In Episode 53, Mackenzie does this to a tantruming Brittnay.
Brittnay: I. Don't give. A fuck! I want my revenge, and I want it now! Now! I want my revenge! I want my revenge! I want my revenge!
Mackenzie:(slaps Brittnay) Brittnay! Baby! Get a hold of yourself! I am sorry I had to smack you like that, but you have got to lock it up!
In Episode 76, Trisha 2 does this to an incredibly nervous Trisha C.
Trisha 2:(slaps Trisha) Yah! Hey! Get it together! You're gonna do this! You're doing it for Trishas all over the world! (they look into a mirror) Especially the one right here.
The Grossery Gang webseries parodies this. In "The Grossery Gang Movie", when Rocky is only "mildly concerned" about Stinky's cleaned-up plight, Doc Broc still treats him as hysterical and slaps him, as Rocky still reacts how he "needed that".