Spuds McKenzie: what a playah! What a dog playah! What a dog playah with human girlfriends...er...right.
The "twist ending" to a recent AirWick air-freshener commercial is that the talking elephant housewife's husband is a many-stinky-shoed centipede. In fact, many of that ad campaigns pairings are interspecies romances. Same-species romances are the minority.
If you are asking, the other ones are chimpanzee-skunk, giraffe-boar and penguin-bear. The last one's sons are pigs.
Fruit By The Foot has a commercial with a female lizard getting attracted to a young human male after mistaking the long strip of gum stretching from his mouth for a prehensile tongue.
Pretty much all of the Orangina ads, but especially the big musical number with the bear and the deer.
This ad and this ad imply that the Kia Soul hamsters find human women attractive.
There's a commercial for a Dora the Explorer mermaid Dora toy, which shows a mermaid girl whose mother is a human and father is a giant fish.
This ad for the Bank of Queensland pairs a human hunter with a deer.
Direct TV's recent ads feature a man married to a human-sized living marionette. They even have a son.