The incredibly touching ending, where Neal takes Del home for Thanksgiving after learning that he is homeless and alone, and his wife has actually been dead for years. There's a strong hint that perhaps, after so many years of hopeless drifting, things may be about to turn around for Del.
Also, the scene in which Neal finally gets a room on the way back home, but Del does not, and appears to be forced to sleep in the burned-out wreck of a car on a winter night. Neal comes out, says to Del, "You're gonna freeze to death out there," and lets him come in to share the room. Big Awwwww moment right there.
Followed by them getting snockered on the room's various whiskey samples, in a great piece of male bonding.