* Like many fics, ''[[http://summerlightning.tumblr.com/post/12939130485/ Tower, Tower]]'' pairs Princess Bubblegum (candy person) with Marceline (half-demon vampire), but adds a twist at the very end when [[spoiler:Bubblegum becomes [[CuteGhostGirl a ghost]].]]

* There's absurd amounts of fanfiction that pairs together Alice and the Chesire Cat, on the basis that he's the only character always supporting her. It's still creepy.

* From [[http://sonamyfan362.deviantart.com/gallery/41694107 this gallery page]], A New Life Era and Moe and BIOS birthday party heavily speculate this between [[spoiler:between Amy Jr. and Moe. The Recovery Part 2 shows there MIGHT be some romantic love between the two. However, they're both very young, and may not be each other's soul mates. For all we know, Bertha might be Moe's soul mate, although The Hacker probably wouldn't be too happy about that.]]

* Most romance fics involving [[GreenSkinnedSpaceBabe Mira]], including ''Fanfic/{{One Hundred Days|BuzzLightyear}}'' (what might well be the TropeCodifier) and ''Fanfic/ForGood''.

* ''Fanfic/CalvinAndHobbesTheSeries'': Hobbes thinks Maria isn't bad looking.

* While the series itself doesn't go much beyond some swooning and flirting as far as the Rangers themselves are concerned (except for Monterey Jack who [[RunawayBride used to be]] engaged to another mouse), FanFiction does, and a lot, even those avoiding flat-out {{Shipping}} fics. It usually builds on ships already hinted at in the show. The most common InterspeciesRomance is between Dale (chipmunk) and [[EnsembleDarkhorse Foxglove]] (bat).
* Also quite frequent is the "Pro" one between Chip (chipmunk) and Gadget (mouse). "Pro" fanfics are more common than "Anti" ones which ship Gadget with someone else or have her prefer celibacy to a relationship with Chip.
** While Dale and Foxglove can be seen as a couple at the end of "Good Times, Bat Times" already, Chip and Gadget usually don't start out in a relationship at the beginning of a fanfic or a new FanVerse. Fics and even 'verses like the idea of letting the actual romance grow by itself (for example ''[[Fanfic/ChipNoirDalesRescueRangers Fly to the Light]]'') or leaving one or both heartbroken because they CannotSpitItOut and putting one or both through the wringer before their deserved FirstKiss (for example ''Fanfic/RhymeAndReason'', ''Fanfic/OfMiceAndMayhem'', half the ''[[Fanfic/TheMidnightverse Midnightverse]]'').
** ''Fanfic/OfMiceAndMayhem'' is a special case. Chip and Gadget are strongly in love with each other, and they do come closer, but only as close friends because neither wants to take the next step due to genetical incompatibility. Especially Chip thinks that Gadget might want to have children one day, and that she'd better wait for a mouse guy. Later in the story, while Chip is still in Washington and the national mascot, Gadget performs a DNA check on herself on the background of the events of "A Fly in the Ointment" when she switched bodies but not heads with Dale, and she discovers that there is still enough chipmunk DNA left in her to make her compatible with chipmunks. Dale and Foxglove, on the other hand, simply don't care, or they don't want kids.
* Next to Dale & Foxglove and Chip & Gadget, ''Fanfic/TheMidnightverse'' hints at something growing between Sparky (rat) and Lahwhinie[=/=][[MyNaymeIs LaWahini]] (mouse). ''Diamonds In The Desert'' reintroduces Clarice from the ''WesternAnimation/ChipNDale'' cartoon "Two Chips and a Miss" who plays with the two 'munks, but who also is the crush of a mouse. It also introduces a third rat who looks a lot like Rat Capone and Francis (they're brothers in this 'verse), and who hits on Gadget a lot.
* It is said that ''Fanfic/TheUntoldRangerTales'' haven't left out a single possible straight pairing among their characters yet, and they're as multi-species as ''CDRR'' fanfics come.

* In ''FanFic/AradsStardust'', it's fairly common in Equestria, in part because there are an average of 3 stallions to every 7 mares. Upon hearing this, [[ShipperOnDeck Lana]] immediately figures the best way get Twilight off the fact that she's [[VideoGame/XCOMEnemyUnknown [=XCOM's=] newest test subject]] is to imply that Matt thinks Twilight is cute. Twilight takes it very seriously, and even searches for information about "Human Courting Protocols." Matt is mostly upset how Lana refuses to stop teasing him about it, but there is some ShipTease between the two.
* In the MegaCrossover ''FanFic/PeaceAndIsolation'', [[WesternAnimation/MyLittlePonyFriendshipIsMagic Luna]] has a crush on Adam, AKA [[TabletopGame/{{Warhammer40000}} the God Emperor of Man]]. It may not be completely one-sided.
* ''WebVideo/TheReviewTeam:'' [[WesternAnimation/MyLittlePonyFriendshipIsMagic Fluttershy (a Pegasus) and Basil (a dragon).]]
** Also, as mentioned in Megatron's Bio, [[WesternAnimation/DuckDodgers Queen Ty'rannee]] has a distant relationship with FREAKING [[WesternAnimation/TransformersPrime MEGATRON]] OF ALL PEOPLE. Well, how about that!
** There is hinted to be some ShipTease between Z-Squared (a meta-human) and [[WesternAnimation/AdventureTime Marceline (a vampire).]]
** [[Franchise/{{Godzilla}} Godzilla and Mothra]] are hinted to become a pairing.
* The ''[[Series/BuffyTheVampireSlayer Buffyverse]]'' and ''Franchise/HarryPotter'' CrossOver ''[[https://www.fanfiction.net/s/2547336/1/The-Savior-and-the-Scourge The Savior and the Scourge]]'' has the main pairing of Spike (vampire) and Harry Potter (human wizard) as well as the [[BetaCouple Beta Couples]] of [[spoiler: Angel (vampire) and Draco (human wizard), Illyria (Demon Goddess/ EldritchAbomination) and Neville (human wizard), and a threesome of Willow (human witch), Lupin, and Oz (werewolves).]]
* Hinted at in ''FanFic/StargateEquestria'' between Daniel Jackson and Twilight Sparkle. Leads to the following exchange with O'Neill (which he quite understandably finds rather [[{{Squick}} unsettling]]):
--> "If both participants are sapient beings, is it really besti —"
--> "Do not finish that sentence, Jackson."
* In ''FanFic/TimeLordsAndTerror'' the Doctor ([[ChickMagnet of course]]) has ShipTease with most of the main six, much of it with Twilight, and Celestia implies Luna develops a crush on him in the [[TimeTravelTenseTrouble future/past]]. He looks like a pony here, but he [[HumanAliens looked like a human]] in his original universe despite being very much not.
** In ''Fanfic/MinesOfDragonMountain'', two Diamond Dogs joke with [[CuteWitch Twilight Sparkle]] about how they wouldn't mind engaging in [[UnusualEuphemism 'Equestrianism']] with her friends [[TheFashionista Rarity]] and [[ShrinkingViolet Fluttershy]]. Unfortunately for them this is just after the BigBad has ponynapped her friends, and Twilight doesn't take it well. [[CurbStompBattle At all]].
* ''WebAnimation/TurnaboutStorm's'' RecursiveFanfiction[=/=]Unofficial {{Novelization}} of the original video series adds this as something of a subplot. For example, some attraction grows both ways between [[Franchise/AceAttorney Phoenix]] and [[WesternAnimation/MyLittlePonyFriendshipIsMagic some of the pony folk]] like Twilight and Fluttershy, and {{Original Character}}s Cruise Control (male pegasus) and Lenora (female griffon) get some ShipTease. According to the RecursiveFanfiction's author, he added those subplots inspired by subtext present in the original series.
* ''[[https://www.fanfiction.net/s/6731833/1/Angels-of-the-Storm Angels of the Storm]]'' a ''Franchise/MassEffect''/''[[TabletopGame/{{Warhammer40000}} Warhammer 40k]]'' crossover, has an eventual hook-up between [[GreenSkinnedSpaceBabe Samara]] and [[SuperSoldier Captain]] [[SpaceMarine Malleus]].
* Subverted in ''Fanfic/AHollowInEquestria'' with Ulquiorra stating outright that the very notion of such a relationship is repulsive and physically nauseating to even consider.
* The ''Series/BuffyTheVampireSlayer'' / ''ComicBook/PowerGirl'' crossover ''FanFic/OriginStory'' features Alexandra Harris, a Kryptonian, falling in love with Louise Fulford, a human being. They even talk about becoming parents one day.
* ''Fanfic/TalesOfBleachUnrealSociety'' has Raine and [[spoiler:Byakuya]].

[[AC: ''Manga/DeathNote'']]
* Any Human x {{Shinigami}} pairing. One of them, Rem/Misa, is actually canon (though one-sided).
* Many Light/Ryuk fics, thanks to heaps of in-series NoYay.
** In the ([[MissingEpisode since deleted]]) fic ''[[FanFic/SevenMinutesInHell 7 Minutes In Hell]]'', [[TheBeard Misa]] tries to force Light to put out for her and forces Light (and Ryuk) to play [[TenMinutesInTheCloset 7 Minutes In Heaven]]. But its Light and Ryuk [[ComedicSociopathy who end up getting shoved into the dark closet together]] where they discover they ''really'' [[ClosetKey like it]] and [[CoitusEnsues end up together]], leaving Misa heartbroken.
** In ''FanFic/ACharmedLife'' Light determines he needs to be closer to Ryuk to avoid the Shinigami getting bored and killing him. He becomes closer to Ryuk than anticipated when he discovers Ryuk has a crush on him.
** ''[[http://archiveofourown.org/works/861530 Dirty Entertainment]]'' where Ryuk fantasizes about using Light in other ways.
** ''[[https://www.fanfiction.net/s/4738898/1/ Everyone Deserves A Christmas Gift]]'' is an established relationship Ryuk/Light fic (though it mentions that Ryuk shapeshifts into a {{Bishonen}} humanoid form when they're together.) Light gets Ryuk a Christmas present and in return [[spoiler:[[DisproportionateReward Ryuk grants him Godhood.]]]]
** In ''Fanfic/ForbiddenFruit'' [[TheVamp Light]] seduces Ryuk.
** ''[[http://archiveofourown.org/works/153314/chapters/220084 Joined]]'', a Light/Ryuk fic where Ryuk can assume a {{Bishonen}} humanoid form [[{{Narcissist}} that resembles a dark-haired Light]] and in this form he successfully seduces Light into having a bit of fun with him.
** In ''[[https://www.fanfiction.net/s/3941333/1/ Legally Damned]]'' Light agrees to become Ryuk's boyfriend and [[IChooseToStay eventually a Shinigami and moves with him to the Shinigami realm]] in order to get away from L and the police.
** In ''[[http://archiveofourown.org/works/427645/chapters/719500 The Shinigami Wing Deal]]'' Ryuk makes Light his SexSlave.
** In ''[[http://archiveofourown.org/works/616971/chapters/1112940 To Feel Alive]]'' Ryuk is [[InLoveWithYourCarnage in love with Light's carnage]] and is a bit of a {{Yandere}} for him as well.
** In ''[[https://www.fanfiction.net/s/9596737/1/The-Unwritten-Rule The Unwritten Rule]]'' Light offers to have sex with Ryuk [[SexForServices in exchange]] for the Shinigami eyes.
** In ''[[https://www.fanfiction.net/s/4024213/1/ What Were You Thinking?]]'' Ryuk and Light resolve their sexual tension.
* ''FanFic/{{Addiction}}'' is an [[AlternateUniverseFic AU]] Light/L fic where Light becomes a Shinigami.
* In ''FanFic/BetterShinigami'' Rem is in love with Misa and [[TheVamp Misa exploits this]]--flirting with Rem in an attempt to get [[LoveMartyr Rem to kill herself.]]
* In ''[[http://atlantagirl.deviantart.com/art/A-Day-With-a-Loving-Shinigami-361953640 A Day With A Loving Shinigami]]'' Rem and Misa go out on a date.

* Happened in ''FanFic/TheTaintedGrimoire''. [[spoiler:Kanin]] is the result of one of these.

* There's the Goliath/Elisa ship which is canon. There's also Demona/ [=MacBeth=] which is semi-canon ([[WhoWantsToLiveForever they're both immortal together]] and at one point they do get married.)

* Remus (werewolf wizard)/Tonks (human metamorphagus witch) and Remus (werewolf wizard)/Sirius (animagus wizard) pairings.
* ''Fanfic/{{Deserving}}'' has Crabbe shagging a house-elf, thankfully off-screen.

* The fanfic writer superstarultra is believed to be the first person on FanFictionDotNet, and possibly the first person period, to pair Fujiwara and Kuyou together in UnholyMatrimony. (For those unfamiliar with the series, Fujiwara is a human and Kuyou is a HumanoidAbomination. Yeah, superstarultra is [[CrackFic that kind of writer]].) Since he created the pairing, it has become something of a RunningGag in ''FanFic/YouGotHaruhiRolled'', several chapters of which have Kuyou behaving as an AbhorrentAdmirer to Fujiwara. Aside from this, one arc which was explicitly an AlternateUniverse had the Anti-SOS Brigade as members of the British Royal Navy; as [[SubvertedTrope both are human]] in this arc, Fujiwara reciprocates. [[DoubleSubversion Only for Kuyou to be transformed into a kraken before the story starts.]] (Fujiwara ''still'' reciprocates.)

* There are countless fanfics like this, mostly between Hiccup and Toothless. [[MST3KMantra Don't think about it too hard.]]

* Zim and Dib (Irken/human) are by an enormous margin the most popular pairing in fanfiction, due to perceived FoeYay. Less popular variations include Dib and Tak (human/Irken), and Gaz and GIR (human/robot, though granted he ''did'' show signs of having a crush on her).

[[AC: ''ComicBook/LenoreTheCuteLittleDeadGirl'']]
* Lenore/Ragamuffin have both versions, of human/vampire, with an alive Lenore in an {{Alternate Universe|Fic}}, and zombie/vampire, with the original version of Lenore.

[[AC: ''Franchise/MarvelCinematicUniverse'']]
* ''[[http://archiveofourown.org/works/315889/chapters/507386?view_adult=true Off the Record]]'' has Loki ([[spoiler: Jotun]]) and Tony Stark (human).

* The ''Fanfic/{{Uplifted}}'' trilogy has Joachim Hoch and Hanala Jarva vas Devoas, an SS officer and Quarian Captain, and the affair between [[spoiler:Erwin Rommel and Admiral Utala Falan]].
* Interspecies Romance is the norm in ''Mass Effect'', so the fanfic ''[[Fanfic/GhostghostIknowyoulivewithinme Ghost, Ghost, I Know You Live Within Me]]'' brought this UpToEleven by having Turian/Human ''ghost''.

* In ''Fanfic/AngelasPetMonster'' Randall falls for Lucille, a saluki. [[spoiler:They even [[HotSkittyOnWailordAction have puppies]].]]

* The fandom is filled with ''tons'' of human/pony romance stories, many of them the [[TrappedInTVLand "human male from the real world enters Equestria]], falls in love with a main character" variety, if not an outright SelfInsertFic. A common joke about the fandom is that they're all into [[BestialityIsDepraved bestiality]].
** They're so common ''[[http://www.fimfiction.net/story/86723/a-night-with-lyra A Night With Lyra]]'' was able to successfully [[spoiler:MetaTwist the reader by having this ''not'' be the case]]. Just check the comments: every single one points this out.
** Teased in ''FanFic/TheCommanderOfShepherds'' between (female) Commander Shepard and Luna. The potential pony/human squick factor is lessened by Luna being a shapeshifter.
** ''[[http://www.fimfiction.net/story/100083/1/blissful-dream/blissful-dream Blissful Dream]]'' is a love story about a pony and a human.
** ''Twi and Me'' has human male and female pony (Twilight Sparkle).
** ''Fanfic/{{Xenophilia}}'' involves Rainbow Dash getting a human boyfriend. Despite being a {{Lemon}} the fic spends a fair amount of time discussing differences between humans and ponies as come to sex and gender relations. It mostly treats the human [[HumansThroughAlienEyes as the alien partner]] (talking about his ExoticEquipment, for instance).
** ''FanFic/SophisticationAndBetrayal'' involves one between the unnamed human protagonist and Rarity.
** ''FanFic/TheMixedUpLifeOfBrad'' has this between Brad the human, and Twilight the unicorn. Subverted a bit, as Brad fell in love with Twilight when she was transformed into a human, and now that she's back in her pony form he finds her physical appearance unappealing. It is noted that they cannot ever be truly happy together, being so different from each other.
** The same author's ''Fanfic/AMightyDemonSlayerGroomsSomePonies'' gives Danny (from G1 ''Franchise/MyLittlePony''), an eleven-year-old human, a crush on Surprise the pegasus (who is an adult at the time by pony standards). Nothing comes out of it, and he still has bad memories years later. It's hinted that it's all because he was still a young kid at the time, confused by his budding sexuality.
** ''[[http://www.fimfiction.net/story/170866/mating-customs-of-species-equus-parvus Mating Customs of Species Equus parvus]]'' explores this a bit: Humans have a tendency for seeking exotic partners, an evolutionary trait which used to help them reduce inbreeding by encouraging them to find partners in other communities. As a side-effect, it makes them prone to InterspeciesRomance with other sapient races--which, however, do not share this trait, so such infatuations are pretty much always one-sided (and result in the unlucky human suitor laughed off).
** ''FanFic/ArddunLleuad'' and its sequel, ''Chwe Goleadau'', has the romance between the human protagonist and Luna as one of its main themes. They have some anguish over just ''how'' far are they going to take their relationship. At the very end, [[spoiler:the point becomes moot, as the protagonist gets castrated by the villain.]]
** In ''Fanfic/AllAmericanGirl'', there are close relations between Earth and Equestria, and pony-human relationships or couples are not unheard of--the protagonist herself is a pony married to a human. That said, the setting also has temporary species-transformation magic available for the spouses, allowing such couples to actually have children together.
** ''Fanfic/AVoiceAmongTheStrangers'' has the human protagonist Jessica realising that [[spoiler:Iron Will, a minotaur]] is attracted to her, and [[DefiedTrope immediately turns him down]]. Played straight in later chapters with [[spoiler: Bastion (pegasus) and Minder (changeling).]]
** In ''Fanfic/EquestriasFirstHuman'', a socially awkward teenager falls in love with Fluttershy. [[spoiler: It is averted later on when his spirit is brought back to Equestria, he chooses to be reborn as a pony, since he could love Fluttershy more easily that way]].
** Averted in ''FanFic/TheRiseOfDarthVulcan''. Due to changeling custom and instinct, since Vulcan beat Chrysalis in a fight, she becomes enamored with, and dedicated to him. Vulcan, however, is completely disgusted with both the concept of this trope, and Chrysalis herself. So, he uses her for information and experience, but refuses all her advances.
* In ''Fanfic/SummerDaysAndEveningFlames'', Gilda (a griffin) eventually starts dating her guard captain Iron Bulwark (a pony). She's justifiably worried that dating him could make others look down on him, considering his best friend is very racist to griffins.
* [[http://www.fimfiction.net/user/kalash93 Kalash93]] wrote ''[[http://www.fimfiction.net/story/81159/1/racer-and-the-geek/predawn Racer And The Geek]]'', which makes Zecora one of the protagonist's primary love interests, if not his main one, and ''[[http://www.fimfiction.net/story/88520/1/welcome-to-the-brothel/das-laufhaus Welcome to the Brothel]]'' and ''[[http://www.fimfiction.net/story/106068/1/relax/intimacy Relax]]'', both about a pony soldier and a zebra prostitute.
** This is only a borderline example, however, as canon isn't really clear whether zebras are a separate ''species'' to unicorns, pegasi and earth ponies or just another ethnic group.
* Nearly any fanfic where Gilda, Spike or Discord are paired up with anypony, as they're the only ones of their species with any prominence (though [[MadGod Discord]] is closer to DidYouJustRomanceCthulhu).
* A pair of recurring background characters in ''FanFic/CadenceInAMinor'' are a stallion/griffon couple, who are also soldiers on the opposite side of a tense border. Despite everything stacked against them, they make a pretty cute couple, all told.
* The Blog/ReadingRainbowverse has the typical Gilda/pony romance... but mixes it up by having a cat crush on Gilda too. Not an anthropomorphic cat... a normal housecat.
* The ''FanFic/PonyPOVSeries'' has a few of these as well.
** Strife, the Draconequus of Natural Selection, is HappilyMarried to Mortis, the Alicorn of Death, and they have kids.
** [[BadFuture Dark World]]!Derpy has feelings for [[Series/DoctorWho the Doctor]], which is part of her motivation for wanting to destroy the Valeyard and force him to regenerate back into the Doctor. [[spoiler:She succeeds and ends up marrying him after [[BiggerBad Nightmare Eclipse's]] defeat, though he's using a Fob Watch.]]
** Dark World!Rarity and Dark World!Spike become an OfficialCouple and [[spoiler:become HappilyMarried after defeating Eclipse. Rarity also becomes an Alicorn.]]
** [[spoiler:Celestia and Discord]] were once in love, but [[spoiler:Discord]]'s {{Sociopath}}y and sadism ended that.
** [[spoiler:Minuette and Captive Audience]], as [[spoiler:Minuette]] is actually a Time Lord. Though it's a bit ambiguous after [[spoiler:Minuette destroys [[EnemyWithin the Master]]]] if she's still one or not.
* TD ends up in one with Cheerilee in the main continuity of ''FanFic/TheNonBronyverse''. In the alternative-continuity AU story where he gets accidentally turned into an alicorn, he eventually strikes one up with Celestia.
* Rarity and an aged-up Spike in Fanfic/TheDearSweetieBelleContinuity, as far as they know the first one in Equestria's history.
* DiscussedTrope in ''Fanfic/RomanceAndTheFateOfEquestria''. Iron Will tries to take his friendship with Fluttershy to the next level; Fluttershy politely declines and later consults her friends as to their thoughts about interspecies dating. When they all view it as a non-issue, this leads Fluttershy to think she's [[FantasticRacism bigoted for only being attracted to ponies]]. When it's further explained that this is because she wants to have children, Rainbow Dash labels her a "breeder", and assures her that it's perfectly normal.

* A [[http://anime.adultfanfiction.net/story.php?no=600041040 fanfic]] pairing an AuthorAvatar and his Gardevoir. Smut ensues.
** [[https://www.fanfiction.net/s/9931728/1/Boundless-Love-The-Tale-Of-Athena Another Gardevoir related fanfic.]] This one is about a boy growing up with a female ralt. Due to some genetics, the ralt, then kirlia comes more and more human as she spend time with the boys and as their relationships develops.
* [[LauncherOfAThousandShips Poor Ash]] has been paired with practically every character under the sun, human or Pokemon.
* [[VideoGame/PokemonBlackAndWhite N]] is often subjected to this as well, since he is [[NotGoodWithPeople closer to Pokemon than to humans]].
* Between RuleThirtyFour and Sinnoh mythology outright suggesting it, it's not surprising that Pokemon fandom is full of human/Pokemon relations.
* Author [[http://www.fanfiction.net/u/680628/WiseAbsol Wise Absol]] loves to pair Mewtwo with human women, including [[NotGoodWithPeople Sabrina]] in multiple fics, and an OriginalCharacter in ''[[http://www.fanfiction.net/s/2620103/1/Angelic-Shadows Angelic Shadows]]''.
* Subverted [[http://www.furaffinity.net/view/11568972/ here]]. It opens with a great big monologue about human and pokemon being intimate -- even having offspring -- is supposedly very common. The titular character has had two inter-species relationships: One with Tera, a pelipper, the other with Henry, a human. [[spoiler:Neither of which was intimate. Tera [[InterspeciesAdoption just wants to be a dad]], while she Henry just gets a kick out of tricking people into thinking they're a couple.]]

[[AC: RealPersonFic]]
* Very one-sided in ''Fanfic/WithStringsAttached''. Shag, a “lizardy, birdy” alien, is clearly in love with the (usually human) four, but it's strictly from a distance, and they certainly do not love her.

* Jack Frost, originally a human, is very often times paired with Bunnymund, a Pooka (a large, sentient rabbit species, possibly alien in origin), by "Jackrabbit" shippers in fan fic. Indeed most fan fics that include a romance with Bunnymund are this.

[[AC: Shin Megami Tensei]]
* It's not uncommon but [[FantasticRacism generally not held as acceptable by most societies]]. The [[HalfHumanHybrid results don't really get treated well]] to the point that a [[GuardianAngel Guardian]] [[IdiotBall suspected of being half-demon]] was [[BullyingADragon treated very coldly]] on suspicion alone. She snapped on her former allies after being treated better as a prisoner of war.

* ''Fanfic/BlizzardStorm'' features the main pairing of original character, Eric, with [[spoiler:Sakido]]. A human and a [[spoiler:demon]]
* ''Fanfic/ADifferentMedius'' has Toby's unrequited feelings towards Sam explored at length.

* A currently unfinished fanfic series which pairs up the characters of Patricia (a [[EverythingsBetterWithPlatypi platypus]]) and Peri (not known for sure, mostly assumed to be [[MixAndMatchCritters a cuttlefish/squirrel hybrid]]).

* The Kirk/Spock pairing from many a fanfiction[[note]]also the {{Trope Namer|s}} for SlashFic[[/note]]. Kirk is human, Spock is half-human, half-Vulcan.
** The fic ''[[https://www.fanfiction.net/s/9795158/1/Written-in-the-Stars Written in the Stars]]'' deserves mention in that Kirk has been genderswapped, and ends up with Spock in ''four different realities''. Each time resulting in a HalfHumanHybrid daughter.
* The pairing of Captain Picard and Q is rather popular in fanfiction. Picard is a human, and Q is a [[SufficientlyAdvancedAlien transcendent energy being]], who can shape shift at will and warp reality like it was a toy. Fans are fond of exploring not only the various differences between Q's god-like perceptions and Picard's idealistic mortal worldview, but the inherent power struggle that comes from Q's powers and Picard having to use his mind and challenge himself to try harder to stand toe to toe with Q's antics. As a hyper-intelligent and virtually omnipotent being few things manage to excite Q, so Q's fascination with Picard as a particularly special human is given a lot of focus.
* ''Fanfic/{{Bait and Switch|STO}}'' has one between a couple of {{Mauve Shirt}}s from the USS ''Bajor's'' security department, Ensign Kate [=McMillan=] (human female) and Lieutenant (JG) K'lak (Klingon male). They're stated to have been in an on-again, off-again relationship for the last couple of months, but decide to go exclusive in chapter nine.
* In ''Fanfic/RedFireRedPlanet'' Lieutenant Commander Brokosh, a Lethean mercenary, is HappilyMarried to Klingon noblewoman Ba'woV, daughter of N'Gara, of the House of Chel'toK, a Klingon. Brokosh signed with the Klingon Defense Force when their son was conceived, since Chel'toK is fairly {{impoverished|Patrician}}.
* ''Fanfic/FromBajorToTheBlack'' has Kanril Eleya, a Bajoran, date a human Starfleet Academy cadet exclusively for about a year, to the point of her starting to talk about Bajoran betrothal rituals. This ends badly when Jerrod Dalton is offered early graduation and skips town for the USS ''Planck'' in the middle of the night.
* "Fanfic/RemembranceOfTheFallen" has Tiana Lanstar visit the gravesite of her deceased wife Sobaru, a Bajoran.

* One of the fandom's two major [[OneTruePairing OTPs]] (and thus the subject of vast amounts of fanfic) is Destiel, pairing Dean (human) with Castiel (angel).

* Klein (Salamander) and Alicia (Cait Sith) have something going on after his RescueRomance during Act 1 in ''Fanfic/FairyDanceOfDeath''.

* In one 4chan copypasta fic King Arthur in a PeggySue scenario decides that he's better off in making [[AbhorrentAdmirer that squirrel]] (who actually loved him and he has Merlin change into a human form) his Queen instead of [[YourCheatingHeart Guinevere.]]

* Although the fanbase for this pairing dates back somewhat to the 4Kids series, Donatello and April O'Neil has had a wave of momentum because of Don's crush on her in the Nickelodeon series, spawning numerous fanfics and fanart, Another popular couple inspired by both 4Kids and Nick eras are Leonardo and Karai.
* Fans of [[WesternAnimation/TeenageMutantNinjaTurtles1987 the 1987 animated series]] have Donatello/Irma, April/Michelangelo, Michelangelo/Kala, and Leonardo/Lotus Blossom.

* ''[[https://www.fanfiction.net/s/4138412/1/Sound-of-Pulling-Heaven-Down Sound of Pulling Heaven Down]]'' has the OfficialCouple of Simon and Nia, except here Nia is an [[EldritchAbomination Anti-Spiral]]. In typical ''Gurren Lagann'' fashion, it barely impedes them at all.

* Fan fiction for ''Literature/TheLordOfTheRings'' likes to ship a daughter of Men with an elf or a hobbit.
** ''FanFic/AncientLanguages'' has an interspecies LoveTriangle. Elhael and Glorfindel, both male elves, want Lyla, a mortal woman.
** ''FanFic/AFarGreenCountry'' has Elden, mortal man, and Nellas, female elf, unless SheIsNotMyGirlfriend.
** ''FanFic/TimeWillTell'' has a romance between Jorryn (the woman from America) and one of the hobbits, but it takes a long time to develop.
** Some authors use a {{Metamorphosis}}, by which the daughter of Men suddenly becomes a elf or a hobbit. This is a big hint that her love interest will be another elf or hobbit, and a same-species romance will ensue.
* Many fan authors for ''Literature/TheHobbit'' have no concept of a female dwarf. Thus dwarves like Thorin, Fili and Kili are always falling in love with some elf or mortal woman. Dwarf with dwarf romances are rare. ''FanFic/WorldsApart'' has a dwarf with elf romance.

* Endemic in fanfics/doujins, with writers having access to [[LoadsAndLoadsOfCharacters a huge cast]] that represent [[LoadsAndLoadsOfRaces a vast array of creatures]]. Merely some of the most popular pairings are [[BelligerentSexualTension Marisa/Alice]] (human witch[=/=]WitchSpecies), [[DidYouJustRomanceCthulhu Reimu/Yukari]] (human[=/=]HumanoidAbomination), [[UnequalPairing Remilia/Sakuya]] ([[OurVampiresAreDifferent vampire]]/human), [[UnequalPairing Yuyuko/Youmu]] ([[CuteGhostGirl ghost]]/[[HalfHumanHybrid half-ghost]]), [[SubordinateExcuse Kaguya/Eirin]] ([[OurElvesAreBetter Lunarian]]/[[PhysicalGod Lunarian god]]), [[FoeYay Kaguya/Mokou]] ([[OurElvesAreBetter Lunarian]]/human), and so on and so forth.

* Multiple mentioned in ''Fanfic/BeautyOfTheBeast'', back in the Golden Age of Cybertron. The two important to the series are June and [[spoiler: Megatron]] and Miko and Bumblebee.

* ''FanFic/ForbidenFruitTheTempationOfEdwardCullen'', on top of the human/vampire pairings, features Jasper Cullen and a human guy he picked up in a bar having a threesome with a talking panda. Yes, you read that right.

[[AC:''TabletopGame/{{Warhammer 40000}}'']]
* ''[[http://1d4chan.org/wiki/Story:Love_Can_Bloom Love Can Bloom]]'', an unfinished fic from the /tg board at [[ImageBoards 4chan]] in which the [[SpaceElves Eldar]] Farseer Taldeer from ''VideoGame/DawnOfWar'' and a [[ColdSniper Vindicare Assassin]] named LIIVI meet on the battlefield and eventually fall in love. Later fics spun off from LCB would introduce their [[HalfHumanHybrid daughter Lofn]]. A self-admitted GuiltyPleasure by its fans, as such a thing is impossible for [[FantasticRacism innumerable]] [[ArtisticLicenseBiology reasons]]. What makes this particular fic notable is that Creator/GamesWorkshop, 40K's parent company, [[AscendedFanon dropped a couple of acknowledgements to it]] (a pic of a Vindicare watching a Farseer and a quote attributed to LIIVI) in ''TabletopGame/DarkHeresy'' sourcebooks.
** A spin-off ''[[http://1d4chan.org/wiki/Love_Can_BLAM Love Can Blam]]'' ('''NOTE''': {{NSFW}}) features an encounter between a guardsman deserter and a female [[TheGreys Tau]] medic that quickly goes from IntimateHealing right into full-blown [[CatchPhrase heresy]]. [[spoiler:As you may have already guessed from the title, [[DownerEnding it doesn't end well for them]]]].
* ''[[http://1d4chan.org/wiki/Gav_and_Bob Gav and Bob]]'' has an Ogryn named Gav fall in love with a human woman. [[spoiler:Being 40K, [[BittersweetEnding it doesn't end well]].]]

* ''[[http://www.fanfiction.net/s/4235229/1/Sirens_of_Azeroth The Sirens of Azeroth]]'' suggests that the many species of Azeroth don't have a huge amount of trouble with, at least, casual interspecies romance/intercourse, demonstrating among others a [[OurDwarvesAreAllTheSame Dwarf]]/Draenei (seven-foot faun-like blue alien) relationship, a Troll/Blood elf lesbian couple with an open relationship, and a pair of tiny gnomes talking about how their favorite types of 'men' are Tauren ([[HotSkittyOnWailordAction huge]] [[ALoadOfBull minotaurs]]), though they could just be making that up.