If it's not a CMoH, it's probably a CMoF. But the one scene that probably takes the cake is when Gabe breaks his arm. There's never been a scene that's so heart-wrenching (you really do feel for the guy) and yet still so hilarious.
The first two minutes of the film. Gabe is discussing how much he knows about relationships, and quickly gets to the subject of cooties. We're then treated to a scene in which one of a group of boys goes into hysterics over being poked in the arm by a random little girl, thus apparently receiving cooties. While he's on the ground screaming, his friends get chased away by another little girl.