* The first game has this moment.
--> '''Wily:''' As soon as I press this button...Bye bye world! '''[Wily proceeds to prepare to push the button. This involves raising his arm in the air, finger poised, and twitching]'''
* Anytime Wily laughs. His sprite animation nails it.
* The way Speedy Dave expressed how two kids deleted [=QuickMan=] and screwing over his ecoterrorism act.
-->'''Dave:''' How could 2 kids beat me, future head of Gospel! (IQ 170!!)
* Lan foiling Sunayama's hostage scheme in Battle Network 3 by chucking Mega Man's PET at his head and knocking him out cold. What he says while doing it sells it:
--> '''Lan:''' ''[chucks his PET]'' Megaman, attack!
* When seeing that Dr. Wily has a statue of himself, Lan kicks it off of a nearby cliff while making a remark about Wily's bad sense of design.
* Tensuke getting distresses by a malfunctioning [=TopMan=] during his scenario in Battle Network 4.
--> '''Lan:''' So why don't you just apologize? Netbattles are a lot funner if you enjoy them with friends.
--> '''Tensuke''' Nonsense!
--> '''[=TopMan=]''' Hah!
--> '''Tensuke''' Whatever happens, I'm still a master top craftsman!
--> '''[=TopMan=]''' Hah!
--> '''Tensuke''' I won't just apologize like it was nothing!
--> '''[=TopMan=]''' [[RuleOfThree Hah!]]
--> '''Tensuke''' [[BigShutUp SHUT UP!]]
* At the end of 5, Regal [[spoiler:undergoes a HeelFaceTurn and gives a talk to the heroes like a calm father figure. What makes this scene amusing is that said speech is accompanied by his evil angry mugshot from his villainous days. This was fixed in the Double Team DS re-release, where he gets a new mugshot that reflects his reformed status more.]]
* In 6, a plumber's Navi loses his tool program, and Lan and Mega Man find it stuck to a Mettaur's head. Lan tells Mega Man to delete the virus, but Mega Man doesn't want to since the program looks harmless and doesn't want to touch it.
* Every time the security bots ask to see Lan's ID in the sixth game.
* In a subversion of [[TalkingIsAFreeAction the usual procedures of the game]], Falzar/Gregar actually attack Mega Man in the middle of his "Battle Routine, Set!" dialogue.
* An NPC lawyer in Green Town who becomes incensed upon learning about a case of dieting scam.
--> "This will not be forgiven...''[[LargeHam NEEEEEVVVVVAAAAHH!]]''"
* Just about anything involving the Navi Customizer program Humor in 3-6. When installed, it allows Mega Man to make jokes to Lan when the L button is pressed.