Murdoc: Erm, Russel, if you touch my leg one more time in this interview, Im calling the cops, OK?
The fact that Murdoc has repeatedly implied some homosexual desires, not the least of these incidents being the "DARE" video.
Word of God when asked if there was anything between 2D and Murdoc was "Highly unlikely, but use your imaginations."
Many fans have pointed out that the odd placement of the teeth marks on the love bite that 2D sports on the Demon Days cover rather heavily imply that said love bite was made by none other than Murdoc.
On the subject of 2D/Murdoc, the chloroform scene would be quite suggestive if taken out of context.
Even before the chloroform scene there's a bit of Ho Yay — Murdoc slaps 2D for speaking out of turn (or something along those lines), and his high-pitched shriek of a response sounds ridiculously pornographic, especially considering it comes from a male. Murdoc ordering him around afterward doesn't really help things, either: "Silence! I'm spinning the disks here! You just sit there and shut it until I say so!"
Murdoc had a habit of stealing or scaring away 2D's girlfriends and kidnapped him, which some claim that it's a sign of possessiveness. Plus, he called 2D 'pretty' a few times.
Murdoc recently answering a fan question about if it gets lonely on Plastic Beach with just 2D around had him responding with, "I have measures in place to alleviate said loneliness, and I won't go into great detail about that."
In Rise of the Ogre, after being told the story about how 2D fell out of a tree and had all his hair grow back blue, Murdoc asks "collars and cuffs?' to which 2D "looks down awkwardly, scratching his head." Yes, Murdoc has inquired about the color of 2D's pubic hair.