In the lonelygirl15 video "Truth Or Dare", the "random girl" asks, "Do you guys film everything?"
Then there's Bree in "New Girl": "You know, you'd think that maybe, just, just, just maybe, the Order would crack down on webcams. Idiots."
This exchange from the Kate Modern mid-season 2 episode "Who Killed Kate?":
Alice: Yeah, it's a bit far-fetched, isn't it? Sophie: Well, no more than life-extending blood drinking rituals and secret world-controlling societies!
Jonathan: Wait, that makes him a supervillain. Travis: ... Actually, that's true. Which is pretty cool — I hadn't thought of that. I guess that makes us superheroes.
Shelton: This simulation is a little unrealistic, isn?t it? Tinner: What do you mean? Shelton: Some enemy army invades the base? There's no way that would ever happen. ::That last quote basically sums up Darwin's Soldiers.
The Nostalgia Critic performs a lampshade in the Captain N episode. "I mean, who would be so lazy as to show nothing but a white background the entire time?" after a short silence to let the viewers figure out the joke, he adds "They'd be fucking idiots".
Ask That Guy also has an earlier reference, when he straightforwardly answers a question without any twistedness.
Ask That Guy: They can't all be funny.
Also, one of this troper's favorite NC jokes. In his SNICK review, he criticizes an All That skit for assuming that, if the lines are shouted, then they must be funny:
Nostalgia Critic: Can you believe those silly writers for thinking something is funny just because you scream it? SCREAMING IN EVERY OTHER SENTENCE IS NOT! FUNNY! It is LOUD and ANNOYING. And ANYBODY WHO DOES IT SHOULD BE SHOT- *Gets shot in the head* Unshot! *Gunshot woud disappears* And given a bag of money! *Money appears in lap* ...How 'bout some lounge music? *Music plays* Yeah, that's nice.
This is a relatively common occurrence in Survival of the Fittest, both in and out of character, this exchange shows an example of (IC) lampshading.
Melina Frost:(leader of a group called the "Poison Angels") Go on then... show him why we're called the Poison Angles. [sic] Jeff Marontate:(a character facing the group) Poison Angles, huh? Oh, I'll give you a whole new set of angles in a minute, my darling.
"he spread his arms wide WOMP-CRACK!, and I really couldn't let you rush in and pull a Deus Ex, how lame would that be?" Sara glared as the boy leant against a tree, standing on a branch ten feet in the air, "This isn't some stupid story. Someone could be killed out there!"
Hat Trick as well, though one is a subversion... Genre Savvy for the win.
The Defrosters have a bunch. The fourth wall may as well not exist.
"This is the worst dialogue ever."
"Our creator knows about as much about World of Warcraft as Pixel Girl."
This parody Real Trailer, Fake Movie by the folks at Cracked.com, in which the Tropes used in every Academy Award-winning film ever (particularly those of the 80s-90s) are mercilessly lampshaded. A lot.
"Who's going to be interested in a female character who's pretty shamelessly a knock-off of her already male counterpart? ...heh." (pouting)
In Tasakeru, two characters, a Paladin Grand Mistress and her daughter, both use BFS' with Implausable Fencing Powers. It's stated that they're just that good and never mentioned again.
