History MadScientist / AnimeAndManga

!!Examples:

* Dr. Hogback from ''Manga/OnePiece'', who builds zombies for his master Gekko Moriah, and has no respect for life despite being a doctor.
** From the Punk Hazard arc, we have Caesar Clown, who's an even bigger asshole, and even more nuts (watch out, loads of spoilers ahead). [[spoiler: He kidnapped and experienced on children, and used a very dangerous drug on them to keep them from escaping, he has absolutely zero respect for anyone, his forte is [[WeaponOfMassDestruction weapons of mass destruction]], he acts like a nice guy to his underlings only to perform more experiments on them later, he caused an incident that made Punk Hazard into a wasteland, then collected the leftover poisonous gas from that incident to make a BlobMonster, which he later changed ''back'' into an even deadlier gas that petrifies its victims]]... What makes it even worse is that [[spoiler: a [[TheMole mole]] in the Marines covers up all of his actions, allowing him to do as he pleases]].

* Dr. Franken von Vogler from the ''Manga/GiantRobo'' OVA was introduced as a classic ranting Mad Scientist. [[spoiler:The series subverts this trope, as successive flashbacks reveal more about his real motivations.]]

* ''Anime/WeissKreuz'' is almost as fond of these as it is of {{Mad Artist}}s -- see particularly Takatori Masafumi, and Tsuji Mayumi in ''Weiss Kreuz: Glühen''.

** TheMovie of [[Anime/FullmetalAlchemist the 2003 anime]] introduces a scientist who is severely ticked at the world's alchemists for making his work worthless. The "mad" part of this shows up when he reveals that he discovered Uranium and threatens the Elrics with a ''hand-held nuke''. Clearly he never tested the thing.

* ''LightNovel/{{Baccano}}'' has Szilard Quates, Huey Laforet, and Renée Brinvillier. All three are immortal alchemists, and also happen to have [[MadScientistsBeautifulDaughter the requisite beautiful daughter]] (with the latter two sharing theirs).

* With ''LightNovel/ACertainMagicalIndex'' being staged in a city technologically ahead of the rest of the world by 30 years, it's no surprise there would be mad scientists. One of the most prominent is an entire clan of mad scientists called the Kiharas, and it's strongly implied in the series that all the experiments they get involved in are solely ''ForScience!'' regardless of implications. To mention just a few:

* Izaya Orihara of ''LightNovel/{{Durarara}}'' is what happens when a mad scientist tries his hand at sociology. Note that this ends up being impossible to distinguish from a {{troll}}.

* ''LightNovel/TheGreatestMagicmastersRetirementPlan'': Godma Barhong is the researcher in charge of Alpha's Element Factor Separation Project. In his experiments to turn test subjects into light magic users, he broke their minds and left most of them as [[FateWorseThanDeath mindless slaves to his will]]. When Alpha's government decided to shut down his research, he went into hiding to continue his experiments, kidnap more test subjects, and kill anyone who tries to stop him.

* Dantalion the [[BossSubtitles Seeking Researcher]] from ''LightNovel/ShakuganNoShana''. He is [[LargeHam outrageously excitable]] and creates his mad experiments ForScience, and not necessarily for evil means. One suspects that if he weren't contracted to the bad guys he'd be mostly harmless. He looks exactly like Father Anderson from ''Manga/{{Hellsing}}''.

** [[SpellMyNameWithAnS Presea]] [[BigBad Testarossa]] from the [[Anime/MagicalGirlLyricalNanoha first season]], who snapped over the [[spoiler:loss of her daughter Alicia, spending decades to find a way to revive her]].
* Another one is [[spoiler:[[ManBehindTheMan Grace O'Connor]]]] from ''Anime/MacrossFrontier''. Though they don’t heavily advertise that they ''are'' a scientist in the first place, in fact [[EvilutionaryBiologist they are]], and not the worst one. Given that [[spoiler:she's also a HotScientist, and what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly badass [[MagnificentBastard Magnificent Bitch]] she comes in the end]], it's simply unfair to leave them out.

* Doc from ''Anime/{{Texhnolyze}}'', who doubles as a HotScientist. Putting aside her prosthetic limb fetish and her tendency to have sex with her patients, she also puts wheels on a rat for no reason other than her own apparent amusement.

* Sucy Manbavaran from ''Anime/LittleWitchAcademia'' is the witching world's equivalent of a mad scientist. She loves coming up with new potions and poisons, then testing them out on unsuspecting victims. [[WithFriendsLikeThese Mostly her friends]]. Sucy's EstablishingCharacterMoment is her trapping Akko and Lotte in a net as bait for a cockatrice so that Sucy can steal one of its feathers as an ingredient for her newest potion.

* In ''Anime/KirbyRightBackAtYa'', one of the many [[MonsterOfTheWeek Monsters of the Week]] is a crazy scientist named Dr. Moro, inspired by ''Literature/TheIslandOfDoctorMoreau'' (no kidding) who messes with the DNA of Kirby, his friends, the Cappies, and of course, [[ThoseTwoBadGuys King Dedede and Escargoon]], and uses them to create dinosaur monsters that chase after them all throughout Dedede's theme park. His most powerful dinosaur monster was created from Kirby's superior Star Warrior DNA, and he turns really freaky when he's ordering his minions to attack. And to top it off, he has the typical EvilLaugh of any other Mad Scientist.

* Nina Einstein from ''Anime/CodeGeass'', a Teenage Mad Scientist Girl. She is particularly known for being a PsychoLesbian and inventing weapons of mass destruction.
** And the [[CargoShip table incident.]] [[NeverLiveItDown And the table incident.]]
** Earl Lloyd Asplund is an older, slightly more comedic version of the trope. His BunnyEarsLawyer status has earned him the FanNickname "Lloyd Aspie".

* Hakase Saotomi and Chao Lingshen from ''Manga/NegimaMagisterNegiMagi'', refer to themselves as having sold their souls to science.

*** However, Lloyd plays it straighter in the AlternateUniverse manga ''Suzaku of the Counterattack'', where he willingly goes along with Prince Schneizel's plan to gain C.C.'s powers in order to ([[Website/ThatGuyWithTheGlasses you guessed it]]) TakeOverTheWorld, even though it could potentially destroy the Earth (and almost does, if not for the intervention of the heroes).

** Dr. Yung, from Mastermind of Mirage Pokémon, who [[spoiler:is revealed to be the titular "mastermind", attempting to take over the world with super-powerful Pokémon holograms]].
** Butler, in the sixth movie, [[spoiler:laughed out of Team Magma for a failed attempt to re-create Groudon]], who now travels as a circus magician, [[spoiler:but tries his experiment again using [[PoweredByAForsakenChild Jirachi as a power source]]]] and ends up having it work a little too well.

* While Shiho Miyano of ''Manga/DetectiveConan'' may not qualify as a Mad Scientist, since she was forced into doing her research, her father Atsushi certainly does. The series specifically mentions that her father was considered a mad scientist even by the standards of the Black Organization. That's pretty mad. [[spoiler: Though Agasa says that Atsushi wasn't ''that'' crazy, but actually a rather decent guy. Since he is Shiho-aka-Ai's ParentalSubstitute, lying about this would be just too risky...]]

* The ''Anime/{{Pokemon}}'' anime loves this trope, especially for villains: