During one Thanksgiving-arc strip, when Sally and Ted are spending the holiday at his old home with his family, Sally wakes up in the middle of the night to find Ted still sitting up in bed. Ted admits that sleeping in his old room has caused him to realize that, even years after his childhood, he still can't connect with his dad, his brothers still treat him like a kid, and he still doesn't know what he wants to do with his life, and then he opines that he doesn't know what, if anything, has changed for him. Sally's response to all this? To interrupt Ted's rambling with a Big Damn Kiss that extends over three panels.
Sally: I think a few things have changed for you, Ted.
That same arc has Ted finally standing up to his brothers, only to inadvertently insult one that had just gotten divorced and Ted winds up feeling bad about it. Sally points out that he'd had no idea about it and that his family has him locked in a cycle of passive aggressive guilt, not keeping him in the loop and then blaming him for not being in the loop.
Sally: You don't get to feel bad about yourself, Ted. Sorry, I'm never going to be okay with that.