
Ayumi Hamasaki's video Sexy Little Things include a gigantic woman bursting through a wall, her head almost as tall as the wall itself.
The video for the Beastie BoysIntergalactic features a giant robot (piloted by three scientists played by the group members) battling a giant sea creature in Tokyo in a parody of kaiju films.
"Giving You Up" by Kylie Minogue has a giant Kylie walking the streets and flirting in a club with a somewhat dorky dude, though she looks only around twelve feet tall.
The 3rd Edition of Dungeons & Dragons has a supplement called the Epic Level Handbook. Aside from monsters that are tremendously powerful, a disproportionate number of the monsters are also tremendously big, such as the Flesh, Stone, and Iron Colossi (super-sized versions of the more common flesh, stone, and iron golems) and the devastation vermin (really big bugs). In Monster Manual II, there is also a template to take a tiny or smaller creature and make it bigger than a house.
In the older Spelljammer setting, there were Giant Space Hamsters — roughly the size of bears — bred from regular hamsters by Krynnish Tinker Gnomes. And then they bred some of them back to regular hamster size, creating Miniature Giant Space Hamsters, because Tinker Gnomes are weird. Famously, Boo of Baldur's Gate may or may not actually be a Miniature Giant Space Hamster.
And then we get into the really out there variations, like the Sabertooth Giant Space Hamster or the Flying Carnivorous Giant Space Hamster.
And the Firebreathing Phase Doppleganger Giant Space Hamster.
Magic: The Gathering has Giant Growth, one of the most commonly reprinted cards of the game. The world of Naya from Shards of Alara is home to enormous creatures known as "gargantuans", which are worshiped by the local elves and humans.
Warhammer 40,000 seems to have a fondness for using "battle tank" as a standard size for wildlife, and Tyranids revel in this trope with their heavier creatures, especially the Bio-Titans.
Warhammer Fantasy is currently going into this trend as well, giving each of the factions new big monsters. The crowning one was the Arachnork Spider, which was so large it's base dwarfs the Land Raider, the second largest tank in 40k, who was then followed by the Zombie Dragon and the horrifying batlike Terrorghast, which shares a base with it. Storm of Magic turned it Up to Eleven with a whole slew of new monsters and beasts that any wizard can call upon to fight for him/her.
One of the Kiths available to Ogre characters in Changeling: The Lost gives you this as its special power. Depending on how powerful you are and how big you are already, you grow to anything from the size of a gorilla to bigger than an SUV. Coincidentally, this Kith is called the Gargantuan.
Exalted has some of its behemoths, and any Lunar with Emperor Ox Expansion. One character, Leviathan, has spent the past two millennia as an orca roughly the size of a small island.
Many of the Shintai charms, native to the Green Sun Princes, turns its user into a 50-feet version of their patrons, themselves are hundreds of feetscary things. For example, you can turn into massive humanoid sandstorm, massive tentacular sea monster, massive green radioactive star... And if you go Devil-Tiger route, you can have Attack of the 50 Feet You.
Gammarauders has the bioborgs, giant cyborg creatures that can be fitted with various weapons. There are also conventional forces (in the form of aircraft, tanks, and infantry), which are collectively referred to by players (and the official manual) as popcorn. They can make a difference in a battle between bioborgs ... but not much of one.
A new musical version of Creature from the Black Lagoon at Universal Studios Hollywood features an enormous puppet of the Gillman at the end, made his unnatural size by an accidental application of... ahem... male anatomy enhancers.
In The Simpsons Ride, also at Universal Studios, Maggie wanders into a nuclear reactor and later appears as a giant, serving as something of a Deus ex Machina.
BIONICLE Rahi Nui is already about 50 feet tall in its standard form (and it also attacks). But it has the power to grow even larger. So large, in fact, that this has once caused its molecules to split, since it couldn't control its density.
Late in the Japan-only PC-FX game Makeruna! Makendou Z, after our heroes are put to sleep by Honmayaner, Hikari dreams that she is a giantess fighting a three-headed dragon.
At the end of Sonic Adventure, after Dr. Eggman feeds it all seven Chaos Emeralds, Chaos becomes a 50-foot sea serpent that rises from a flood in Station Square.
Perfect Chaos doesn't just rise from the flood; it is the flood!
An important part of the story in Super Mario RPG involves a giant sword that destroyed the Star Road and crashed right into Bowser's Keep.
Knuckles Chaotix has Metal Sonic being transformed into a 50-foot monstrosity after being defeated the first time.
Throughout the game, there are also power-ups that either double or half a character's size, and allows that character more or less control respectively over his partner.
Zombies Ate My Neighbors features such bosses as giant babies, giant snakes, and two mad scientists who turn into giant red tarantulas.
The level with the giant ants. It's not a boss, but a level where the enemies are giant ants.
Almost every single boss in the Contra series is a 50-foot robot or alien.
One scenario in Osu! Tatakae! Ouendan revolves around a Salaryman growing to gigantic height to fight a giant blue mouse that was attacking the city. The second Ouendan game had a giant cat called Nyaragon.
Said Nyaragon was based on the monster from a movie that was being made in Elite Beat Agents, Ouendan's sister series.
In Super Mario World 2: Yoshi's Island, the bosses are normal enemies made giant by the magic of Kamek (except for one battle that involved Yoshi and Baby Mario getting shrunk). In fact the final battle involved Kamek enlarging Baby Bowser to a size bigger than the castle they were in.
Mario & Luigi: Bowser's Inside Story has Bowser being super-charged on adrenaline and growing super giant in order to battle his hijacked castle, a giant robot coming out of nowhere, a train, and Princess Peach's Castle (as remodeled by Fawful), preceded by Bowser being crushed by said buildings.
Mario & Luigi: Dream Team has Luigi grow to giant size in the Dream World to face off against giant bosses. In a nod to the previous game, he ultimately gets to face off against a giant Bowser in what's probably his most triumphant moment in the series.
Come to think of it, wouldn't the Mario Brothers themselves be a small version of this? Give 'em a mushroom and they double in height.
In the Japanese PS2 game The Daibijin, the player must pilot a helicopter, and in one stage an airplane, against a bikini-clad woman who had been brainwashed and turned into a giant by aliens. Seriously.
In Majora's Mask, the boss of Stone Tower Temple is a set of [masked] humongous desert worms that fly. The simplest way to fight them is to don the Giant's Mask, which will grow you to similar size to give you a fighting chance. (Or you could don the Fierce Deity Mask and get a laser-beam shooting sword, or just use your bow if you're out of mana and don't have the latter mask.)
In Skyward Sword features the Imprisoned, a giant Armless Biped that you must stop from walking up a spiral path and into a temple. The most basic method of killing it isn't Colossus Climbing it, but rather attacking its feet to bring its weak spot down to you.
In Shadow of the Colossus, there are several 50-foot whatever. Sixteen actually. And you attack them!. The two smallest ones are about the size of an elephant.
In Super Smash Bros. Brawl, Jigglypuff's Final Smash, Puff Up, causes her to grow/inflate to such a size that it can push other characters off the stage. Most evident on small stages.
Bowser's equivalent Final Smash move involves turning into the dreaded Giga Bowser and wreaking havoc on everybody. Giga Bowser is much larger in Melee than he is in Brawl, and can get Super-Mushroomed to a downright ridiculous size.
One stage of Parappa The Rapper 2 involves Parappa and an ant being repeatedly shrunk and then grown to enormous size.
The arcade rail shooter Lets Go Jungle! features hordes of giant critters as enemies. In addition to giant spiders, there's giant wasps, giant frogs, a giant mantis, and the final boss is a giant killer butterfly.
City of Heroes has the 'Giant Monster' enemy class for foes that fall under this trope. Most of them spawn in open areas and are specially coded so that characters of any level can deal substantial damage to them. Some like the Kraken, Eochai and Devouring Earth monsters are simply giant versions of regular mooks, but there's also Lusca the gigantic octopus, Jack In Irons the giant... well, the giant, and one of the ultimate Big Bads of the game; Hamidon- a colossal single-celled organism that takes dozens of players and special tactics to defeat.
Adamastor the giant zombie, and the Humongous Mecha piloted by U'kon'Grai, Rikti Master at Arms with a name that's one big in-joke.
Spore gives us Epic creatures, larger versions of creatures made by other players that start off at a large, but not ridiculously so size in the creature stage, but become downright massive in Civilization. In Space phase, you can use the "Supersizer" tool to enlarge creatures, turning the scenario into "Attack Of The 50 Foot Whatever You Want". Furry Confusion ensues when the game selects a species whose hnau version you brought up to Diplomat Hero in the last game.
Every single major world boss in the Bubble Bobble series: huge compared to the protagonists.
Kraid in Super Metroid and Metroid: Zero Mission. He stands about two map squares tall and naturally towers over Samus. In both games, Kraid is the first major boss fight, and is shockingly weak in health, despite his size. He attacks by shooting his belly spikes and flinging his detachable claws at Samus.
Quadraxis from Metroid Prime 2 is downright HUGE; his head alone is a little bigger than Samus' gunship!
Prime 2 also has Chykka, Emperor Ing, and Amorbis
Then from Prime you have Thardus, Metroid Prime, Flaaghra, and the Omega Pirate.
Prime 3 has Mogenar, and AU 313. Safe to say that Metroid loves this trope.
Bentley: You've always wanted to get closer to her. Can't get much closer than climbing up her boot laces!
The Matrix The Path Of Neo at the end of the game, which corresponds with the end of Matrix Revolutions, two avatars of the Wachowski brothers themselves speak directly to the player and explain that, while the Martyr ending was OK for the movies and the story, it just wouldn't work that well for a videogame. So instead, all the Smiths get together and grab various bits of destroyed junk and debris, as well as a giant pair or sunglasses from an ad, and for a GIANT Smith.
Unintentionally subverted in Age of Mythology, as the Giants, Frost Giants, Fire Giants and Greek colossuses are only about two or three (four tops) times the size of the human figures.
Then you buy the expansion pack and watch and marvel as your enemies get goomba stomped by a giant birdman which took you an hour or so to build.
Kirby 64: The Crystal Shards downplays this. Rock + Rock turns Kirby into an oversized Mighty Glacier version of himself. Take Fridge Logic and the fact that Kirby's 8" tall, and you realize that the Rock + Rock Kirby is 1'04"! (50ft would actually be 37.5 times as large as Rock + Rock Kirby)
An early level in 3D Lemmings is "Attack of the 50 foot Lemming" — your lemmings start on the giant lemming's head and make their way down to the feet. Unfortunately there's no attacking, just a level designed to look like a giant lemming.
World of Warcraft has a few monstrous foes. Vanilla has the Devilsaurs, various giants, and the Fire Lord Ragnaros. The Burning Crusade added Fel Reavers, Colossi (crystalline giants), and the one-eyed Gronn. Cataclysm is bringing in Whale Sharks and Neltharion himself, who is FREAKING HUGE!
In Wrath Of The Lich King, the Ulduar raid dungeon is a Titan city, and thus is made of this trope, by this trope, for this trope.
You also get to be this in one of the new dungeons (Throne of the Tides) for part of the last boss, where you have to drive away a gigantic squid from the equivalent of a water god's lair.
Suika utilizes her control of density to grow herself really large and heavy for some of her attacks in Immaterial and Missing Power and Scarlet Weather Rhapsody.
The plot of Hisoutensoku boils down to three characters seeing an impossibly huge shadow of something and going off in pursuit of whatever it was (though only one of them successfully tracks down the cause of their respective shadow). The last boss fights of Cirno's and Meiling's scenarios do this to a doll and a catfish, respectively. In the latter case, the catfish starts off as merely huge and continues to grow each time it attacks. Sanae's scenario inverts this by making her last boss the shortest character in the game.
Asura's Wrath takes this to a RIDICULOUS level, as the final form of the first boss turns to the size of a planet and tries to CRUSH YOU TO DEATH WITH A FINGER THE SIZE OF TENNESSEE!
Probably the ultimate example of this in both Asura's Wrath and possibly all of gaming is Chakravartin, who's extension of his power is so big his basic projectiles are Planets and Small Stars, he throws suns at you later, and Galaxies are small in comparison to him. He's really , REALLY big.
EarthBound has one area, the Lost Underworld, where everything is so huge that the characters' sprites shrink. This includes the enemies.
Lordran in Dark Souls is littered with dangerous giant beasts, such as wolves, armored boars, and magic-shooting butterflies.
On the Rain-Slick Precipice of Darkness starts with Penny Arcade's Gabe and Tycho chasing after this giant robot that flattened your character's house.
Monster Hunter is all about tackling large monsters that can easily fling you around like a ragdoll without proper preparation (as in being Crazy-Prepared). Amongst the largest of the lot are Elder Dragons Lao Shan-Lung, which is a red Godzilla; Jhen Mohran, a sand-swimming cross between a crocodile and a living mountain, whose spine can be mined for rare ore; Ceadeus, a whale-like aquatic monstrosity; and topping the list is Raviente, a colossal tusked serpent as big as an island.
The final boss of Serious Sam: the First Encounter is Ugh Zan III, a giant four armed monster who is so big that Serious Sam only reaches up to his foot. Almost all of the second-to-last level is about outrunning him to the super weapon stored inside a pyramid because he's too damn big. He's an actual enemy inside the level, not just an Advancing Wall of Doom (though he functions the same way).
One of the movie scripts in Pokémon Black and White Version 2 is this; the protagonist's girlfriend/sister is turned into a giant in the middle of the city by a cursed pokeball, and much panic and flailing ensues.
Fallout 3 has Super Mutant Behemoths, and on the player's side, Liberty Prime.
Lemegeton's first episode ends with a fight against Gaap, a huge demon who may literally be fifty feet tall. The best way to describe him is a kind of humanoid fort that periodically sweeps one side of the room with a petrifying beam.
Attack of the Mutant Camels. To quote from the manual:
The evil alien nasties have invaded the earth - but not in person! They have abducted some camels from earth and used devious genetic engineering to mutate the normally harmless beasts into 90 foot high, laser spitting, neutronium shielded death camels!
And as the incredible art above this paragraph illustrates, (the Mecha-Engineer) will be over one hundred feet tall! (It will not.) Not to worry, though, because it looks like Engineer will also be one hundred feet tall! (He also will not.)
In the Sluggy Freelance arc "GOFOTRON, Champion of the Cosmos", the titular Combining Mecha regularly battles giant monsters created by the evil Zorgon empire. One of these creatures was a hundred-foot broccoli monster.
Due to the sexual fetish for giant creatures known as macrophilia, there are plenty of sites and sections of sites dedicated to drawings, comics, stories, "poser" animations and live action videos about women, men, Kaiju, animals and furry characters growing to giant size. So, uh...happy hunting.
Shapeshifter Jimmy T in the Whateley Universe did this when all of Whateley Academy was under attack. He first transformed into a 50 foot woman, and when he got blasted, he went bigger. He shifted into an 80-foot Godzilla copy.
In the Johnny Bravo cartoon "Jumbo Johnny", an overdose of protein shakes made Johnny fat, and enough of them eventually made him grow to a gigantic height.
Kim Possible, "Rufus vs. Commodore Puddles". Fifty-foot naked mole-rat against equally large French poodle, in combat at Area 51. The garrison there kept giant, truck-mounted dog whistles and bombers full of dog biscuits available for just that situation. "Full frontal assault by giant canine. That's a forty-one stroke five-S scenario."
Futurama spoofed this in its What If? episode, with Bender coming to earth as a 500-foot version of his regular self, and Dr. Zoidberg being supersized to battle him. (The spoof aspect comes when Zoidberg is seduced by power and begins destroying the city himself - "The Apollo theater! Boo me off the stage on Open Mike night, will you?!?")
This trope was also played straight in the episode Benderama, wherein a 50-foot nerd attacks New New York City.
Sheep in the Big City spoofed this with their "commercial" segments in between the story pieces. This sentence says it all: "Attack of the 50 Foot Creature", in other words, a monster made of 50 human feet (known in Europe as "The Approximately 17 Meter Tall Creature That Happens To Be Made Entirely Of Feet Movie")
Happens to Jade in Jackie Chan Adventures as she tries to cast a spell to become older and instead becomes huge. Her destruction, however, is limited to a demolition zone as she battled a giant ogre conjured by the Big Bad. Also see Po Kong the Mountain Demon, who is Exactly What It Says on the Tin. Tohru, in reference to this, becomes one briefly too.
As usual, Tex Avery played this trope to the hilt in King Size Canary, in which a bird, cat, dog, and mouse enlarge themselves by drinking Jumbo-Gro plant food. The cartoon ends with the cat and mouse standing over a basketball-sized Earth.
The Tick vs. Dinosaur Neil, in which a paleontologist in a dinosaur costume turns into the real thing after mistaking prehistoric genetic material for pasta salad.
A later episode had the series' Big Bad Chairface Chippendale using a pill to turn Neil back into a dinosaur on his wedding night.
In The Powerpuff Girls, the girls frequently fight giant monsters, often from a place called Monster Island (although they are allies with at least one of them, who in one episode helps them expose the fraudulent hero Major Man).
Used as part of a plan by Mojo Jojo. He made the girls grow, not himself.
Sedusa also turns huge in one episode.
The fish balloon that destroys Tokyo Townsville.
Him has shown this power several times.
Parodied in one episode of The New Adventures of Winnie the Pooh. Piglet is depressed about being so small, so the others make him think he has grown by tying boxes on his feet and putting binoculars backwards in front of his eyes. In another episode, Tigger tells a scary story where a giant Pooh scours the land for honey.
Ultra-Pipi from the Invader Zim episode "Hamstergeddon". He even gets back ridge-plates and atomic breath after demolishing a nuclear power plant. And somehow a cybernetic foot. (Because it looks cool, I guess)
Also from Justice League Unlimited, Supergirl once fought a giant fire-breathing turtle creature in Japan. (Its shock of red hair and the way it shrunk when defeated means it might have been a Shout-Out to Jimmy Olsen's Silver Age stint as "Giant Turtle Boy" as well as Bowser and/or Gamera.)
Also from Super Friends is the episode "The Giants of Doom". Guess what happens to Bizarro, Sinestro, Captain Cold, and Toyman in that one.
The Simpsons had Homer turn into a gigantic, carnivorous blob as part of one Halloween episode. In the same episode, we see a 50-foot Lenny bemoaning that everyone's paying attention to Homer - except for Invisible Carl.
Before that it was done in a Treehouse Of Horror comic titled Sideshow Blob; Sideshow Bob become a rampaging blob monster after being injected with a serum.
And their other Halloween ep, Attack of the 50 Foot Eyesores, with local advertising icons run amuck.
In "Fake Me to Your Leader", Professor Nimnul fakes an alien invasion by enlarging insects to around twice the size of a human. Little does he know until near the end of the episode that he also accidentally zapped Zipper with his Gigantico Gun, resulting in the smallest Rescue Ranger becoming a giant who ends up stopping him. The other Rangers manage to get the gun, set it to reverse, and shrink Zipper back to his normal size.
Also used for a couple of brief scenes in "Puffed Rangers". The villains unwittingly enlarge the Rangers, who then end up scaring them off. Monty gets to have a bit of fun before returning to normal size.
Men in Black: The Series had the humans enormous compared to a race of tiny aliens trying some nefarious plot to become large. One alien actually did, but became a 50-foot whatever; requiring the MIB to deploy their own 50-foot whatever as well.
In the two-part episode "Pan-demic", the world is under attack by giant guinea pigs. Giant live-action guinea pigs. They are joined by guinea bees, guinea rats, and other guinea creatures (which are just guinea pigs in costumes).
And Trapper-Keeper Cartman.
And most recently Cthulhu.
Played for laughs with Scott the Dick in "Royal Pudding." At first, it appears to be played straight, but a change in the camera angle reveals that he's actually seven feet tall.
Subverted in Buzz Lightyear of Star Command with giant extremists of the planet (ironically named) Gargantua. The subversion comes through the fact that the natural height of a Gargantuan is six inches and the 6 foot terrorists are actually turning off the tech that the heroes are using to avoid this problem in their natural height (earlier, Booster was a little upset that his seat for a ceremony was a bank).
Seen in one The Batman episode where the nanobot enhanced Joker 2.0 learns to increase his size by changing objects into nanobots, becoming a giant and decides to destroy both the original Joker and the heroes, leaving the city free for him to ravage.
Duckman ate a combination of odd chemicals that caused him to grow whenever he got angry. Duckman being Duckman, by the end he was taller than a two-story house, and went to a deserted island so his anger wouldn't hurt himself or anyone else. While he was isolated, his depression shrank him to mouse size, but he had no frame of reference, so he couldn't tell.
Oberon in Gargoyles makes himself gigantic when trying to kidnap Alexander Xanatos.
There was an episode of Wow! Wow! Wubbzy! called "Attack of the 50-Foot Fleegle," featuring an animal called a fleegle that would grow in size when given candy.
In the Sushi Pack episode, "A Very Big Deal," Ikura is shot by a malfunctioning shrink ray and grows to enormous size, fulfilling his earlier wish to be bigger.
On Phineas and Ferb, Candace uses a growth potion the boys made in order to grow an extra two inches; it makes her gigantic instead. The episode was aptly called "Attack of the 50-Foot Sister".
Darkwing Duck spends the end of "Planet of the Capes" this way. So did the villain, until the ray they were using to grow was broken. When you start using astronomical phenomena as melee and thrown weapons, you've put on a little weight.
Waybig, from Ben 10: Alien Force is a good guy example. He's even called a Toku'star, after the tokusatsu genre. One episode had a Taking You with Me failsafe that created a giant monster designed to nuke the earth. It was activated by a Highbreed officer who didn't get the memo.
And now in Ben 10: Ultimate Alien Gwen has had her moment too, growing very large to intimidate Zombozo the second time she takes her Anodite form.
Davey Hacker uses a gadget to make himself gigantic in The Amazing Spiez episode "Operation The 50 Ft. Hacker." Megan winds up using the same gadget to make herself giant as well, but it eventually backfires and causes her to expand like a balloon.
There was also the Totally Spies! episode "Attack of the 50 Ft. Mandy".
There are several Sponge Bob Square Pants episodes which feature this trope. In one episode Squidward becomes a giant after getting sprayed with plant fertilizer, and in another episode SpongeBob inadvertently becomes a giant after shrinking everybody in Bikini Bottom.
Eileen from WordGirl increases in size if she does not get what she wants, and she even grew taller than a skyscraper in the episode "The Birthday Girl".
In the episode "The Faery Princess" of Princess Gwenevere and the Jewel Riders, the evil sorceress Lale Kale arrives in the land of little fairies and decided it's a perfect new kingdom of her to rule, so she seizes its king and to attempts to proclaim herself the new queen (however fails miserably).
In the Pinky and the Brain episode "Tokyo Grows" Brain enlarges Pinky and himself so that Pinky can disguise himself as Gollyzilla (a parody of Godzilla) and Brain would defeat him in combat so he can be deemed a hero; things don't go as planned when the real Gollyzilla shows up.
Spoofed on Robot Chicken with "Attack of the Giant Midget!" The 'midget' in question is about 6'5" or so, and his 'attack' consists of doing regular tall guy stuff like riding a roller coaster, getting the cookie jar on top of the fridge, and playing basketball.
Happened once in Trollz. Dragon vs. Fifty-Foot Kitty.
In The New Adventures of Superman episode "The Chimp Who Made It Big", the chimpanzee Toto mutates into the giant ape Titano after being exposed to the radiation released in a collision between a kryptonite meteor and a uranium asteroid.
He's also turned giant in the Sparkle World magazine story The Hero of Ponyville!, in this case due to having brushed against a magic plant. As a giant baby dragon, he retains his usual appearance (read: the illustrations use resized stock art of regular Spike).
In another episode, Rocko wishes he were bigger, then dreams that he's become so big he bumps his head on the sun.
In Muppet Babies, the gang are pretending to have a magic lamp and take turns making wishes. Gonzo wishes he had a "great, big kiss from Piggy", but what he gets is a kiss from a great, big Piggy.
In an earlier episode, Piggy is a giant dough monster attacking a city. Bunsen tries to stop her with his Beast Blaster, but Beaker gives him a yeast blaster by mistake, which makes her bigger still. They make Gonzo bigger to stop her, but the two just end up falling in love.
Now granted, your average Cybertronian is generally around 20ft tall to begin with, but some of the larger 'bots like Metroplex and Fortress Maximus made them look tiny by comparison. Taken Up to Eleven with Primus and Unicron, who transform into planets.
From The Legend of Korra, after fusing with Vaatu to become a Dark Avatar, Unalaq grows to gigantic size, goes to Republic City, and starts wreaking havoc. Korra does the same thing, but she does this to fight against her corrupt uncle in a massive final showdown.
The Rainbow Magic movie has a giant snowman attack Rachel and Kirsty.