Chaz' reaction to Chuckie's Big "NO!": "He said his first word! He's talking!"
Chuckie rushing to the church, ignoring all else and overcoming his fears to save his Dad. Especially touching is his desperate and determined cry of "I'm coming, Daddy!"
The scene where Coco takes Chuckie's teddy bear and his friends join in on the tug of war to try to get it back.
Tommy instinctively pulling Dil out of the way before a bowl falls on him.
Spike's interactions with Fifi. As Betty put it, "Looks like Spike found himself a little patootie!"
Lou telling his sons that while he loves Lulu (his second wife), he'll always love their mother, explaining that his love for Trixie (Stu and Drew's mom) was what ultimately helped him to find love with another.
Drew: I'm really happy for you Pop! Stu: Yeah, Lulu's a great lady. Lou: Yep, she's a keeper! 'Course, no one will ever replace your mother. (places his hand on his heart) It's her love in here that helped this old geezer love again.
Chaz giving Chuckie his teddy bear made for him by his mom; it instantly becomes his most treasured possession through his entire adventure in Paris. Even more touching is how Kira ensures it is saved when Coco tries to get rid of it.
Angelica genuinely apologizing to Chuckie for conspiring with Coco. Even she knows that was wrong.
Tommy riding on Chuckie's head wearing the helmet while the latter used the suit was pretty adorable. Their friendship knows no bounds.
When Coco pulls her dress from under the babies, causing them to fall over, Angelica becomes angry and rips her dress, exposing her underwear. Seeing Angelica defend the babies(in her own way) is very sweet.
"Listen lady! Nobody messes with my dumb babies 'cept me!"
Chuckie and Kimi talking about Melinda, Chuckie's deceased mother, at their parents' wedding.