Pepper: (up in Blythe's face) DO YOU UNDERSTAND THE WORDS THAT ARE COMING OUT OF MY MOUTH?
The second episode features Zoe's ability to not only eavesdrop conversations, but mimic with 90% more hammy-ness and hilarity. Including the scene where Zoe eavesdrops and mimics the conversation of Blythe and Mrs. Twombly. It shows Nicole Oliver's fun voice acting.
The Biskit Twins are mostly a walking CMOF as well.
From "Bad Hair Day", practically all of Blythe's desperate attempts to fix Zoe's fur after she botches it can count, including:
... sticking the cut fur back on by dumping an entire bottle of art glue over Zoe's head and body, then sweeping the fur into a square pile and rolling Zoe over it like a rolling pin,
... pulling out a wooden loom that just happens to be in a closet and weaving the fur into a dog-sized sweater,
... and, finally, SOMEHOW producing and melding a machine that projects a holographic image of Zoe. And in under a minute, no less.
"I've regained the will to harshly criticize the art world!"
Russel complains about the only headset Blythe could get being a "pink plastic toy". Hasbro being self-deprecating?
Zoe Trent is so deliciously hammy, she gives Rarity the run for her money as the walking CMOF most of the time.
Sunil's girly screamings, mainly after being touched by a leaf twice in "Gailbreak!".
The ending of "Gailbreak!" where it's revealed that the dog that they spent the episode rescuing from the Largest Ever Pet Shop was a male dog named Tootsie. When they return to the LPS and see Gail she points out that this isn't the first time Zoe has mistook someone else for her as to her all of the members of their breed look the same.
When Minka goes into her catatonic state, the pets try to snap her out of it...by throwing toys at her head.
Pepper gets a package. The others immediately start playing with the box.
Sunil's laugh. Enough said.
Vy's taunting to the Biskit twins about basketball could be this.
The Biskits' invitation to lunch:
Blythe [reading]: "You are cordially... ordered?
The Butler dancing during the BFF's song. The only way it could be funnier is if he started breakdancing.
In "Dumb Dumbwaiter", Vinnie asks if he could burp in front of the girls, and then he lets out a huge burp that's enough to knock out the pets, somehow open the gates of the Littlest Pet Shop and make Mrs. Twombly's stack of cans fall down.
In "Blythe's Crush", Zoe, upon getting into the music the band is playing, grabs the microphone and starts singing another amazing song. And then the camera zooms out and the crowd is wondering why some random dog is barking into the microphone.
The entirety of Mrs. Twombly's Sanity Slippage in "Eve of Destruction". One good example being when she goes to get her special cleaning formula from the all-natural retailer she usually gets it from and she's mad because they stopped stocking it "because of a little added jet fuel".
Some of the best gags are the little reminders that the pets are still animals, not people:
Pepper admitting she has no concept of time.
When food spills into a giant pile on the floor, all the pets immediately dive in.
Zoe enters the room, asking, "Has anybody seen my squeaky hamburger?" Heck, Zoe Trent managed to be even more hammier than usual during "Eve of Destruction" especially when it involves Madame Pom around.
Sunil fighting hundreds of cobras at once. Cut to a confused woman watching a mongoose jumping around on the floor attacking random merchandise.
Blythe's spatial awareness skills are bizarre. When looking for Russell in school, she looks under a student's lunch tray. When looking for the lost truck, she checks under the ramp it left behind.
One from the episode where the pets get out of the shop. The show's bizarre character proportions are lampshaded when Blythe tries to fit through the hole they escaped through, only to find out she can't. This leads her to shout "CURSE MY FREAKISHLY LARGE HEAD!"
She gets her head stuck again, this time in Shiver's tree home in "Blythe's Pet Project".
In "Commercial Success":
Jasper: No need to worry your pretty little oversized head. Blythe:(muttering) I'm not the only one with a big head.
Mrs. Twombley's family gets obscure, Victorian-era diseases, including "the vapours", "the quinsey" and "the rising of the lights."
Blythe's first interview in "Terriers & Tiaras", staring at the camera in a catatonic state, giving her name as the answer to every question.
Blythe going Stage Mom in "Terriers & Tiaras". Mostly. Even funnier the fact Ashleigh Ball seemed to be looking for an excuse to use her Applejack voice.
The song the pets sing for Blythe at the beginning of the season finale is contender for saddest moment of the entire show, but even then the writers couldn't avoid throwing in one or two jokes. Sunil sings about how his tears risk flooding the room, then Vinnie adds that luckily he's standing next to the drain. And Pepper "Was it something that I said? Did I joke too much about her (Blythe's) giant head?"
"99 cans of pet food on the shelf....."
Mrs. Twombly calling the F.U.N. security guard "young man" when he's clearly middle-aged.
Eight Arms to Hold You
After many failed attempts to break into Littlest Pet Shop, Sunil tries kicking Vinnie high enough to reach the open window..... He kicks too hard.
"Great, we look like two clowns after playing in a sewer!"
Mrs. Twombly's Imagine Spot where she guesses how the pets speak and act and gets it completely wrong.
The other pets laugh about the pet psychic getting their personalities completely wrong. Vinnie doesn't understand.
Vinnie: What do you mean? She said I was smart.
A Day at the Museum
Vinnie and Sunil ditching Pepper while both agreeing they'd rather be eaten by zombies than tolerate her smell.
Alligators and Handbags
Vinnie's tail falling off with a 'pop' sound after Wiggles threatens to eat him.
Blythe follows her dad's advice and imagines Mona Autumn in a moose costume; Cue a shot of Mona in said costume, making a moose sound, with a flaming background behind her.
At the beginning Sunil manages to scream so loud that it reaches a frequency only Zoe can hear.
When Zoe and Minka try to get used to being a mixed breed and an endangered species, respectively, Zoe develops a Joisey personality and Minka acts like royalty.
At the end of the revised commercial, when Jasper amazingly voices the pets as their exact voices, but in the wrong bodies.
Russel warns Minka to watch out for "gramma rays".
The entire A-plot. Being a parody of Weekend at Bernie's with wacky cartoon animals, how can they go wrong?
The antics of the love-struck pets.
When Russell revives his "Cyril McFlip" persona, the other pets begin singing the song of the same name from "Sunil's Sick Day", but he stops them with a curt "That's enough of that!"
Russell and Penny pretending to be a couple to lure the Cupet, with Russell saying awkward forced romantic compliments. Adding to that is their outrageous outfits (Penny with a beehive hairdo, and Russell wearing a deerstalker cap and a large fake mustache) But the best part is Blythe's reaction while watching them from the background. One of the best "What the hell!?" looks in the entire series.