Episode 2 has Kirby kicked out of the castle by Dedede. His friends try to build him his own house. After many trials and much tribulation they succeed, only for Kirby to take up residences in the tree nextdoor! Though the bird he'd stolen the tree from seemed happy with it...
In "Un-Reality TV," Dedede uses his televisions to brainwash almost everyone into attacking Kirby...including Kirby himself.
In "The FoFa Factor," after Kirby gets split into small male and female versions of himself, Escargoon comments that everyone probably has a male and female side to them. This leads to both Escargoon and Dedede imagining what a female version of the other character would look like. This makes them both shudder.
Moments later, this split ends up happening to Dedede. The two sides promptly freak out.
Meta Knight kicking Dedede's car down a hill—after saying he was his most loyal servant.
Although mostly known for its appearance in the Japanese version, Dedede and Escargoon's bickering as the car rolls down the hill in the dubbed version is good as well-
Meta Knight: Sire, it is my duty to warn you. Kirby has great power, now.
Dedede: Yeah? Well who's the King around here, you or me?
The end results of episode 49 (Cartoon Buffoon)- Dedede Comin' At Ya!. In case you're wondering: It's a poorly written, hilariously hammy version of the first episode of the anime, except Dedede is Kirby and Kirby is the Demon Beast. Hilarity Ensues
Hell, the whole thing. It's filled with a ton of subtle and not-so-subtle jokes about animation.
Really, Meta Knight's status as The Comically Serious lends itself well to these kinds of moments. Another example would be in Episode 61 (Fitness Fiend), where everyone else breaks into dancing with Max Flexer (Macho-San in Japan) while he just stands there stiffly.
Fitness Fiend, where NME saved the day by working Kirby out.
Kirby ends up eating a whole pack of Gijira extract, which is a spice and a hallucinogen. Once Kirby swallows the entire pack, he thinks EVERYONE is food, and ends up preparing cooking utensils with the intention of eating everyone.
Dedede's attempts to avoid Kirby after having several nightmares about the pink puffball in Part 1 of Prediction Predicament.
In the first episode, the mayor and the rest of the Cappies hold a feast for Kirby's arrival. Kirby then proceeds to eat the entire table of food using his inhale ability (Including the tablecloth and utensils!), leaving the rest of the guests in utter silence.
Dedede revealing and talking through his wonky painting in Dedede's Monsterpiece-
[Points to his tiny castle, and a giant misshapen-looking Escargoon next to it] Right there is my castle, and right next to it is Escargoon. Note the lack of depth!
[Points to an awkwardly-angled version of the Mayor with noodle arms and two giant angry Pac-Man-like sheep behind him] This here's the Mayor being chased by his sheep, [Points to a misshapen Kirby in the corner of the painting] and this here's Kuhbeh. He's being chased by me! See, I drawed him all lumpy to express his inner lumpiness!
Even better- when everyone does break down in laughter at it, Kirby is the only one not laughing- he's still glaring at Dedede in a hilariously-angry way over being called lumpy!
It's even funnier in the original version because that's NOT the reason Kirby gets mad at him. The real reason is because Dedede drew Kirby shitting himself!
Dedede's twisted version of "Old Macdonald" from Kirby's Egg-cellent Adventure, which he sings at a ridiculous speed as he's using his tank to draw a giant picture of Kirby eating Dyna Blade's egg (Complete with big goofy grin and oversized knife and fork) to get the giant bird to attack him-
And later on in the same episode, when Tiff asks Meta Knight for advice on the matter. What really sells it is Tiff's "WTF" tone and expression upon hearing his reply, in the middle of a mostly-serious scene-
Tiff: Help us Meta Knight, we've got to do something!