In Superior Spider-Man #2, no matter what Otto tries to do, Mary Jane grows further away from him, showing that MJ only loves Peter and can tell if he is being different. Peter as a ghost also tells Otto (who can not hear him) that Mary Jane is his soulmate.
The nicest part happens after Otto really falls in love with MJ: he realizes that it is dangerous to be with her, and stops his romantic advances. It shows that Otto can change. Especially since MJ was going to kiss him and he stopped her.
In Superior Spider-Man #4, Otto visits May and works on a design for her to be able to walk again.
In Superior Spider-Man #8, a girl with severe brain-damage was successfully treated by Otto and gives him her personal doll in exchange for a Spider-Man doll. Otto even points out how heartwarming this was.
Otto's romance with Anna Marconi is rather sweet.
Jameson defending The Lizard after he saved him, claiming he was a hero.
In the Team-Up series his reaction to Fulminata's death in issue #4 was somewhat touching, as well as helping restore the hospital's power.
Jameson keeping the feds off Max Modell, and then the man resurrecting Spider-Man after he was lost in the time explosion out of the good will Peter earned beforehand. It moves into Tearjerker when you realize that Otto has basically destroyed everything Peter worked for this arc.