- The villain suffers from a mental breakdown.
- The villain immediately becomes evil again and turns against the heroes.
- The villain realizes the damage he had done and decides to pull a genuine Heel–Face Turn to redeem himself.
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Anime & Manga
- Light Yagami of Death Note does this as part of his Memory Gambit, having given up his memories of being Kira and joining the Kira taskforce, even working together with his nemesis L. Light without the Death Note is actually a pretty decent guy, but we know that this cannot last, and sure enough, after a very convoluted Gambit Roulette, Light reclaims the Death Note and regains his memories and everything goes to hell.
Film — Animated
- At the end of Kubo and the Two Strings, after the Moon King/Raiden is brought down into human form, he loses all memory of who he is or any of the things he's done, despite having tried to kill Kubo only minutes earlier. Despite this, Kubo and the townspeople decide to respect Raiden and tell him that he was a great person. He is very happy to hear this and decides to devote himself to "continuing" his generous lifestyle.
- This is part of The Reveal in Knights of the Old Republic: the player character is actually Darth Revan, who had his/her mind wiped by the Jedi Council to ensure that (s)he would no longer be a threat to the galaxy. Following this, the player can decide whether to remain heroic or else take over as the new Dark Lord of the Sith.
- Mortal Kombat: Before the events of Mortal Kombat 3. Kabal was a member of Black Dragon who was victim of Shao Kahn's extermination forces and left for dead. He was disfigured, the reason why he has to use a gas mask permanently, and with his memories gone joining to Earthrealm forces against Shao Kahn. He eventually regained his memories after MK3, as seen in his next appearance in Mortal Kombat: Deception, in which he not just comes back to Black Dragon clan, he also wants to remake the organization from the ashes.
- The twist of the emotional rollercoaster known as MySims SkyHeroes is that the player character used to be the chief enforcer for the evil Morcubus, before getting shot out of the sky and left amnesiac to be unwittingly picked up by the resistance against Morcubus.
- In the Adventures of Sonic the Hedgehog episode, "Blank-Headed Eagle", Scratch chases after Sonic with an Eagle-Copter kit he ordered from watching the Edgar Eagle TV show. After Sonic tricks him into shooting himself out of the sky, Scratch gets amnesia, and when Henrietta Peck finds him, Scratch thinks he's Edgar Eagle. Sonic takes advantage of this and uses Scratch to help him save Farmer Peck's farm from destruction from Dr. Robotnik's machines. Scratch ends up regaining his memories near the end of the episode.
- Class of the Titans: After Big Bad Cronus and all the team fall into the River Lethe and lose their memories, Cronus becomes totally amicable and joins the gang in trying to work out what's going on.
- Xiaolin Showdown: The Season 2 finale has Jack Spicer accidentally turn himself good when he brought the Reversing Mirror into the Yin Yang World, reversing his own spirit in the process. He remains with the heroes until needing to enter the Yin Yang World again, resetting his spirit back to evil (but not before creating a good clone of himself in the meantime.)
- In the Skylanders Academy episode "Sheep(ball) Dreams", the Skylanders attempt to have an amnesiac Dreamcatcher leave the Doom Raiders and rejoin them.