In the comic, Beatrice tells Charon she will pray for his burden to be lifted. Lucifer mocks her and claims that prayers are useless. When Charon is killed by Dante, these are his final words:
Charon: I scarcely believe it. Even here... her prayer was heard. At long last... my burden is lifted. Thank you, Lady Beatrice. For the first time... Hell has known mercy.
Every time Dante absolves someone.
Dante and Beatrice's scene at the ending of the game.
Toward the end of the game, Vergil recounts the Harrowing of Hell. It's pretty much a line-by-line recital of the proper part of the original poem, but something about his reading of it is oddly touching. Being a "virtuous pagan," and therefore unfamiliar with Christian theology, he doesn't understand exactly what happened. All he knows is, "For a moment, I perceived that the universe felt...love."
Beatrice's brother questions why the Crusaders are in hell, since their killing of Muslims was in the name of God. Dante says "Murder is only ever in the name of the murderer"; considering he was a full-fledged and very enthusiastic Crusader himself, he's clearly come a long way in terms of morality.