In All-Star Superman, Clark Kent is interviewing Lex Luthor in prison when the Parasite escapes and attacks him to drain his powers, which have become supercharged due to extra exposure to the sun. Parasite is clearly draining the energy from something, since he is growing in size, and he keeps shouting about the strength and power he is sensing, explicitly comparing it to the sun, but Luthor never realizes that he himself is not the target. Even after Parasite has been defeated, by a fortunate earthquake that happened to save Clark Kent just in time, Luthor rants and beats his unconscious body, explaining that this is the penalty for daring to challenge Luthor.
The majority of scenarios and problems caused by the cast in American Dad! also usually revolve around this trope. Roger is almost this trope at its most intensified. He will walk over, victimize or outright kill for the most minor indulgences or offenses on his behalf (it is possible he has this attitude towards humanity due to being a parody of The Grays however). In one episode everyone gets sick of Roger being a self-centered asshole and calls him on it, so he completely changes his ways and becomes self-sacrificing and friendly—and nearly dies as a result. As it turns out, if his species doesn't express their metaphorical bile, it becomes literal bile that builds up and poisons them. One wonders exactly how they managed to work together long enough to found advanced mathematics, let alone the space program that put Roger on Earth. In another episode, he's so fixated on getting the birthday party he wants that he tells Stan and Francine to forget about their own son (who's been aged up to an old man and doesn't want to go back) so they can work on the party.
Penelope Lang from Atomic Betty. In an alternate future where Maximus had conquered Earth and Betty's identity was known to the people, making her a hero and motivation to the rebels, Penelope STILL stubbornly holds on to this trope, denouncing Betty as a "loser" like always, not taking part in any of the rebels' plans, yet still demanding their attention and protection.
Azula. When things start to fall apart she goes nuts. She does have some desire to prove herself to Ozai although Ozai couldn't care less. Though it is implied that part of the reason she goes nuts is that she realized her friends actually meant something to her, and cannot deal with the realization that their betrayal indicates that she was unworthy of their trust.
Zuko after his banishment was obsessed with capturing the Avatar to restore his honor, so much so that he helps Aang escape from Zhao even though he's an enemy of the Fire Nation. Zhao himself (who is also incredibly self-centered) calls Zuko out on putting himself before his nation; hypocritical, but Jerkass Has a Point. The sad thing is that Zuko genuinely cared about the Fire Nation before his banishment and that love for his people (and probably a wish to prove his worth to his father) is what got him into trouble in the first place. Even sadder is the possibility that Zuko still cares genuinely about the Fire Nation after being banished, in the sense that he did not wish Fire Lord Azula on them.
Although Kuzco of The Emperor's New Groove and later -School isn't a villain, it's definitely all about him. A lesson he learns and forgets in every episode. How bad is his narcissism? The opening theme for The Emperor's New School involve him claiming the trope title twice (once he had nameless guards #4, #7, #13 and #57 sing "EXACTLY" after he said it, and the other was because the lyrics mentioned his friends), and his name being spelled out twice. Once just because he liked it so much the first time. At least he had learned his lesson by the time of Kronk's New Groove, at which point he's downright selfless.
Yzma was also shown to be this when a magic situation occurs where she is Empress. Also, she was the one who raised Kuzco (his parents possibly killed by her).
Most of the characters in Family Guy fall into this trope at one point or another, especially in the later seasons.
Due to her being the Butt Monkey and Woobie, Meg rarely has this anymore. And when she does, it's entirely justified. In earlier episodes, prior to overly sadistic reinventions of the rest of the cast, Meg acted as a much less provoked Bratty Teenage Daughter however.
Meg: I can't believe you would put your family before your own daughter!
Tom Tucker displays the trope in spades. His home is filled with pictures of himself, he carried a huge poster of himself to hang up on the wall when he went to the mansion with the others, and nearly all of his conversations are about him.
Bender from Futurama is like this, frequently singing songs with "Bender is great" in the lyrics and forcing Egyptian slaves to build a colossal statue of him that says "remember me!" repeatedly. In case you don't know who the robot's talking about when he (repeatedly) invokes this trope, he always ends his this-trope-invoking statements with "...me, Bender."
Pete on Goof Troop. He is motivated so entirely by self-interest he has no qualms with taking advantage of or manipulating others (including his own son) for his own gain, no matter how unhappy it makes them or how many additional problems it causes for them. When bad things happen to him, he tends to blame other people or an unfair fate even if it's his own fault and when he deserves it. He also frequently compliments himself.
Gorillaz bassist Murdoc Niccals. The song "Murdoc Is God" should be a sufficient warning sign.
House of Mouse, as well as the Mickey MouseWorks shorts used in its episodes, depict Daisy Duck as obsessed with herself. The House segments have her frequently sing famous Disney songs rewritten to be about her and the MouseWorks shorts depict her as never noticing or caring when her actions cause trouble for her friends.
Peggy Hill of King of the Hill is a huge egomaniac who thinks she's right about everything (especially things she has very little knowledge of), thinks she can do no wrong, and if she's involved in something she will often completely take over it, often takes credit for others ideas, and will state known facts as her personal opinions (example: "In my opinion, kindling is the best wood to start a fire with"). In "The Incredible Hank", due to everyone at Strickland getting sick, Hank has taken over their workload making him feel tired and sluggish, so when Peggy asks him to help with the "Running with the Bulls" program he turns her down. Her response to this is to drug him with testosterone.
Prince Blueblood. When Rarity does meet up with him, he turns out to be a total pain. He doesn't think about anyone besides his own self, and he's frequently rude to Rarity. When Rarity finally snaps, she tells it right to his face.
At her worst in the early seasons, Rainbow Dash herself could be this. She's so egotistical that she has posters and statues of herself in her house to remind herself of how awesome she is. Though she's a lot better than many of these examples. She's considerably less self centered in later seasons, but even so.
Based on the menu and decor of the high-end restaurants in Canterlot, Zesty Gourmand takes this Up to Eleven. In order to earn her (maximum) three-hoof rating, an eatery has to cater to her tastes and her tastes alone. The more bland, the better.
King Julien from The Penguins of Madagascar. "...which is not very interesting to me because it is not about me. You see how that works?"
This also carries over to All Hail King Julien, the Prequel series. In one episode, Julien is upset over a 99% approval rating, because that means that one lemur in his kingdom does not like him.
Bobbi Fabulous. Lampshaded in his "I Am" Song, predictably titled "Fabulous" in which one of the lines is "It's all about me!" Ironically, the song was started by Phineas to convince him that his former band mates needed him for a concert. "It's all about you" comes before "It's all about me." Over the course of the song he grudgingly acknowledges the flattery until he admits that, yes, it is all about him.
Candace tends to fall into this a lot. She'll ditch friends and family alike to spend time with Jeremy, and she'll drop anything for yet another chance at her ill-advised and arguably spiteful self-appointed mission of busting her brothers. Even with that aside the beginning of "Candace's Big Day", when she criticizes her aunt's marriage plans because they didn't involve her, take the cake. Even her own mother nearly called her out on that one.
Candace: What about my needs?
Randall and Ashley A. in Recess both display this trope.
Otto Rocket from Rocket Power might as well should be the reigning champ of this trope. When it comes to extreme sports, he always wants to be the center of attention and refuses to take a back seat for once. Seriously, he would do anything to give the fans his autograph.
Angelica from Rugrats. Demonstrated when she calls a daytime talk-show host to explain that she's worried about a new sibling and throws the phone in the garbage when he explains the world doesn't revolve around her. Justified in that she's a toddler.
Homer Simpson started out as a bumbling but loving dad who regularly made sacrifices for the good of his family, but has been flanderized into an intensely selfish man who treats his family as an afterthought—when he thinks of them at all. This is demonstrated in "'Tis the Fifteenth Season", when he spends his family's entire Christmas budget on a gift for himself.
If Bart is an Attention Whore, Lisa Simpson is very much this trope, and it can be considered the underlying cause of all her other problems (Granola Girl, Soap Box Sadie, Know-Nothing Know-It-All). Lisa seems to define herself by being better then others to the point where she has a surprising lack of empathy for anybody who proves to be better then her. She once admitted she only plays the sax to make herself look better to other people. One of the numerous Recycled Scripts from the series is someone proving to be better then Lisa or having something she wants only for Lisa to attempt to destroy them. And while Lisa does usually feel guilty about her actions, it's only after her adversary has been destroyed.
This is best shown in Lisa’s repeated use of Honor Before Reason even when it is to everyone’s advantage Lisa will refuse to lie and tell the truth (usually in an overly dramatic fashion) because it makes her feel better about herself.
It appears she get this from her mother. Even in the earlier episodes it was quickly established that Marge’s Moral Guardians are more about what she doesn’t want while forcing her views on everyone else. Also anytime someone in her family chooses a new political point or religion outside of her own even if it’s more beneficial to them or even society as a whole Marge will stop at go to great lengths to prevent this. Later episodes have her being more self centered such as in “Sleeping With the Enemy” where she focus all her attention on Nelson while ignoring the fact that Lisa is developing a severe eating disorder and Nelson is openly bullying Bart in front of her simply because he makes her feel appreciated.
Brainy Smurf best exemplifies this trope in The Smurfs episode "Brainy's Smarty Party" where he throws a party that's all about him.
Eric Cartman. For example, the Imaginationland episodes had him not caring about the possible destruction of all imagination by evil characters or by the US government's nuke. Instead, he just cared about proving that he won a stupid bet so that Kyle would have to suck his balls.
Earlier than that, the episode "Cartmanland" had him spending his entire inheritance money so he can buy a popular theme park in order to have it all to himself. It becomes clear early on that Cartman is so self-centered, he will never tire of it. It is then shown that, in order to keep the theme park running, he has pay for its upkeep, and he must do so by selling tickets and thus sharing the park with thousands of other people every day. Upon this discovery, he sells the park back to its original owner, as it could not be all about him.
Cartman's self-centeredness is so strong that the realization that the world doesn't revolve around him (in "Tsst") causes him physical pain.
Satan in the episode "Hell on Earth 2006". The main plot is about him trying to host the perfect Halloween party. He wants a Ferrari cake to be wheeled into the room at midnight, but the Three Murderers accidentally smash the cake when they pick it up from the shop. Because they murdered all the bakers in the shop, they have to bake a new cake themselves, but they make it a different car model so they can bring it back in time. When they finally get back with the new cake, Satan is disappointed that it's not a Ferrari. When his minion says the guests are still happy, Satan screams, "It's not about the guests! IT'S ALL ABOUT ME!" This prompts a My God, What Have I Done?, when he realizes he's acting like those spoiled 16 year old girls in those reality shows like "My Super Sweet Sixteen" that the episode was parodying.
The show's portrayal of various celebrities often casts them like this, especially ones that are outspoken about politics. They're portrayed as not just instinctively assuming they're more knowledgeable about the subject than anyone else, but ultimately just more concerned about their own publicity than whatever issue they won't shut up about.
Their portrayal of Kanye West in "Fish Sticks" takes the cake. He doesn't get the fish sticks joke, and since he can't comprehend anything not being about him, he assumes it's a personal attack and everyone is just calling him a gay fish. He eventually comes to the conclusion that he must really be a gay fish and everyone was only trying to help him realize it.
The Warden from Superjail!, the Psychopathic Manchild in charge of his own colossal prison where he can torture its billions of inmates to indulge in his own bizarre fantasies. Was willing to throw a Littlest Cancer Patient into the incinerator because her youth reminded him of his old age, once monitored everyone's dreams (including his loyal subordinates) with his Dream Machine out of fear of a prison riot (which happens anyway), and in an alternate future declared global war on the earth and enslave all its people to make his jail into a large franchise. Even the SuperJail! Wikipedia page for his personality synopsis doesn't hesitate to point out that the Warden has committed all of Hotchkiss' seven deadly sins of narcissism and has exhibited many, if not all, the traits related to it.
In Superman: The Animated Series, Brainiac sabotages even the possibility of a planetary evacuation of Krypton because coordinating it might imperil his own escape, which he judges to be more important than the lives of everyone else on the planet put together. He even tries to prevent Jor-El from saving his only son, either just For the Evulz or because, as he explains to Superman in a later episode, knowledge (in this case, of Krypton) is more valuable if only he possesses it.
Teen Titans: In "Titans East Part 2" Robin accuses Cyborg of being this and Robin does likewise.
Donnie has shades of this in Teenage Mutant Ninja Turtles (2012) when it comes to April. He's more interested in getting April to like him rather than helping other people, especially his own brothers. If they were to die because he pursued April, he may actually regret his selfish quality.
Starscream, from , in every incarnation, in every timeline. His Moral Myopia is so acute that despite being the Trope Namer of treachery, he has blown up in fury at anyone else's attempts at betraying, nay, even insulting Megatron. Starscream's objections to people attacking Megatron are perhaps closer to The Only One Allowed to Defeat You. Still fits the trope every time he, himself, is betrayed.
Energon Starscream doesn't have this trait at all, then again his links to the character were mostly created by the English dub (in the Super Link original edit he is "Nightscream" and linked to the character merely by appearance).
Even more so is Megatron, in most continuities his primary rule in the Deceptions, is do what I say, or taste my blaster.
Qilby from Wakfu, season 2. His reason for betraying his people and his siblings, instigating a terrible war that left multiple worlds scorched to the ground and wanting to drain most magic and life from the World of Twelve? He tries to coat it in grander terms, but it still boils down to being really bored and desiring to travel the Krozmos, cost be damned. When called out on this by his victims, he accuses them of not considering his feelings.
While all four of the main characters from Xiaolin Showdown have displayed various degrees of self-centered-ness, and Raimundo even defected to the Heylin side for all of two episodes (to say nothing of the villains), the winner by far is Omi... which is why he doesn't actually get to be The Chosen One. Raimundodoes.
As Told by Ginger: Dodie Bishop, constantly. She is quick turn against her friends for popularity or if the situation suits her and acts like a complete drama queen if her friends do anything that doesn't include her, best demonstrated when she wants Ginger to cancel Darren's birthday party simply because she wasn't allowed to attend.
This is Beastly's main shtick in both Care Bears: Welcome to Care-a-Lot and Care Bears & Cousins and the main reason why he's an antagonist. He absolutely can't stand not being the center of attention and will act mean or try to ruin stuff if he feels he's not being adored and loved by everyone, or at least being paid attention to.
Thailog from Gargoyles was a clone of Goliath indoctrinated with Xanatos' profit-motivated views on life. Unfortunately, he takes that mindset further than Xanatos himself. Xanatos at least (eventually) proves that he is able to genuinely care for others. Thailog is just a wholly selfish monster.
Ollie on Wonder Pets is a good guy at heart, but is totally full of himself and absolutely must be the center of attention in the presence of company. If not, he will loudly try to draw attention back to himself.