When the unsentimental hard-ass Whistler desperately cries to a dying Blade "Don't you give up on me, boy!! You didn't give up on me, and I'm not gonna give up on you!!" you know that even he is capable of love.
Nyssa's death, the only real sympathetic vampire in the series, she also makes the audience think about how pureblood vampires don't have a choice. Its obvious she and Blade have a thing, and she ends up dying. SPECTACULARLY.