Derpy, angry that Snowflake took the last Lemon Muffin Surprise, tosses Twilight Sparkle all the way to Celestia's throne room after Twilight tries to calm Derpy down, and then tosses a house...which lands on top of Twilight.
This reading of a Spiritual Successor to Cupcakes. Mood Whiplash is pretty much a constant here and it has some genuine Nightmare Fuel, but the reveal it's fake and trolls a specific youtube user pushes this to CMOF territory.
Pretty much any Derpy Hooves video voiced by Youtube user BaldDumboRat, whom a lot of fans have basically embraced as her unofficially official voice. For example:
The creators of Epic Pie Time And Epic Cupcake Time give us their greatest video yet; Epic Wub Time: Musicians Of Ponyville, featuring Vinyl Scratch and Octavia! It's every bit as hilarious as it sounds.
*massive bassdrop* "GOOD MORNING PONYVILLE!!!"
Poland Can Pony, Too. This video collaboration is a hilarious collection of audio from Polish movies, songs and translations of video games, set to scenes from the series. It has English translated annotations.
TechRat: Fluttershy's animal preserve became gripped in chaos this past week as its inhabitants became locked in a bizarre civil war. It seems it all started when Fluttershy installed a new pig pen right next to her open-air aviary. The noise and stench emanating from her herd of swine apparently annoyed her normally peaceful flock of colourful birds. And these irate fowl began launching themselves at the pesky porkers in retaliation. Fluttershy attempted to protect her pigs, by hiding them behind an increasingly complex series of rickety structures. However, the birds always seemed to know exactly where to ram into the wooden planks to make them collapse, causing the pigs to be crushed to death under the fallen debris.
As bizarre as this all sounds, it gets even stranger. Ponies walking by became captivated by these bizarre attacks, and many of them started picking up birds themselves and tossing them into the structures in an attempt to knock them over. The Cutie Mark Crusaders even built a giant fricking slingshot in a field next to Fluttershy's house, and started using that to launch feathered creatures into the structures. In fact it became so popular they started selling chances to other ponies to try it out. They currently have two payment options available: 99 cents gets you unlimited tries, or you can play for free, and Sweetie Belle will stand in front of you and hold up signs for local businesses. (cue Sweetie holding up a sign for "Muffins by Derpy")
It goes on like this, with references to Bejeweled (Rarity's method of sorting her gems), Cut The Rope (the CMC's previous activity of putting Angel in a box and suspending a carrot over his mouth via a complicated web of twine - none of them were very good at it, and Angel almost starved to death) and Fruit Ninja (Applejack and Rainbow Dash's hobby, which Rainbow livened up by using explosives). And then TechRat starts talking through a toy pig from Angry Birds, before throwing it off camera.
In Episode #4, Joe's announcement that "Unreliable Sources and throwing Freddy Baxter into a den of hibernating animals has confirmed that singing the song "Giggle at the Ghosties" is completely ineffective against bears."
This video essentially addresses the question "What would happen if Newborn Cuties!Scootaloo was planted into G4 Ponyville?"
And now MysteryBen27, the creator of those first two Rhythm Heaven crossovers, has created 'Foal in One' (which ends quite comically) and Remix Apple Apple Apple (with cameos from Parappa the Rapper and background characters from his previous videos).
Cardcaptor Derpy, which features Derpy Hooves (and those characters connected to her via fanarts) recreating the first OP to Cardcaptor Sakura (complete with a ponified subtitles for Catch You, Catch Me).
Even just the concept of HadesRiffs On "My Little Pony: Dusk's Dawn" is hilarious in itself, a god who enjoys trolling performs an MST on a low-quality fan-made episode. And the actual riff itself delivers well with some great quips.