A 1976 medical ConspiracyThriller novel by Robin Cook. In the novel, Susan Wheeler is a medical student working at the Boston Memorial Hospital. Young, healthy patients are coming in for routine operations and leaving in permanent comas. Susan investigates, eventually unearthing an OrganTheft conspiracy.

TheFilmOfTheBook was released in 1978, written and directed by Creator/MichaelCrichton. In the film, Susan is played by Genevieve Bujold and her character is changed from a medical student to a full M.D. The movie also stars Creator/MichaelDouglas as Susan's boyfriend Mark and features a score by Music/JerryGoldsmith.

A MiniSeries version by Creator/RidleyScott and Tony Scott aired on A&E in 2012. Susan, once again portrayed as a medical student, is played by Lauren Ambrose with Steven Pasquale as Mark. Also, the Boston Memorial Hospital is changed to the Peachtree Memorial Hospital, accommodating a change in setting from Boston to Atlanta.

Not to be confused with the Iranian film ''Film/{{Komaa}}''.
!! Provides examples of:

* AmbiguouslyEvil: The movie has some fun making it ambiguous whether Mark genuinely doesn't believe in the conspiracy or if he's actually in on it. His actions make sense for either interpretation, until the end of the movie when [[spoiler:we find out he really didn't know, which is good because someone needed to save Susan's life at that point]].
* AlternateRealityGame: For the miniseries. The Coma Conspiracy website and social networking accounts on one end and the Jefferson Institute [[http://www.cinemablend.com/television/Comic-Con-Visit-Jefferson-Institute-E-Coma-44565.html presence at Comic-Con]] on the other.
* AdaptationDyeJob: Susan is blonde in the novel, but brunette in the film and redheaded in the miniseries.
* BolivianArmyEnding: When Susan wakes up from her operation, much to Dr. Starks' dismay (he had intended to make her his next victim to ensure her silence), the final scene is of him standing in the now-deserted operating room, with the police outside waiting for him. Will he surrender peacefully, commit SuicideByCop or do it himself? We never find out, but either way it's safe to say his career is about to end in disgrace.
* BreakInThreat[=/=]ShameIfSomethingHappened[=/=]TheVillainKnowsWhereYouLive: In the book, aside from breaking into Susan's apartment to threaten her, when the hitman is finished, he shows her a picture of her younger brother, making it clear that he'll harm him if Susan doesn't stop investigating.
* CatapultNightmare: Susan wakes up this way at one point in the movie.
* TheConspiracy
* ConvenientComa: Averted. None of the characters put into comas recover. Although they're not ''technically'' dead, they're essentially the [[AlwaysMurder requisite dead bodies]].
* DeadlyDoctor[=/=]MadDoctor: And ''how''. Starks is essentially killing people in order to sell off their organs without their consent and convincing himself that its somehow all for the greater good when it's really about the money he's making.
* DeathByAdaptation: In the miniseries, Starks is killed by his fellow conspirators.
** SparedByTheAdaptation: Susan, whose final fate is left ambiguous in the original novel.
* EmotionlessGirl: Mrs. Emerson, the nurse running the Jefferson Institute.
* FakeoutEscape: Used by Susan during the Jefferson Institute sequence.
* HeKnowsTooMuch: Or she, rather.
* HospitalHottie: Susan, Mark.
* KarmaHoudini: Lindquist in the miniseries, who's the only conspirator not arrested and is revealed to have escaped to China. It's left ambiguous whether her invitation to Mark to join her was simply working at a new hospital or in starting the entire thing up again.
* KilledToUpholdTheMasquerade: A maintenance worker who was going to tell Susan the truth.
* MakeItLookLikeAnAccident:
-->'''Kelly''': ''[as he's being murdered]'' What'd you do that for?\\
'''Hitman''': They told me to make it look like an accident.
** Additionally, in the book, when he is sent to kill Susan, he is told to "make it look like a rape", as if Susan were the victim of a random street crime rather than an orchestrated hit.
* MedicalHorror
* OrganTheft
* PeopleFarms
* PeopleJars
* RelationshipUpgrade: Susan and Mark merely begin dating in the book, but are an established, cohabiting couple in the movie.
* TeacherStudentRomance: Susan is a medical student in the novel when she begins a relationship with Mark, who is a full-fledged doctor.
* WriteWhatYouKnow: Robin Cook and Michael Crichton were both doctors.
* YouGoGirl: The novel made much of Susan's struggle to be taken seriously in a male-dominated profession. This is toned down and nearly eliminated from the film, in which she's already an M.D.