Bruiser class champions in League of Legends are melee champions designed after the developers realised their melee DPS champions would get annihilated before they could do significant damage. Between naturally high defense and magic resist that scales with level, high amounts of health (and usually a form of life steal), very fast movement speed, a charge or teleport ability or other gap closer and still decent amounts of damage, they are vastly more powerful than any equivalent ranged DPS in terms of stats. Their main disadvantage is that if the enemy DPS is correctly positioned they have to force their way through the entire enemy team and probably die in the process, but this disadvantage only comes into play at high skill levels where players work together as a team, leaving bruisers free to trample unskilled and moderately skilled players.
Jarvan and Lee Sin are the prime examples. The former has a gap closer that spawns a circular wall to trap enemies, a shield that also slows all nearby enemies, a defense and damage buff that affects his entire team, an armor pierce ability that hits multiple targets and doubles as another gap closer (which goes through walls and stuns enemies in its path), and a passive that deals percentage based damage on auto attacks. The latter has a ranged nuke that can also be used as a gap closer and deals bonus damage against weak enemies, a shield that is also a teleport in the direction of an ally and shields him as well and can be reactivated to grant lifesteal and armor, an area effect nuke and stealth reveal that also slows enemies and reduces their attack speed, a knockback that potentially disables multiple enemies and deals major damage, and free auto attack damage after each of his abilities. Considering each champion nominally has only 4 abilities and a passive, the amount of overloading is impressive.
Honorable mention goes to Hecarim, who, while can be easily killed on his own, is healed by any damage done to enemies by allies in a short vicinity, can run through minions, get two pairs of boots in at least one gamemode, with all spells able to be cast while moving. The effect is a champion that can relentlessly chase you into the nexus, if need be, and come out on top, while staying alive despite turrets.
In several games, Bowser has been seen getting around quite fast when he wants to. In Super Mario Galaxy, not only can he outrun Mario, but he actually backflips around the arena. His kin share his agility, most especially Roy and Morton who can leap WHILE within their shells.
The small colossi from Shadow of the Colossus are some of the most frightening and difficult bosses as they are much, much faster than the player and not any less dangerous than the big ones.
The Mighty Glacier characters from some of Capcom's 90's beat-em-ups (notably Perceval from Knights of the Round and Mess from Cadillacs & Dinosaurs) would have the ability to dash, enabling them to easily keep up with the Jacks of All Stats and Fragile Speedsters of the group without sacrificing any power.
Sol of Guilty Gear becomes a frighteningly fast and durable opponent in Gold, and can easily spam his specials, as well as regenerates health constantly.
Berserker in Fate/stay night. Insane strength, surprisingly fast, and has natural armor that can't be penetrated by anything but the most powerful attacks.
The Assassin in Guild Wars. Properly built for PvE, it deals attacks more quickly than any other class, deals more damage than any other class, and is extremely hard to kill. It is capable of doing all of PvE with minimum effort and best time and uses most weapons better than the classes designed to use those weapons — though it is also one of the harder classes to play for non-powergamers. In PvP it loses the resilience aspect to a degree but remains potent.
Addendum: the spirit changes have turned the Ritualist into something like this. It has the second highest damage in the game, can gain a frontline quality armor level, and can shift the spirits constantly to the best position on the battlefield.
Assassins in the original Guild Wars would more fall under Glass Cannon territory. They have no problem dealing out damage, but they aren't known for their ability to take it, and in fact this is why many players find them difficult to play as. However, Warriors who use Assassin skills, such as shadow stepping and dagger combos, in combination with their naturally heavy armor, would definitely qualify as a Lightning Bruiser.
Big Daddies from BioShock. Really big and tough, but also fast and able to dish it out. Especially the Bouncers.
Brute splicers (in the sequel) are just as tough, fast and able to dish it out like the Big Daddies.
Handymen in Bioshock Infinite, being similar to Big Daddies, also qualify. They are terrifyingly agile, deal loads of damage, and are ridiculously hard to kill. When you see a Handyman leap across an entire street block in a single bound to get in your face, you know This Is Gonna Suck.
Duster in Mother 3. His HP and physical attack power are barely second only to Lucas and his speed is barely second to Boney. He even has a special ability that occasionally allows him to get a hit in before anyone else, even if you don't manage a first strike. Balanced by not having any PSI, though depending on your viewpoint that just makes him even cooler. Not just that, he has another ability where if the enemy catches you from behind, there's a chance he'll flip over them before they can act and attack them from behind instead. What's really strange is that he walks with a limp. Imagine how fast he'd be with two good legs.
Garchomp (especially in Gen IV): Better defenses than Swampert, faster than most of its supposed "counters", sky-high Attack, great typing (Yache Berry in conjunction with Garchomp's bulk prevents one-hit K Os with Ice moves, sorry Mamoswine), crazy movepool which allows a lot of attacks For Massive Damage...
Scizor (in Gen IV/V): Steel/Bug typing means that it has plenty of resists (which artificially increase its bulk), it is rather strong, and it can use Bullet Punch to get over its lackluster Speed.
Due to the nature of Pokémon's in-battle stat change system, it's possible for a Pokémon who fits another build trope to become this with the right moveset and/or field condition. Example: Metagross, a Mighty Glacier, can use Agility to become absurdly fast and fit this trope. More absurd examples include Baton Passing Speed and Attack boosts to Bibarel, whose ability lets it double stat boosts it gets (up to +3, which makes Bibarel technically +6; after that, stat boosts don't count anymore).
And then there's Arceus. Having 120 in EVERY stat (which makes it either faster, stronger or more resistant than every other Pokémon), an insane movepool (only bested by Mew, who can learn every TM/HM, and Smeargle, who can learn all but two moves), and, most importantly, can take on any of the 18 types. In short, you can tweak your Arceus to counter, duplicate or best any of the other 717 Pokémon.
Halo's Spartan-IIs, at least in the fluff. Your average Spartan is proficient with all weapons, ridiculously strong, can shrug off terrible wounds, and has reflexes so fast they enter a Bullet Time-like state when in combat — and that's without wearing their trademark Mjolnir Armor, which increases their strength and speed even more. In-game, however, Game Play And Story Segregation results in Spartan characters being Glass Cannons who move only slightly faster than regular humans and can only take a handful of shots before dying messily.
Elites in general are big (even more so than the 7'0" Spartans), strong, tough, and very dodgy; this is reflected even in Halo: Reach's multiplayer, where they have regenerating health, faster-recharging shields, and special evasion moves.
Hunters started as Mighty Glaciers (or Glass Cannons if you attack their weak point), but got faster and more evasive (and even tougher) as the series progressed, taking this trope to its logical conclusion in Halo: Reach.
Defense Of The Ancients: Any agility based hero in a map where you can buy infinite stat-up items. Agility gives attack speed, armor, and if they're agi-based, attack power. So one of these heroes will, when buffed up, high attack power, an absurd attack speed, and high armor. Eventually it reaches the point where the only thing stopping them from instantly killing things is their attack animation, which apparently reaches some sort of attack speed limit.
Syllabear, while being an agility hero, can almost double his HP with his ultimate and attack extremely fast using rabid. The only trade off is his range attack for melee. Medusa also qualifies as an agility hero with mana shield boosting her effective HP.
In Dota 2, Strength Hero Sven gains the ability War Cry that not only pumps his defense up, but also his speed up, making him easier to chase an enemy. If there's an ally nearby, they will also get pumped up with the same bonus.
Warcraft 2, Knights and Ogres filled this role. Good damage, good armor, good hit points, fastest ground units. Then consider Orcs had the Haste and Bloodlust spells. With a good click speed, you could turn your ogres group into a mass of death.
The Tank from Left 4 Dead. At 6000 hp it has the most health of anything and can give a good pummeling, while also being much faster than it looks. The Witch is also an example, in that despite looking as fragile as a standard zombie, it can withstand multiple autoshotgun blasts, is frightfully fast and will one-hit-down any of the survivors.
Some of the super-mutants in Fallout 3, especially Behemoths and Overlords, which are very fast in spite of being the largest (and some of the toughest and most damaging) enemies in the game.
Broken Steel also introduces Feral Ghoul Reavers (the most fearsome enemy in the game hands down) and Albino Radscorpions as part of the quartet of new Demonic Spiders. Both have the same HP as Mutant Overlords but are even faster, have armor-piercing melee attacks on par with Deathclaws, and the former throws explosive gore projectiles.
Investing points in Strength, Agility and Endurance can lead to the Player Character becoming this, especially if you have the top-tier weapons and armor. Strength allows you to hit harder and effectively wield bigger and better weapons, Agility allows you to run faster, jump higher and swing melee weapons faster, and Endurance makes you tougher. This is highly recommended for melee users.
Normal Cazadors are already quite fast, hard-hitting, and durable, but Specimen 73 from Old World Blues puts the "lightning" in this trope, as well as having higher HP than the Legendary Cazador (although less attack damage).
Lanius himself counts as well. He's probably the tallest person in the Mojave, buff enough that he can easily slash you apart with a BFS made from a truck bumper (swords like these are normally wielded by Super Mutants), and fast enough that he'll always outrun you even if you cripple both his legs. Also, he's tough enough to soak up Kill Sat fire, anti-tank rounds and mini-nukes without breaking stride.
A recent addition to the Mass Effect 3 multiplayer is the Krogan Vanguard. Start with their crazy durability and their melee-boosting rage powers inherent to all Krogan classes, then give him the Barrier power and the trademark VanguardCharge, and you have the Murder Train.
Harbinger. He moves faster than ordinary Collectors, has high barriers/shields, and spams a blast of yellow-black energy that deals significant damage.
Commander Shepard him/herself in ME2, depending on your class. Soldiers have Adrenaline Rush, which slows down time around you, and Vanguards have Biotic Charge, which uses mass effect fields (the same things that starships use to travel faster than light) to hurl you across the battlefield through anything in between you and your unlucky target. Both of them can use a shotgun that can shatter a regular human's arms if he/she tried to fire it, and the Soldier can use an anti-tank rifle or a light machine gun. Infiltrators can also use an anti-tank sniper rifle, while receiving significant damage bonuses for stealth and being able to slow time when aiming through the scope, allowing you to empty your magazine into some poor guy's head within seconds. They aren't all that squishy, either.
In Mass Effect 2, the SSV Normandy SR-2 when fully upgraded. By default she's a stealth recon frigate, so she's very fast and agile for a capital ship. Your squadmates can add upgraded kinetic barriers and armor, as well as a main gun reverse-engineered from the weapon Sovereign used to one-shot Citadel capital ships at the climax of Mass Effect 1. Altogether, she's a frigate that hits like a dreadnought or better, with shields and armor to match; War Asset calculations with the Citadel DLC completed put the Normandy at 50pts base, +15 for the Thanix cannon, +25 for the armor plating, +25 for the cyclonic barrier upgrade, +35 for maintenance, +35 for crew morale, putting its War Asset value at 185, or twice the value of the Alliance Sixth Fleet. Admiral Hackett even specifies that the Normandy makes a great "tip of the spear" for engagements; it can move quickly enough to find their strategic vulnerabilities before they react, and it can hit hard enough to exploit those weaknesses.
In Team Fortress 2, the Demoman's Eyelander. It takes off a chunk of your health at the outset, but you get more health and better speed after you behead someone. After two, you're up to above-normal HP and a goodly running speed, and at the maximum of 4, you've got more health than a Soldier and a little less speed than a Scout. Normally, the Eyelander is paired with a shield that reduces certain damage and allows guaranteed crits (which is handy because the Eyelander never gets random crits), but if you take the default Sticky-Bomb launcher and still manage to get 4 heads, you're unstoppable.
With the release of Mann vs Machine mode its upgrade station system, with the right upgrades and weaponry, Scout can deal a lot of damage and yet still exceed the health of an over-healed Heavy while remaining the fastest class in the game. This is because the Scout gains health for any money he picks up. When you have a robotic hoard all dropping wads of cash, some Scouts have been known to get to 700 health, in comparison to their usual 125. The hard part is getting enough health to keep getting health.
Upgrades also include up to a 30% speed bonus and as much as 75% resistance to most damage types. These can end up turning any offensive class into a Lightning Bruiser, besides the Heavy, as there are no upgrades to increase his minigun spinup time or walking speed while using it (besides the general speed upgrade, but the difference is quite small when you're already that slow). Demoman in particular can take this to a crazy degree as said upgrades stack with the speed and health boost from the Eyelander, which is much easier to get kills with due to the large number of robots and being able to shield charge more often with upgrades (which also lets him get around faster).
Video Game/ Lock'sQuest: have Clockwork Brutes, being the second most durable clockwork in the game, having the highest attack, and able to move slightly faster than just about every other clockwork.
Luckily, Lock can be like this too, able to punch out the clockwork army, take the brunt of their assaults, and run back just in time to repair defenses before the clockworks can break through them.
The Brute archetype in City of Heroes has high Hit Points, self-sufficient defenses, and very strong attack sets. The archetype's special attribute is doing more damage the more it attacks or is attacked, making both quick frequent attacks and slow powerful ones beneficial (the former to power up the character so the latter hit extra-hard). It's essentially a class of playable Incredible Hulks. This is boosted even more by taking powers that boost recharge (Hasten, Lightning Reflexes...) or using powersets that recharge quickly like Claws or Dual Blades. The Brute Playstyle amounts to Attack! Attack! Attack! while popping the occasional insp or clicky power. Oh, and sometimes holding aggro is involved.
In Disciples 2: Dark Prophecy, the Defender of Faith, one of the Empire's most powerful fighter units, is a Dual Wielding heavily armored knight mounted on a heavily armored horse. Despite this, thanks to its high Initiative stat, it usually strikes first in each round of battle. He also hits hard. High HP, decent armor, strikes hard, strikes fast, and only takes up one space in the party? The only reason he's not a Game Breaker is that it takes a ridiculous amount of exp and gold to get them in most scenarios.
Another example would be Overlord, from Legions Of The Damned's support tree after his buff in Rise of the Elves. Despite taking two places in a party and an absurd amount of exp and gold, he's durable, hits like a truck, deals additional fire damage and moves at speed of a warrior (50 Initiative).
The Legion's Gargoyle units are just as big as their support units, but they are also just as fast as the other factions' archer units (initiative 60), hit hard, and have heavy armor ratings (Onyx Gargoyle has 65 armor), poison immunity, and mind wards. A party with an Overlord and an Onyx Gargoyle is bad news for any enemy.
There's also Son of Ymir, even more broken than Defender of Faith and Overlord combined. First of all, he's level four as opposed to previous two level five which means he will level up faster. While he takes two places, he has an excellent hp, absurd damage with additional frostbite (sort of poison, but with ice) and, worst of all, the highest initiative in Clans, 50. Only summons and supportive mages tree have higher IN.
Though all of the superdragons could count, Heroes of Might and Magic's Crystal Dragon is probably the best example. It's fast enough to out-speed almost everything in the game, is insanely difficult to kill and packs an obscene amount of damage. The only saving grace is that - unlike most dragons - those aren't immune to magic, which allows you to cripple them down and make fight noticeably easier.
Gabranth's gimmick in Dissidia: Final Fantasy is to charge his EX Gauge so he can enter EX Mode quickly. "Lightning Bruiser" doesn't describe Gabranth's EX Mode accurately enough though, a better term would be primal force of destruction. He moves and attacks quickly and his combos are incredibly powerful, and in addition to brute strength a lot of his attacks can crush guards, combo without hitting, or deflect projectiles. This is all on top of the normal EX Mode bonuses of regenerating HP, increased chance to land critical hits, and the ability to use an EX Burst.
Iron Tager was a Mighty Glacier in Calamity Trigger, but speed buffs in Continuum Shift are shifting him in this direction. Similarly for Hakumen. Then the trailer for the PSP version came out with Unlimited Tager...
"I told you I can get him across the screen in thirty frames."
Whereas Ragna the Bloodedge is normally a Glass Cannon, Unlimited Ragna not only deals more damage and is faster than his normal self, but has the health to out-tank Mighty Glacier/Stone Wall Tager even before taking into account his life-draining Drive attacks. His health was nerfed to more tolerable levels in Continuum Shift, but that's all the downgrading he got.
The Rex Wheelie from Kirby Air Ride Star is a Bulk Star with more speed and acceleration, doesn't have the need to refuel, has a lot of HP, Defense and attack and is HUGE. Also, being a wheel based Machine and therefore always on the ground, it jumps high off ramps and automatically activates the special buttons and panels (i.e. Boost Panels) on the floor. Balanced by being quite hard to steer.
Samus of Metroid counts. She's a power armored badass that can soak up damage like a sponge, is death at both melee and range, and is capable of reaching mach 1.
Hunters from Half-Life 2 Episode 2. Large tripod-ish killing things with impressive speed (they can outrun you, period), an array of deadly weapons, and a lot of hit points - it can take multiple rockets to kill one, depending on difficultly, although the Pulse Rifle altfire is a nice one-hit-kill solution.
The Tyrants from the Resident Evil series; with the Nemesis as their undisputed king. Generally, they start off slow, hard hitting, and resilient. Then, when you piss them off enough, they get a speed boost. And they are faster than you.
Mendez, The Brute in Resident Evil 4 can also flash step, bend metal, kick the crap out of Leon like a ragdoll, and is resistant to bullets. The Mercenaries minigame has Super Salvador, who is as fast as the player, can leap rooftops in a single bound, and will instantly decapitate you with his flailing double chainsaw the moment you get in punching range. Verdugo, the illegitemate love child of Tyrant and the Predator, is even faster and deadlier than the Tyrants, and is Nigh Invulnerable unless frozen with liquid nitrogen.
Series Big Bad Wesker can move faster than the eye can see, punch straight through a man and regenerates fast enough to be almost immortal. Best shown in his boss fight where he will block an RPG coming from his blindspot to a standstill and the thing exploding in his face only disorients him for a few seconds.
Raid Mode of Resident Evil: Revelations has the enemies with the purple crown symbol, who combine the traits of the fast, defensive and strong enemy types, with none of the weaknesses.
Scagdeads, who run fast, hit like a ton of bricks and have a high HP. Even the defensive types that usually are slow Mighty Glaciers move fast.
In Resident Evil 6 we have mutated Derek Simmons. His first and relatively small form can effortlessly keep up with speeding trains while tearing them apart and eventually derailing them in a single swipe. His second form is much larger and stronger, but only slightly less agile. And he comes back for more seven times, each time shrugging off the punishment you inflicted on him last time, to the point only repeated lightning strikes do any lasting damage to him. Subverted with his final form which is humongous but barely mobile.
Doom has many units that fit different parts on the scale of Competitive Balance but also has Hell Knights, Barons of Hell and Cyberdemons. Hard hitting on ranged and melee, good health and also surprisingly fast.
Guardians in Uncharted 2: Among Thieves are one of the most unfair examples of this trope. Not only are they big, strong, fast, and capable of leaping absurd distances, they're also Immune to Bullets when you first meet them. Even when you do get the opportunity to actually kill them, they still absorb enough rounds to turn a small army into salsa and ask for seconds. Oh, and they also fire some of the most accurate and damaging weapons in the game. Good thing you never have to face more than three of them at a time.
Kain from Legacy of Kain. A vampire with superhuman strength sufficient to move boulders weighing several tons, superior speed, agility, and reflexes to mortals, and skin tougher than a suit of armor.
Bacchus from Star Ocean The Last Hope, His strafing attack moves him quickly along the ground and hits twice. If you add More Dakka through Item creation, it actually becomes more powerful than his special attacks (which are already some of the best). He also has high Defense and HP. As well a skill that lets him heal 50% of his hp instantly.
Warriors Orochi gives us Orochi himself, who is a Game Breaker on so many levels that they deliberately deny unlocking him (and his upgrade, Orochi X) until the very end of the game. He's large, powerful, moves fast, hits hard, and unlike almost every other character in the game, has automatic immunity frames in some of his moves where he can pummel the opposition without worry or cost.
Assassins Creed IV: After some upgrades, it can be easy to forget that the Jackdaw started life as a humble brig (i.e. the lowest tier of medium ships in-game). By the endgame, it can match the firepower of a Man o'War while sailing circles around it and practically shrug off return fire. Frankly, the in-game "legendary" ships don't hold a candle to that monster.
Laharl for Disgaea: Hour of Darkness, Adell for Disgaea 2, and Champloo for Disgaea 3; all 3 of these characters sport exceptional close combat strength, a good set of specials, and exceptional power, defense, movement range, and, for the really exotic on their specials, decent intelligence and resistance to magic. If played right, all one would ever need to complete Disgaea 1 is Laharl, a sword, and a few decent playthroughs of the item world, and he could take on the entire game himself save for a few team oriented stages. Adell can match Laharl (mainly due to his ability that gives him added attack power for units stronger than him) and while Champloo falls a tad short of both, he is almost still guaranteed kills when just within a few levels of his opponent let alone even or higher.
In Dragon Quest VI, Carver very much fits the fast+hard hitting+can take damage description.
Oda Nobunaga in Sengoku Basara is another example; he has the second-highest HP, attack and defence in the game (after Tadakatsu), almost as good movement speed, and attacks much faster than Tadakatsu with non-telegraphed attacks that don't move him. He also uses the powerful Shadow element, and his special arts are much more powerful than Tadakatsu's, including a super art that renders him invulnerable. Nobunaga is only unlocked as a Bragging Rights Reward and is Purposefully Overpowered.
Sasquatch from Capcom's Darkstalkers series. Though he possesses the second-highest health in the game, deals heavy damage, and has a large hurtbox, the Canadian yeti also boasts some excellent mobility in the form of "shorthops," canceling his dash (a hop) short of finishing. This grants him some frightening mixup games that lead to devastating, yet simple, combos, and is a large reason why he is arguably the best character in Vampire Savior (the most commonly played title in the series) and Night Warriors.
Doku from Ninja Gaiden. A towering Animated Armor with a fair bit of health, his slashes come out fast and hurt a lot, and while his Deadly Lunge is telegraphed, if you don't immediately evade he'll eat the distance like a glutton at a buffet and make you pay. His spirit form is even worse.
Glenn from Chrono Cross, once he gets his hands on the Dual Einlanzers, will outdamage everyone else while still having good defenses and speed.
Many late-game bosses in Fire Emblem fit either this or Mighty Glacier. Case in point, Ike's recurring enemy the Black Knight is repeatingly described as abnormally fast for a guy in heavy armor and the strength to match. He is more of a Mighty Glacier in the sequel but that is only relative.
Trueblades, the class that Swordmasters turn into after level 20 in Radiant Dawn, could also count, especially Mia. They have a ridiculous evasion rate, hit their target most of the time, and between all of their offensive stats you'd be hard-pressed to find anything short of a mini-boss or boss that can survive more than a single round with one; usually they'll end up getting killed by critical hits or their Astra ability. One of the best examples is Stefan in both games. He has high base stats and retains the class line's advantage in speed and skill, but for story reasons, he also has unusually high growths in HP, strength, defense, and resistance. In Path of Radiance he was held back by his abysmal luck score. In Radiant Dawn he's all but guaranteed to max HP, strength, skill, and speed, has a very high chance of maxing out defense and resistance, and unlike other characters with this potential, he does not need to depend on Save Scumming or manipulating bonus experience. As an added bonus, his Heaven affinity ensures that supporting him with anyone allows him to reliably use the otherwise very inaccurate ranged swords. The only things preventing him from breaking the game is his late joining time, and the stat caps of the Trueblade class.
In Fire Emblem Awakening Chrom certainly fits this as he starts leveling up, dealing insane damage, usually attacking twice and being able to take hits. Upon promotion he gets Aether, like Ike, which he can use to soak up even more damage as the first hit drains health, and also dish out damage as it turns what would normally be a single attack into 2, with the second hit ignoring half of defenses. Play your cards right, and all of the second generation characters can become this. Special mention goes to Galeforce, which, provided you can kill an enemy in round, lets you move twice in one turn, making it possible to get twice the action done.
In Sonic Unleashed, Sonic is able to move fast, destroy tough enemies, and lose only 20 rings per hit.
Oswald the Shadow Knight, from Odin Sphere. Strongest, toughest character in the game, with good speed and jumping power. Also hits even harder and moves faster when he uses his Shadow Form. Other characters in the game are capable of blocking for highly increased damage resistance or have ranged normal attacks, and some special double-jump power, like flight. Oswald's just meant to rush in and rip things to pieces.
Citan from Xenogears. He starts off as a Bare-Fisted Monk, with the highest speed and HP of all the characters (plus, enough attack power to compete with a weapon user). But then, as if he wasn't broken already, he eventually gets a sword, making him the strongest character BY FAR.
Dante from Devil May Cry looks like a built human but can take a beating from giant demons, strike fast and hard and his Super Mode increases his speed and strength and gives him a Healing Factor. Many of his bosses follow his hit hard, fast and take a beating skills, particularly the Mirror Boss of the game.
Sephiroth's appearances in the Kingdom Hearts games count: he's got multiple health bars, beyond insane reach with that sword of his, is as fast if not faster than you, and swipes significant chunks of your health everytime he hits you - and he will hit you.
The Demon Knight in Dragon Quest I dishes out massive damage, has high defense, is magic-proof, and has the highest agility of any enemy.
Wild ARMs 2 has the protagonist Ashley Winchester who fits this trope like a glove. Even though his build is average, he's got pretty good HP, can be insanely fast even without his Accelerator Force Action, can deal good damage, and yet wields a bayonet that looks like a BFS. And that's not even getting into his Superpowered Evil Side.
Arch-Viles in the Doom series are fast, can take tons of damage, are resistant to flinching, attack with a deadly line-of-sight fire spell, and can revive or summon enemies.
Roy in Super Smash Bros. Melee applies, as he is a character with great power, speed, and durability, but is actually lacking in other areas specific to the series, such as low range, bad recovery, and heavy falling speed.
Lancer, also from Fate/stay night. He's the fastest hero and also the best defender, thinking nothing of fighting over several other heroes at once (though Assassin unnerves him somewhat). Also has a cheap instant kill attack, powerful magic and a primary limitation of being unable to win the Grail War because not only is he not a protagonist, his Master won't let him win either.
Heroes of Might and Magic: In the third game, Crusader. Is able to sprint through half of the battlefield in one sweep (or even the whole thing with the right enhancements), packs high ATK/DEF stats, decent 35 points of hp and attacks twice. You can also usually get them as fast as on Day 2. On the other hand, they're pretty expensive.
From the same game and castle, Halberdiers. Though they're only Tier 1, they pack an obscene amount of damage, they are resistant to damage, immune to Cavalier's charge bonus and pretty fast. Since AI prefers to attack other units(namely, everything else), you can easily accumulate a vast amount of those guys and proceed to beat things into a bloody pulp.
Princess/Tsarevna Alena from Dragon Quest IV can be considered this. Starts gaining a LOT of Strength and Agility early on, and maxes them out around level 52 or 53, and because of the way Resilience is gained in the early DQ games (namely, at precisely half the rate of Agility), she's got the highest base defense to boot. Whether or not her average HP and subpar equipment options put her here or in Fragile Speedster territory is up for debate, but she still hits MUCH harder than anyone else on the team with normal attacks. On the offense side of things, she's boosted even further by the fact that her best weapon lets her hit twice per turn.
Hyperdimension Neptunia mk2 has the protagonist Nepgear herself. She's pretty fast, deals a lot of damage, and can hold on her own ground because she can take a lot of punishment. The one thing that makes her a Game Breaker? She has to be placed in support role because the only way you can get rid of the Damage Cap throughout the entire game (unless you defeat and acquire the rare item from the highest leveled Bonus Boss of the game) is by placing her as support.
In Hyperdimension Neptunia V, Neptune became this, graduating from her status as a Glass Cannon in the first two games especially in HDD. Good tank, deals quite a bit of damage, is fast enough, and has a lot of attacks to choose from, already breaks the damage limitwithout having Nepgear as support, and that's no including her multiple combo attacks with her partners. Her problem however is that Noire still outdamages her thanks to Noire ignoring enemy traits, she can't heal (which in a Nintendo Hard game, is pretty bad), and almost has no debuffs to choose from.
Ace Combat late or endgame planes and the superfighters embody this trope. Fast, agile, able to take at least two missile hits (on Normal), armed with plenty of regular missiles and loaded to the gills with special weapons galore.
In Ace Combat 6: Fires of Liberation, the early game A-10A can surprisingly also fulfill this trope for some time, thanks to the highest Stability and Defense rating in the game, the FAEB being probably the best air-to-ground special weapon in the game (certainly the best unguided free-fall bomb) and a surprising ability in a(n early game) dogfight... at least within infinite ammo tankbuster cannon range.
The ADFX-01 Morgan from Ace Combat Zero: The Belkan War is blazingly fast, highly maneuverable, has excellent defense, and can mount as weapons a tactical laser system that can destroy even the most hardened targets in the game with as little as 2 seconds of sustained fire, an EMP jammer that when active will temporarily deflect ALL attacks, and a small-scale version of the Burst Missile from Ace Combat 5: The Unsung War, which has a slow reload time and limited ammo but creates a wide-range explosion capable of killing entire squadrons in a single shot. "Game Breaker" doesn't even begin to cover it.
And both games' Spiritual Successor, Vector Thrust, boasts an entire family of Lightning Bruisers in the form of the F-15 Eagle family. Eagles are extremely fast with impressive agility only outperformed by 5th generation aircraft and the Su-27 family, as well as above-average defensive abilities when compared to their smaller F-16 friends. They also boast formidable arsenals ranging anywhere from multi-targeting, long-range missiles, cluster bombs, and all-aspect munitions.
Ialdabaoth in Super Robot Wars. It's a Super Robot, which grants it a good dose of defense, yet it's fast and hits almost as hard as other big guns like the Dygenguard. The pilot can up the ante of damage 2.5 times.
Valzacard. Size LL means it takes less damage and hits damn hard, but because its main pilot spent a lot of the game in the Real Robot Valhawk, there's a good chance it dodges at least as well as some of the tiny Gundams on the team. And half its pilots have the dodging and damage-dealing Spirit Commands of a Real Robot while the other half have the support and defensive Spirit Commands of a Cool Ship.
Either Angelg or Vysaga fits this, in the same vein of Ialdabaoth. They hit really hard, are quite tough, considered Super Robot and have mirror image that lets them dodge, and activates often. Angelg is even noted to be one of the fastest mechas amongst the good guys.
So is GaoGaiGar. Protect Shade/Wall (and later Genesic Armor) let him handle armies of mooks, no trouble. Genesic Aura, Guy's stats, and the base power of Hell and Heaven/Goldion Hammer/Goldion Crusher let him deal tens of thousands of damage unaided. Brave and GaoFighGar/Genesic GaoGaiGar's stats let him dodge at percents that are poor for a Real, but ridiculous for a Super. Truly he is the Destruction God.
Again, The O. It's sometimes unlockable as well and it has very good armor, speed, and power for an MS.
Demonbane has one of the highest HP pools and armor value in Super Robot Wars UX, hits like a truck, and possesses the "Mirror of Nitocris" ability note Grants a 30% chance to dodge all attacks.
Super Robot Wars UX also has the Odyssea, which comes with large EN regeneration, does not use EN for movement and ignores terrain that penalizes movement, alongside its "Space Jump" ability note Grants a 35% chance to dodge all attacks. Its final attack has 1000 more attack power than most Trans-Am attacks. However its evasion isn't that good, so it's closer to a Mighty Glacier.
Basic tanks in the early Command & Conquer series. In addition to being able to dish out and take far more damage than infantry, they are also much faster than them, which often leads to the games being all about massed tank rushes.
MechWarrior Living Legends has many lightning bruisers among its Heavy Battlemech class, but by far the most terrifying mech in the game is the Fafnir "Foxtrot" variant, which is simultaneously the heaviest (100 tons, Assault class) mech, most armored, most dangerous, and the fastest Assault mech in the game. Other Fafnirs are stuck plodding along at 53kph - but not this one, as it carries MASC which can ramp up its top speed to 75kph, enough to catch anything besides a Light mech. It carries a pair of Ultra Autocannon/20s, rapid-fire murder cannons that can rip armor to pieces in seconds, and to top it off, it carries tenflamethrowers, enough to roast enemies to the point where their reactor goes critical. Luckily for the enemy team, the Fafnir Foxtrot is just as dangerous to itself as it is to its enemies, courtesy of its weapons and MASC putting out some truly astonishing amounts of heat which it has few heatsinks to deal with, leading to many of the mechs melting to death in the middle of combat.
Star Trek Online has finally introduced the Excelsior class cruiser from the Star Trek movies and TV shows. Whereas all other cruisers are best classified as The Mighty Glacier with a slow turn rate, nigh unbreakable tank and moderate offensive abilities, the Excelsior can tank only slightly less effectively while it has access to much higher level offensive powers. It can also turn much faster than all other cruisers in its tier, making nearly as agile as an escort class (think Defiant) with almost as much firepower. This is after Cryptic planned to give it equal defensive abilities to other cruisers and higher level science abilities too which would have boosted its tank even more or given it crowd control abilities on par with science ships. Even fans of the ship complained that this would make it an utter Game Breaker, forcing Cryptic to tone it down to the moderately overpowered level that it is now.
Temjin and the Viper series in Virtual-ON, with Temjin having better armor and the Vipers greater speed and weaponry. The Apharmd model also has great agility on par with the Temjin, slightly better defense, and good hitting power, with its main limitations being the small clip size for its shotgun and the need to get close to properly employ its extremely powerful laser tonfa.
The higher stages of the tech tree in Galactic Civilizations II allow you to build massive battleships, fitted with maxed-out hyperwarp drives, carrying enough missile launchers to take on a fleet solo and covered in armor plates. The main drawbacks: it'll either take years to build or cost a fortune, and getting your research up to that stage takes absolutely ages, and due to the Tactical Rock-Paper-Scissors nature of weapons, ships with the right equipment can eat it alive. On the other hand, it is just so cool to lay waste to entire Drengin fleets with a single missile-encrusted cruiser.
In the Twisted Metal franchise, several competitors may count, but the best example is probably Minion, a demon who drives a Cool Tank. The tank is as nearly as fast as the game's Fragile Speedsters and has top-tier armor and a devastating special move as well; it's one real weak point is its size; since it is so large it is easier to hit than some other vehicles. In most games where he's playable, Minion needs to be unlocked.
Despite what his stats might imply, Dave's '70 Van in the original Vigilante 8 qualifies as this. He's got good stats with a heavy slant to armor and his top speed while going in reverse is actually faster than going forward. What really makes him powerful though is having one of the most powerful specials in the game - it does tons of damage from anywhere and it's highly accurate, so you can stock up on specials and destroy enemies without having to get anywhere near them. In the second game, Dave's cultists no longer qualify as they're quite a bit slower and this special attack's been toned down heavily by making it more inaccurate the farther you are from the target when you use it.
The TIE Defender from the Star Wars game TIE Fighter can withstand more punishment than a bomber, can easily overtake a dedicated dogfighter, and still manages to pack four lasers, two ion cannons and two high capacity missile launchers. It is then taken Up to Eleven with the Missile Boat, which is even faster with four higher capacity missile launchers, with the only drawback being one laser cannon.
The Loa introduced in the sequel's expansion have durability of the Hivers, guns of the Zuul and acceleration and speed no organic race can match.
Meracle from Star Ocean The Last Hope is at first glance a Fragile Speedster, but with No Guard equipped, she turns into this. She's fast, she hits hard, and since she has high HP, she can more than take a hit.
World of Tanks has a few: the AMX 13 90 is a tier 7 light tank, so it is small and has the speed of a light tank, but the health points in the 4 digit range like the other tier 7 heavy and medium tanks, also it has a gun with a 6 shot magazine which can dish out a lot of damage in very short amount of time, putting it even further apart from other light tanks (which are either starting tanks in the lower tiers or dedicated scouts). High tier medium tanks can come up like a Lightning Bruiser too if played well.
The tier 9 T-54 is particularly notable, having a solid hitpoint pool, thick armor (especially on the turret), high top speed, fast traverse on both turret and hull, and an optional top gun that has a very high damage output.
Polaris ships in EV Nova. All of them. Special mention goes to their Manta fighter, a fighter which A) is the fastest ship in the entire game, B) has just under twice the shielding and armor of any of its counterparts from the other governments, and C) mounts a main gun worthy of a light capital ship.
The Big Bad of Mortal Kombat, Shao Kahn can hit fast and hard and takes far less damage than you do. Couple with Perfect Play A.I. he attacks relentlessly, blocks most counters and shrugs off what makes it through. Thankfully he doesn't see the problem with taunting in a fight.
The upgraded Edelweiss in Valkyria Chronicles can move farther than most enemy tanks, has a powerful main cannon that can oneshot them if it hits a weak point and possesses enough armor to shrug off a lot of return fire.
The namesake Valkyria such as Selvaria and Alicia can traverse half the map and absorb alot of enemy return fire while doing so. With their signature lance and shield they can ignore any fire thrown at them and oneshot tanks.
If it's an air-combat simulator set during World War II, the late-war American fighters tend to be this. Especially simulators set in the Pacific, where American fighters were almost as a rule faster, tougher and better-armed than their Japanese opponents.
Arc The Lad has Choko, who can move about twice as far as other units, deals at level 1 about as much melee damage as Tosh at level 60, and, although the maximum HP is not as high as expected, her defense is also the best from the playable characters in the game. However, she has no magic, and thus is unable to make use of the game's broken Romancing Stone accessories. Plus, she cannot be used in battles that advance the story.
The Old Republic has a pair of options for this in each faction. Operatives and scoundrels (Imperial/Republic respectively) can both wear medium armor and have high mobility coupled with hard-hitting damage output at close range.
Naval Ops: Warship Gunner players often build Lightning Bruiser battleships, because at the later missions and on the New Game+, a well-balanced battleship with heavy firepower, good protection and good speed is crucial.
Civilization V: In the Brave New World expansion, the Zulu Impi, when given all special promotions, has 3 move, a giant reduction to incoming ranged damage, increased strength, and does a "spear throw" before its melee attack (which, in addition to dealing more damage without being hurt, also boosts XP gain). It also gets a bonus to flanking attacks (ie attacking when you have other units next to the enemy). When upgraded to riflemen, it keeps all of this except for the spear throw.
Tzar The Burden Of The Crown has a few examples, the most prominent one being all mounted units (except Horse Archers who prefer Hit-and-Run Tactics and Chariots who are mobile Stone Walls instead). All of them boast above average values of health, attack and defense as well as moving faster than infantry units. Their weakness is their crippling inability to deal with Pikemen/Spearmen/Samurais who deal bonus damage against them and the fact that almost all of them are end-game units that require specific steps to be accessible(European Knight and Arabian Heavy Horseman are exceptions from this rule).