"Ghost Cop got a gun that shoots a tornado of bullets and unicorns. Sockarang got a gun that will shoot whatever you want onto you. Axe Cop got a plunger.
Later, Axe Cop takes that plunger and sticks a zombie's head onto it.
Ax-Crazy pirate queen Bangladesh Dupree is tasked with guard duty and told to kill anyone who enters the room unauthorized. She asks if she is allowed to use any weapon she wants; the list includes cheese.
That one's not to hard to figure out; you just ram the cheese down the person's throat until they choke.
Punch/Adam Clay is able to flick rivets with bullet-level velocity and with quite a degree of marksmanship.
In Girly, Winter fights with a giant dildo (yeah), and she occasionally uses her own cat as a weapon. Later, Otra will switch weapons with Winter and wield the giant dildo too.
Duv of Goblins favors a pair of small, square razor blades held between the first and second fingers of each hand. They have no handles, and she doesn't even hold them with her thumbs; she just grips the blades between her knuckles. Judging by the damage she does to her enemies with them, they're absurdly sharp, so it makes you wonder how she avoids slicing her own fingers off.
Hanna of Hanna Is Not a Boy's Name tries to face supernatural monsters with a cheap hammer and... a magic marker.
Grape Jelly of Housepets! is fond of wielding a broom as a weapon, which she first did to ward off a pair of raccoons who had broken into her kitchen. Tame enough, right? But later on in the comic it's revealed that she once did the same thing to beat the crap out of a kidnapper and his pet alligator. And he was an armed kidnapper. And she was still a kitten at the time!. Though she didn't actually do it, Grape has also threatened to suck down the end of a candy cane and shank someone with it.
Dad Egbert's weapons of choise are cakes and SHAVING CREAM.
Bro rivals Mr. Egbert up there, by using Lil' Cal in his fight against Dave. He also knows the art of "weaponizing a sylladex", by loading it with heavy items to be expelled as projectile weaponry when needed.
The STRIFE SPECIBUS is pretty much this trope, as almost anything can be used as a weapon, from crowbars to fancy santas and a stuffed plush bunny. Strife Specibi include normal stuff like Gunkind and Swordkind, as well as things like Dicekind, Canekind, and Spoonkind. Close examination of the back of John's STRIFE SPECIBUS before he sets it to Hammerkind reveals that ice skates, gloves, aerosoles, and more are all possible weapons. And presumably, all of these items can be broken, changing the specibus along with it. 1/2barbwirekind, anyone?
Xykon once killed an entire room full of elite paladins with a bouncy ball. Granted, it had a symbol of insanity on it, causing them to attack each other, but still, a freaking bouncy ball!
The prequel Start of Darkness also shows Xykon beating Fyron Pucebuckle to death with an award statuette.
Grand Piano Scythe! Bowen Stilson Dogg Bust Scythe! Teaspoon Scythe! Ugly Dog Scythe! Fancy Santa Scythe! A-BOMB SCYTHE! are just the Gambit Schema attacks for one character. The regular weapons include a key (revolver), a ring of keys (Tommy Gun), a tube of lipstick (that is also a chainsaw), a paint roller (taser), paint stripper (flamethrower), a hairpin (machine gun), a teddy bear (knife), a sextant (sniper rifle), and a typewriter (the series' Infinity Plus One Tommy Gun). Thanks to the Good Bad BugsRunning Gag, anything can be a lethal weapon.
Lots of this pops up during the battle with DMK too. Cinderblocks, stone busts, crates and barrels, candy, and even two time-traveling versions ofPickle Inspector are used as weapons. It's safe to say that MS Paint Adventures practically runs on this trope and Mundane Made Awesome.
In Questionable Content when Martin and Steve are attacked by the vigilante Vespavenger they defend themselves with what's on hand, a stop sign and a trash can lid. Lampshades JRPGs when Martin comments,"I am nowhere near effeminate or spiky haired enough for this.
The stop sign makes a reappearance, along with a broom, when Martin, Faye, and Dora confront the Vespavenger.
Dame Madeline Goodlaw from Rusty and Co. seems to have the ability to turn random farm implements into powerful magical weapons. So far, she's turned a hoe into a Holy Avenger, a shovel into a Vorpal halberd, and a pitchfork into a Trident Of Warning.
Schlock of Schlock Mercenary once used a lump of battleship plate against an enemy, fulfilling both this trope and Shield Bash (which is what said plate had been used for until then). Schlock himself is an improbable weapon.
Tailor as well, who uses his scissors as terrifyingly effective weapons. As he does have to cut through the local super-resistant clothing, he can snip off a super soldier's hand with little trouble.
In Shortpacked! we have Amber who wields a vicious pushy-popcorn-ball-popper-thingy.
Ax in Steamgear Inc appears to wield a flamethrower arm cannon as her weapon of choice... until it's revealed to be an arm-mounted fire extinguisher instead.