- When Kuo is feeling particularly down about being a Conduit during the "Hearts and Minds Campaign" mission. Also doubles as a Crowning Moment of Funny.
Cole: Listen, Kuo, you're not a freak. You're still you. You just happen to have ice coming out of your ass.
Kuo: Wow, that's...that's really sweet, Cole. Thanks.
- After Zeke saves Cole from one of Bertrand's traps - all by himself, no less - Cole tells Zeke he's been treating him like crap and apologizes. To which Zeke replies:
Zeke: I don't call you "brother" because I like the way it sounds.
- The Action Film, Quiet Drama Scene with Cole and Zeke just sitting on a couch watching a movie. No talking about fighting killer monsters, no worrying about the Beast or the Plague, hardly any dialog at all. Just a pair of old friends pretending everything is back to normal for a few hours.
- Cole comforting Kuo even after she does a Face-Heel Turn.
Kuo: I was... I am scared.
Cole: (very softly, almost as if to himself) I am too.
- If you were on the good path in Infamous 1, there's a side mission early in Infamous 2 called "Past Decisions". Probably the easiest mission in the entire franchise, you start the mission, and a woman talks about her mom being in Empire City, and how she probably would've starved to death if it hadn't been for you. You get a kiss on the cheek, she walks away, mission accomplished. (After a little "Hey, where's MY kiss?" bitching from Zeke.) Considering how much easier being evil would've made I1 (evil route = more damaging powers), this mission alone makes the entire good path worth it.
- How about that time when Nix spats at the dead Behemoth/Bertrand and Kuo takes pity on her for that? It's so nice to see these two, who are antagonizing each other for the entirety of the game, get along for once.
- If that wasn't enough, in the good ending, Kuo, who does a Face-Heel Turn, respects Nix, who dies doing a Heel-Face Turn, by saying she made the right choice in using the RFI to kill all conduits.
- Cole's decisions in the Good Ending. After an entire game of build-up, Cole has come to terms with what it means to be true hero, and faces his death with courage knowing that saving millions of lives is worth it.
- The good ending:
Zeke: I love you, brother. And I'm sure gonna miss you.
- Oddly enough, the good ending is another Heartwarming moment for Kessler. While his methods were extreme, it is worth bearing that this was a man who ran away from The Beast to spend a few years with his family. And upon gaining time travel powers, he went back in time and was forced to murder the woman he loved so as to turn the man he used to be into the kind of person who could save the world. While there is no way to forgive him for what he did, it is rather heartwarming to realize that he would probably feel it was worth it. And from what we knew of Trish, she would likely feel the same way.