In the Mass Effect/Command & ConquerFusion FicRenegade, GDI soldiers — particular Zone Troopers — are tremendously heavy-hitters and mobile thanks to strength-enhancers and jetpacks. There's also the Scrin Intruders, and on top of that, Locke, a massive slab of humanity who is described as moving as smoothly and swiftly as if he were naked, not clad in a half-ton of massive power-armor.
ChaosGallantmon, Daemon, Gallantmon Crimson Mode, the Nightmare and Terriermon from the Tamers Forever Series are all lightning fast Mega digimon capable of some of the most utterly devastating attacks in the series.
From The Wizard in the Shadows Emrys falls into this category. He moves like lightning, kills trolls in less than five seconds, but he can take hits too.
The Reapers fit the trope—until the Trans-Galactic Republic shows up with its Star Destroyers. If Faster-Than-Light Travel is considered, hyperspace far outclasses eezo drives without mass relays, so depending on what is being measured Star Destroyers may also fit here.
When the heroes build anti-Reaper ships, they aim for this trope, but end up with Glass Cannonsinstead.
Samantha Shepard fills the niche too (as most portrayals of the character do).
So is Diana, who can fly, match a large Asgardian boy two years older than her for strength while outmanoeuvring him, which only makes sense since she's a pre-teen Wonder Woman.
Thor, naturally, who is regularly noted to be capable of moving far faster than most believe possible (plus his Shock and Awe powers make him a literal case).
Among many other things, the Winter Soldier is extremely fast.
By Ghosts of the Past, Harry's in this category - he moves extremely fast and hits incredibly hard.
Ogres from XCOM: Second Contact are stronger, tougher and faster than even Wrex, who is himself this to most of his comrades.
Zephus-Hassan from The Legacy Of The Blood Ravens is a ten thousand year old assassin. With power armor and an already enhanced biology, he is considered the most dangerous enemy the Blood Ravens Space Marines face in the story. Common battlefield strategy when facing Zephus-Hassan is a general withdrawal.
John Freeman, in Half-Life: Full Life Consequences, is revealed as one of these in Free Man. He is capable of "killing combines with bear hands," withstanding "masheen gun" fire, and can "walk fast like the speed of light."
Several in The Bridge. Rainbow Dash as a renown speed flier but is also tough enough to last in a fight against a dragon. Princess Luna and Cadance both use a mix of their alicorn gifts, earth pony strength and pegasi flight to prove their roles. On the kaiju side, Monster X uses a martial arts training and gravity manipulation to perform feats such as back flipping onto and running along walls, while also being arguably the most durable and physically strongest kaiju on his team.
In A Horse for the Force, Ranma can block lightsabers for brief periods with his ki shields and tank blaster shots, along with being fast enough anyone not extremely skilled in Battle Precognition simply can't keep up and strong enough that the shockwave of a stopped punch can slam a person's head into a wall hard enough to crack said wall.
In Aesir: Cross Wars, Azrael is really the only protagonist to qualify. He has amazing Magic Defence, good Speed, and average to slightly above average offensive stats. However, he can't take physical moves well.