Doomsday, the beast that almost killed Superman in his debut. While he's decayed somewhat, he is still a nightmarishly durable behemoth who is stronger than even Superman and can keep up with him.
Vartox. While in modern comics he has powers roughly equal to Superman's, Pre-Crisis Vartox was the Always Someone Better, with strength, speed, durability, senses, etc far superior to Superman's.
Batman: Bane, the man who broke the Bat, is built like a truck (and that's before using his Super Serum Venom) and not only faster than he looks, but smarter, too. While his speed isn't anywhere near the upper reaches of the DC echelon, he's a incredibly fast and strong compared to the majority of Batman's rogues gallery.
The Incredible Hulk is not only the strongest one there is and nigh-invulnerable, but he's also extremely fast. So is his lover, Betty Ross, when she was Harpy and Red She-Hulk. During the Superman / The Hulk crossover, Superman attempts to grapple the Hulk to calm him down, only to find himself almost instantly flung into space, causing Supes to remark, "How can someone that big be so fast?"
The Juggernaut, bitch. He can run at a top speed of 111 miles per hour, can run through anything, and does not tire.
Beast of the X-Men is incredibly strong (capable of going toe-to-toe with Iron ManDepending on the Writer) as well as incredibly fast and agile, thanks to his ape-like physique, which also makes him much tougher than your average human (or even mutant, for that matter).
The Flash, whenever the writers don't forget how much it sucks to be punched by someone going that fast.◊ This has varied over the years, and still varies with the writer. In Wally West's first hundred issues or so, he could usually hit no harder than a typical athlete — his aura absorbed most of the energy. As the editor pointed out, Wally would break his hands with every punch otherwise. When the Speed Force was introduced, it quickly became a catch-all answer to physics gripes; thus Wally's been delivering super-punches again, apparently using the Speed Force to sneak around Newton's third. However, all Flashes have the durability part down pat, because of their Healing Factor.
The Mighty Thor is insanely strong - no one's quite figured out whether he's stronger than the Hulk, but he has a good chance, and he's gone toe to toe with Superman and the Martian Manhunter in the past and come off the better (though he later lost to Supes, as Supes knew he could take the heavy stuff. Thor didn't know that Supes could take it as well as dish it). He also flies at FTL velocity and moves fast enough to tag speedsters breaking the sound barrier.
Thor is especially notable since Marvel's superheroes are generally much weaker than DC's. While Superman is extremely strong, fast and tough, so is EVERYONE in DC. Thor is a planetbuster on a planet where most strong characters (Thing, Colossus, Rhino, Iron Man, etc) can maybe lift a mountain at most, he's multiple times faster than light with intergalactic teleportation on a planet where most fast characters can barely break escape velocity, etc. Especially notable is the fact that everyone strong enough to fight him (Juggernaut, Hulk) is nowhere near fast enough to lay a hand on him, cannot fly, and has crappy ranged attacks. He also has planetary scale weather manipulation (stronger than Storm's) and magical power greater than the Silver Surfer's. Unlike Superman he has no weakness. It's pretty astounding just how much better Thor is than almost anyone else on Marvel Earth.
The Incredible Hercules, who's as strong as Thor, if not stronger (Banner notes that if he'd really tried, he'd have taken down the Green Scar Hulk on his own), his superior at hand to hand, and fast enough to tag Marvel's Superman analogue (who, admittedly, was trying to talk Herc down) The Sentry with a Venom covered fist. Herc's only weakness is his inability to fly, unlike Thor and Sentry, but he's quick and agile enough that it usually doesn't matter.
Marv from Sin City is capable of avoiding gunfire, running after cars, and has even used a fair bit of agility to take down two different groups of SWAT teams. All of which defies his massive size and allows him to take down the agile and deadly Kevin, Goldie's murderer.
Violet from Rat Queens is a pretty redhead who is shockingly fast for her size (she's a dwarf) and packs an amazingly large arsenal of swords and other assorted implements of destruction.
Most mimic characters can turn into this: the Super-Adaptoid, for instance, is as fast as Quicksilver and as tough and strong as Hercules, and Amazo has Flash's speed and about four different kinds of Super Strength.
While Spider-Man isn't near the upper-echelons of power in comic books, among the "street-level" heroes and villains he usually interacts with, he qualifies. He can lift 20 tons over his head, has enhanced reflexes and speed (not to mention that his webs enhance his mobility considerably), and his enhanced musculature gives him superhuman durability and endurance, which is further enhanced by his status as a determinator.
The Kingpin. A lot of people mistake his considerable size as being fat. In reality, it's all hard-built muscle and he's spent decades training himself in hand-to-hand combat. In their first confrontations with him, both Spider-Man and Daredevil made the same mistake of assuming that Fisk was a Mighty Glacier, only to be caught off guard by how fast and durable he is.