This happens after he is convicted as Mask*DeMasque. Later, when it is revealed he is actually a murderer, he was trying to use his first conviction as an alibi, and he was actually blackmailing Ron DeLite, the real Mask*DeMasque he repeats this, only truthfully this time.
In Guild Wars: Eye of the North, the player character dismisses his ability to activate the scrying pool in the Hall of Monuments as "Just lucky, I guess." Later in the same cutscene, when the PC complains, "Why do I have to make the tough decisions?" Gwen tauntingly replies, "You're just lucky, I guess."
In a subquest of Jade Empire, you meet a woman who, in the past, watched as her boyfriend knocked another child into a river and stopped her from saving him from drowning by saying, "If we help him, he'll only tell the others what we've done. We have to let him go." You can take her to the ex-boyfriend, whom she means to kill. He offers you silver to help him; if you refuse, you echo his words.
To a lesser extent, something similar happens in The Wind Waker: Tetra has a habit of winking with one eye when she's up to something. "Up to something" usually meaning that she's helping Link in a way that ends up being not too comfortable for him, since she does not care too much about his well-being. In the end of the game, however, Tetra winks once again, before returning his sword to him, which he lost in the duel with Ganondorf. Once again, she is up to something and once again, it's not going to be a pleasant experience for Link , the difference being that she now does genuinely care about him. It's just that Tetra and Link have no other choice than to go with what they're about to do if they want to survive.
An optional one occurs in Skyward Sword: After the second temple, Link finds myself being derided by Impa for being late, as Zelda would have fallen prey to Ghirahim had she not come herself. After the third temple, when Ghirahim attacks Zelda and Impa, Link has the option to say "Am I late?" when he steps in to buy them time to escape.
Def Jam: Fight For New York is a game all about a Mob War between two gangs, one led by D-Mob (your boss) and the other by Crow, (the Big Bad) for control of New York's illegal underground no holds barred fight circuit. Less than halfway through the game the Crow says to D-Mob "Seems like you have a morale issue there, brother" when your rival walks out on D-Mob when D-Mob picks you as his best fighter instead of him. Later, when Crow's gang is so disgusted by his tactics and tired of his Manipulative Bastard shit, some of them, (including both of his dragons) walk out on him in a single cutscene. In the case of the second dragon, he walks out on Crow while in the middle of holding a gun to your head, and gives you the gun before he leaves. Guess what your character says while pointing the gun at Crow.
In World of Warcraft, "That day is not today..." is said twice at the Battle for Light's Hope Chapel, first by Flashback Alexandros Morgraine after he states that Darion will wield The Ashbringer, and then by Darion before he throws that same sword to Tirion Fordring. It's quite a spectacle.
Of course, that in turn is borrowed from a a certain someone else using a reforged sword that belonged to one of his ancestors... "It is not this day!".
In the Ulduar raid, after showing the players a vision of the Lich King, Yogg-Saron says "He will learn no King rules forever. Only death is eternal!" Then, in Icecrown Citadel, as Arthas lays dying, his father's spirit tells him "No King rules forever, my son."
In MadWorld, Jack meets with a doctor named Leo twice. The first time, Leo asks Jack to help him escape the city. Jack responds with. "I don't help people. I kill them." and continues competing in the games. The second time, Jack figures out that Leo was behind the games all along and fatally wounds him. Leo explains the whole story and points out that Jack won't be able to arrest him without helping him before he dies. Jack's response? "I don't help people... (Chainsaws Leo and watches him fall into the abyss) I kill them."
Another in the sequal, Anarchy Reigns, that also counts. Although there is confusion on how the game relates to MadWorld, but it's a clear call back. Jack is tasked by Max's daughter to bring him back. When Jack finally comes face to face, he gets ready to kill Max for the death of his daughter. Rather than cruel but slightly selfaware, or simply getting revenge, He says in a way that puts his life as killer into clear resolve: "We don't help people, we kill them!"
Tassadar: So long as you continue to be so predictable, O Queen, I need not face you at all. You are your own worst enemy.
Later, when Kerrigan doublecrosses her allies...
Kerrigan: You Protoss are all so headstrong and predictable. You are your own worst enemies. Fenix: That's ironic, I can remember Tassadar teaching you a very similar lesson on Char. Kerrigan: I took that lesson to heart, Praetor.
At the end of the UED campaign in Broodwar, Kerrigan tells Dugalle that he'd be surprised how many "special interest groups" in the sector want to see the UED stopped. In the briefing of the last mission of Kerrigan's campaign, after she has betrayed everyone else, Arcturus Mengsk contacts her to let her know he's gunning for her. When she asks him how he scrounged up three fleets to attack her, he says he made a few deals and tells her she'd be surprised how many "special interest groups" in the sector want to see her dead. Bonus points since one of the groups is the remainder of the UED fleet led by Dugalle.
In Tales of Monkey Island, at the beginning of chapter one, when Guybrush stabs LeChuck with the Cursed Cutlass of Kaflu, he yells "Unholy THIS!". LeChuck says the exact same at the end of chapter four when stabbing Guybrush to death.
In Modern Warfare 2, an Army Ranger notes that the air strike General Shepherd's just called in is danger-close in relation to where they're positioned, and another Ranger says, "Since when does Shepherd care about danger-close?" Later on, Price repeats the line when Shepherd calls in an airstrike to kill him and Soap, not danger-close but right on top of his own men.
There's also another. In the beginning, Shepherd makes a monologue, including the famous phrase "History is written by the victors". As Price and Soap are preparing to kill him, Price says the following line.
Price: History is written by the victors. History is filled with liars.
Half-Life 2: Episode One features a long speech from Dr. Kleiner in which, at one point, he lets those who have safely evacuated City 17 know that "For those so inclined, now would be an excellent time for procreation." This line is repeated as a voiceover in the opening recap in Episode Two, out of context, against a backdrop of citizens still fighting for their lives.
Knights of the Old Republic: The Jedi Exile sides with Revan using the catchphrase "Apathy is death", referring to the indecision of the Jedi Council to go to war. Near the end of the second game, she has a vision in which she has to decide which way to decide in a fight between her allies. If she tries to remain neutral, they will turn on her with mocking cries of "Apathy is death!"
In a short-term sense, Matriarch Aethyta, Liara's "father", tells a Shepard who romanced Liara that if s/he were still in Cerberus, s/he would not get within a light year of Liara, because "nobody messes with my girl." When she says that the Matriachs might order a hit on Liara if she were not watching, Shepard can use a Renegade interrupt in which s/he says s/he refuses to allow this to happen, because "nobody messes with my girl."
The memetic "Shepard. Wrex." exchange enactable in Mass Effect 1 between Shepard and Wrex gets one in 3if you sabotage the genophage cure when Wrex is the krogan leader. Those are the first words spoken in a scene in which Wrex calls Shepard out on his/her betrayal and which invariably results in his (Wrex's) death. They even get reversed to "Wrex. Shepard."
The Illusive Man brings up "our brief existence" twice. First in Mass Effect 2, referring to the threat of the Reapers, then again in Mass Effect 3, this time arguing against their destruction. Set to the same theme tune and in the same room for added points.
In Mass Effect 3 Shepard can throw one out to the quarian fleet when he/she is trying convince them to end their war with the geth.
Shepard: "The geth don't want to fight you! If you believe that for just one minute, this war will be over! You have a choice. Please. Keelah se'lai."
In the Leviathan DLC for the third game, when Shepard notices a small part of Sovereign's wreckage in Dr Bryson's lab.
In The Lost Crown, Nigel says "Nothing ventured..." to himself before stepping into unlit rooms or other potentially dangerous locales. Lucy later says the exact same thing to Nigel when he hesitates to accompany her on a risky endeavor.
The Butcher's lines in Psychonauts. "Don't run, or else Daddy's gonna kill ya!" The Butcher shares most of his mid-battle dialogue with Little Oly, from the Escort Mission earlier in the Meat Circus. These are mostly innocuous lines like "Bun, bun, bun!" and "Here little bunny!" but, as was noted above, there is "Don't run or Daddy's gonna kill you!"
Also, "When are you going to just shut up and kiss me?"
In Iji, Asha's logbook challenging Iji is entitled "To the Death." A later logbook ends with the same words, this time predicting the ultimate result of his weakness.
In Supreme Commander 2's UEF campaign, Commander Dominic Maddox mutinies after learning that his commanding officer, Colonel Rodgers, has ordered an attack on New Cathedral where Maddox's wife and son are. When Maddox tries to reason with Commander Lynch to stop her attack on the city, Rodgers tells him "Speeches will get you nowhere." At the end of the following mission, Maddox is about to blow up a huge reactor that sits right on top of Rodgers's command post:
Maddox: Colonel Rodgers, I'm feeling generous right now, so I'm going to give you one last chance to walk out of here alive. Rodgers: The UEF can survive the idiots who want to create coalitions and make treaties with our enemies, but people like you rot the soul of our great faction. I'm ready to die like a soldier, with honor. Maddox: Speeches will get you nowhere, Colonel.
Early in Sacrifice, there is the following exchange between the Lawful Good Persephone and Chaotic Evil Charnel: "Charnel, death is not the answer to everything!" "Yes. Torture also has its merits." If the player chooses to finish the campaign with the evil god, and asks the favour of dealing with another evil wizard that was scheming against him, the Ironic echo comes into play.
Charnel: As you wish. But remember, if you kill Acheron, I'll have to find a crueler demon to replace him. Player: Charnel, death is not the answer to everything. Charnel: Yes. Torture also has its merits. Player: Exactly!
There's a brief Leitmotif that plays when you kill a colossus in Shadow of the Colossus. At the end, Wander becomes a colossus, but is then struck down and absorbed by a powerful spell. As it draws him in, the "colossus killed" music plays.
As a soldier, Samus used to give her C.O. a thumbs-down (instead of the Federation's usual thumbs-up) when acknowledging a mission, just to be cheeky. Anthony gives the same gesture at the end of Other M as a sign of camaraderie.
In the 'Shade Impulse' campaign of Dissidia: Final Fantasy, the Emperor dismisses the heroes' resolution to continue fighting, by claiming that 'Insects will swarm, but they are insects nonetheless.' Later, when they actually defeat him for good, he asks disbelievingly who they are. Several of the characters have their own echoes for him, if you defeated him with them:
Firion: Just a swarm of insects. Cecil: Insects with a sting. Bartz: I heard you call us insects! Cloud: Just another bug.
In Portal 2, when Wheatley attempts to hack he says, "Let the games begin". However, once he performs a Face-Heel Turn, he says the same line after he fails to kill you, though he sounds more menacing.
Zhao: "Men never fail to underestimate women." Later when she tries to activate the hacked implant she is sure you got like everybody else: Adam: "Women never fail to underestimate men."
As the player character's journey is just beginning in Pokémon Black and White, Ghetsis gives a rousing speech about liberating Pokémon. He seems to make some good points. In the town with the final gym leader, he repeats this speech word for word. However, by this point in the game, the player has learned that Ghetsis is a far worse person than initially believed, and the whole point of the liberation of Pokémon is so he alone can control their power.
In the opening of Tomb Raider, Larson asks Lara Croft "What's a man gotta do to get that sort of attention from ya?" Since Lara Croft is obviously sexy looking, that kind of comment was inevitable. Later on, when Larson attacks Lara outside of Qualapec's Tomb and Lara defeats him, Lara retorts "Well, you have my total attention now. I'm not sure if I got yours, though. Hello?"
In Mega Man Battle Network 6, at one point Baryl tells Lan that joining the WWW was his "destiny." Lan asks him, "if this is "destiny," what about "will?" Later on, right before confronting the Big Bad, Baryl has a change of heart and performs a Heel-Face Turn and tells Lan "This is my "will.""
Later in the game, if the player joins the Dark Brotherhood, they are sent to assassinate him and get to reply;
Player: You're going to die in here!
Final Fantasy XIII: After capturing Vanille and Sazh in Nautilus, Jihl Nabaat coolly quips;
"Take care with those. For every task, there is a perfect tool"
Much later, Galenth Dysley (after killing her, and every other human in the room) has this exchange;
Snow: Dysley, you monster! People aren't yours to use!
Dysley: What else does one do with tools?
The rabbit Marquis de Hoto from The Night Of The Rabbit has the catchphrase "Nothing is impossible" which normaly is used to motivate the hero. However the real (and evil) Marquis de Hoto also uses this phrase, but as a response to the statement that it is not possible for him to escape his imprisonment.
When dealing with the Brotherhood of Stilwater in Saints Row 2, a mission starts with Jessica, the girlfriend of Maero (the Brotherhood's leader) says "Do me a favor. When you're scraping your buddy's face off the pavement, just remember Maero gave you a chance to be his partner." The next mission ends with you tossing the keys to a car that Maero just crushed with his monster truck (and Jessica along with it), and saying to him "Do me a favor. When you check the trunk, just remember you should've offered me better than 20 percent."