Two things: a) does anyone else get a Mighty Whitey vibe from the implication that Western medicine may be the key to eradicating the Redface Pox?
And b) if they get to Shogun Ienari, how the hell are they going to do the gender flip? The real Ienari was said to have fathered 75 children, how are they going to reconcile that with a female shogun? They're either going to have to severely reduce the number of children down to the direct heirs and key players or make Ienari the first male shogun in decades. (Yes, I have been reading about the shoguns on The Other Wiki, why do you ask?)