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- Captain Carrot and His Amazing Zoo Crew! took place on an alternate Earth (Earth-C), which Superman crossed over into once. They have their own alternate too, Earth C-Minus, where the events that Rodney Rabbit writes in comic books take place for real.
- Ghostbusters (IDW) establishes that there are two Ghostbusters universes: One in which Ghostbusters (1984), Ghostbusters II, the 2009 video game, and the IDW series take place, and one in which the animated series The Real Ghostbusters and Extreme Ghostbusters take place, and the films are fictional. While there are some callbacks and references between the two (mostly in the form of background gags, although Janine's appearance in the comics is a hybrid between her cartoon and film appearances, and an alternate version of Kylie from Extreme Ghostbusters was part of the New Ghostbusters team), they remained mostly separate... until 2015, when IDW did a limited-miniseries crossover between both 'verses.
- Howard the Duck comes from an anthropomorphic-animal universe, albeit without actual cartoon physics.
- Garfield Gets Real, where both the "real world" and Garfield's world are CG animated.
- Cool World: an alternate universe exists, populated by toons (or Doodles as they were called; the humans were called Noids).
- Enchanted, which examines how common Disney Princess tropes would work in the real world. Oddly enough, it wasn't supposed to be a Disney film at first, but became one.
- In Space Jam, the Looney Tunes characters live in an alternate world that can be reached from an underground portal in the center of the Earth.
- In Twilight Zone: The Movie, during "The Good Life" segment, Anthony uses his powers to send his "sister" Ethel into the cartoon world, where she's chased around for a moment before being eaten. In this case, though, Toontown exists because of Anthony's dark powers.
- Invoked in Community, when Abed manages to convince Troy that he's found a doorway to a cartoon world outside Greendale Community College by painting an animated version of himself on a wall:
Troy: That's impossible!
Abed: Nothing's impossible in here! Animals can talk, your heart is shaped like a heart, and the smell of pie can make you float! You have to believe, Troy!
[Troy is just about to run headlong into the wall when:]
Abed: [leaping out from behind a bin] Wait! You don't have to believe.
Troy: [clearly heartbroken] I didn't!... I didn't... [he storms off]
Abed: I may have done some damage there.
- The Fringe episode "Brown Betty" might have featured such an alternate universe, as seen when story-world Nina Sharp communicates with story-world William Bell using the window device (though this may have been a choice to go for a retro-aesthetic).
- Toon Struck: The protagonist, a cartoon animator, ends up in his toon world.
- The webcomic Hexenringe involves at least two dimensions - one like ours and one which is populated by comics characters and other fictional creations.
- Zebra Girl has an alternate universe with cartoon characters whose lives and personalities run parallel with those of the people of the main universe.
- The Aniverse in Bucky O'Hare has anthropomorphs aplenty, but sci-fi physics rather than cartoon ones.
- Timmy of The Fairly OddParents sometimes goes into the comic book world of the Crimson Chin.
- In The Real Ghostbusters episode Who're You Calling Two-Dimensional? the Ghostbusters get trapped in a cartoon world created by the mind of fictional animator Walt Fleishman.