Connor from Angel is this, due to being a Dhampyr. Other Buffyverse characters could be described as this too, but Connor is notable because his fighting style is designed to exploit this as much as possible. (unlike, say, Buffy, who, as a Slayer, is supposed to be this, but draws on her power way more than her speed or her durability)
The White Star-class gunships in Babylon 5. Thanks to a combination of Minbari and Vorlon technology, these comparatively small ships pack quite a punch and have the maneuverability of a fighter. They're also the only ships of that size that can open their own jump points. They're far from invulnerable, though, and many are lost during the Second Shadow War and the Earth Alliance Civil War. Also, compared to the cumbersome EarthForce ships (no Artificial Gravity or Reactionless Drive) during the Earth-Minbari War, the much larger Minbari ships were this. And let's not forget the Vorlons and the Shadows.
Deadliest Warrior: The Samurai. Much more agile and precise than the Viking and later the Spartan, his katana and especially his kanabo meant he hit like a truck despite his size, and his steel armour was quite resilient as well. Also, the Vampires from the Season 3 finale were much stronger and faster than any human could ever hope to be, and also would survive injuries that would kill humans outright.
Brienne is both very big and strong (the actress who plays her is 6'3" in real life) and very fast (after losing her weapon in the melee, she is able to defeat Loras by ducking inside his defenses and tackling him to the ground before he can bring his weapon to bear to defend himself).
If you are stronger than Sandor Clegane, he will be faster and more skilled. If you are faster or more skilled (there are almost none who could accurately claim both), he can simply brute force his way past your defenses. This is how he's become such a feared swordsman, and how he stands toe-to-toe with Gregor at the Tourney of the Hand.
Bronn describes Sandor's brother Gregor as "freakish big and freakish strong and faster than you'd think a man of his size." Though after Qyburn's treatment he seems to have lost this aspect, becoming more of a Mighty Glacier.
Drogon. As big and great as he is, this Dragon has very quick and sharp reflexes. Even when Dany was a sitting duck and hadn't fully removed the ballista bolt, Drogon quickly swivels his neck and lights up his throat to burn down Jaime.
The Flash (2014) has the Reverse-Flash. He's a lot faster than Flash himself and he's strong enough to toss grown men around like rag dolls. Season 2 introduces Zoom who's even faster and stronger than Reverse-Flash. Zoom runs circles around Flash and then effortlessly breaks his back. Season 3 continues the trend with Savitar, who is absolutely huge and strong enough to toss Flash around like a rag doll, and so fast he makes Flash look like he's in slow motion.
Eliot Spencer in Leverage. The guy Does Not Like Guns (but is still a pro at using them). His introduction involves a flashback of a retrieval mission in the den of some mob boss with a dozen of the latter's guys armed to the teeth. A few seconds, and tons of gunshots later, we are once again shown the inside of the den with all the guys down and Eliot unharmed. In the same episode, Eliot takes out two professional security guards before a dropped bag hits the ground.
Gannicus from Spartacus fits this. He's one of the smaller characters, prone to bouncing around everywhere, but it takes and incredible amount of damage to knock him down and is shown to be surprisingly strong.
The Borg Cubes are utterly massive and dwarf any ship Starfleet fielded in the TNG era. They're also insanely fast. The U.S.S. Enterprise (another contender for this trope) was in danger of damaging her engines when giving chase to a fleeing cube.
Clark Kent, naturally, on Smallville. This version has no compunctions about dropping into 'Clark time' and using his superspeed to take opponents out.
Castiel from Supernatural is this, relative to his human friends. Due to his angelic powers, he can dish out and take significantly more damage than Sam or Dean and bounce back from injuries much more quickly. In one episode, Dean has him move a very large anvil for them; in another, he slices a magical sigil into his chest and then engages in combat with no ill effects from the injury. He can also teleport, allowing him to appear suddenly behind or in the pathway of enemies before he smites them. Relative to other angels, however, he's either stronger or weaker depending on the rank/power level of whomever he's facing off with. Archangels can generally kill him with a fingersnap.
Wonder Woman: Wonder Woman could stop a tank with her bare hands and rescued soldiers by throwing a telephone pole at the bad guys. She could also run over 700 mph (shown in "Death in Disguise") and, for example in "Flight to Oblivion", chased down a bus and stopped it by grabbing onto the back bumper and overpowering the engine.