* The sight of Elijah Wood [[http://www.youtube.com/watch?v=3OPuUUa4e1s&feature=related laughing in a high-pitched voice]] (at about 7:20) during the drug test scene.
* Marybeth getting Stokeley to actually talk to Stan? She pushes her onto his desk, making her land right in his lap. And it works!
* The entire group erupting into panic once [[spoiler:Delilah reveals herself as an infected]], with all the guys trying to will themselves into shooting her. And then Stokely bursts through the crowd and goes "I'll [[PrecisionFStrike fuckin']] shoot her!" and fires about five bullets in [[spoiler:Delilah's]] general direction.
* While it's MoodWhiplash, when the coach [[spoiler:stabs the principal with a pencil]] he says, "I've always wanted to do that." [[spoiler:The principal]] thinks she's made it to safety, locking him inside, another teacher stabs her repeatedly with a pair of scissors, and then says, "I've always wanted to do that."
* Casey and Delilah find Mrs Bromwell's body ([[WhatHappenedToTheMouse ?]]) in the closet and come back with the police. The body has been moved and replaced with a mannequin used for life-saving practice. The principal remarks that the doll does have a strong resemblance to Mrs Bromwell.
* They kidnap the Alien!Principal and tie her up in a net. Her response? "You're all expelled"
* Zeke is trying to keep serious during the whole getting high scene. But Delilah's bitchiness makes him burst out laughing at random (which is [[MoodWhiplash less funny moments later]] when [[spoiler:it turns out that she is infected]])
--> '''Zeke:''' (''laughing'') Is she always this much fun, man?
--> '''Stan:''' Nah, sometimes she can be a ''real'' bitch.
* "Aliens are taking over the ''fuckin''' school..."
* When Casey's parents confiscate his PornStash. It's made clear that they both know exactly where it is, and his father looks slightly nostalgic as he contemplates the magazines.
* Zeke's ScrewThisImOuttaHere reaction to [[spoiler:a possessed Miss Burke's decapitated head growing tentacles and wandering back to its body]].
* Stokeley's epic putdown to Delilah?
--> "Fuck you, titbags."
* After the incident with Mr Furlong and they've realised a) aliens are possessing everyone, and b) they just killed a teacher...
--> '''Stokeley:''' Isn't this the part where someone says "let's get the fuck out of here"?
--> '''Stan:''' Let's get the fuck out of here.
* Stokeley's BigDamnKiss to Stan immediately turns into MoodWhiplash when she sees Zeke, Marybeth and [[NotSoAboveItAll even Casey]] giggling at the suddenness of it.