One Bloom County strip sets up the punchline by saying that the local newspaper reported on a "heterosexual AIDS epidemic" that turned out to be a false alarm. ...Yeah.
A Calvin And Hobbes strip has Calvin criticize Susie's drawing of a home with a flower garden, instead claiming his manlier drawing of B-1 planes nuking New York. The September 11, 2001 attacks put the strip in a Dude, Not Funny! stance.
FoxTrot: A strip that was supposed to run on July 22, 2012 that involved Jason and Marcus testing a sniper squirt gun on Paige was pulled after the Aurora, Colorado movie theater shooting at the midnight premiere of The Dark Knight Rises; and was replaced with a strip intended for the following week.
