There are several moments hidden through the series that aren't just Hope Spots but genuine litte statements. This trope found the panel of the wolves at the end of chapter 5 to be one of the most touching panels in comic book history.
Cindy's revealed 'origin'. Characters spend the series wondering how she came to be so determined, knowledgeable and fierce about surviving and protecting herself and her son, even making up fancy backstories ('She's a green beret!'). The truth is far less cliché and a lot more thoughful.
Shaky and Sofia together watching the aurora borealis, right before the latter's suicide.