From the first episode, when Max meets Skullmaster for the first time:
Max: Great! Then we can be friends? Shake?
*Skullmaster offers a demonic looking hand with an evil grin.*
Max: Whoa, whoa, whoa, on second thought...
Homer Simpson's dialogue when battling a lava monster in the first episode.
"What in the?! NOT THE CUPCAKES!!! Back! Back! TASTE MY LOUISVILLE SLUGGER, SUCKER!"
"The Cyberskull Virus" sees Norman and Virgil getting sucked into a videogame. Norman eating french fries and smelling roses (AKA powerups) is amusing enough, but seeing Virgil try to play it is amusing, as he's completely out of his element. It's like watching Einstein trying to play Call of Duty. Even better is the implication that Virgil actually starts to enjoy it (ironic, as he earlier called videogames childish).