Hell Is That Noise / Resident Evil

Resident Evil 4

  • This game cranks it up a notch with the creepy, Vader-esque breathing from the Regenerators. It's a million times worse when you can't actually see them, too. Accompanied by equally creepy music.
  • The Iron Maidens, an even more nightmarish variant of the Regenerators, sound even worse.
  • The sound of a chainsaw and "Te voy a matar!"? signals one hit killer elite mooks.
  • Another one from the 4 is the dry, shuffling sound made by the Novistadors. Particularly horrific because they're essentially invisible, half the time. Not to mention the first encounter in the sewer. A very loud SPLOSH followed by an increasingly louder series of sploshes indicating footsteps.
    • The chanting of the Illuminados Zealots: "Cojelo, cojelo, cojelo, cerebros, cerebros, cerebros, morir es vivir, morir es vivir, HAHAHA!" :WHACK:
  • The deep piano chord you suddenly hear when you enter the building on the island with the regenrators. This basically indicated the most horrifying part of the game has begun.
  • The Ganados' raspy hiss or whatever when one of them lunges at you, because it's hard to escape unless you do some quick maneuvering, which can be difficult to pull off in RE4.

Resident Evil 5

  • In RE5, the distinctive pitter-patter of the lickers walking on metal catwalks (and the metal ceiling will also have you aiming your shotgun in a frantic 360.
  • There's also the horrible screech of the Reapers.
  • The sounds of the hunters. Tap, tap, tap, AYIAAAR!!! BWEER, YOU DIED.

Resident Evil 6

  • The cry of the Rasklaplanje. You know you can't kill it, and if it kills you, a chest-buster ripoff immediately ensues.