* Have you ever seen the back of a twenty dollar bill...''on weeeeeeeeed''?
*
-->Why don't we sell that stuff we smoked last night?
-->You suggested that already!
-->I did?
-->''(disconnected number tone)'' Marijuana affects the memory.
* The opening [[AMinorKidroduction Minor Kidroduction]] with the four main friends ''as kids'' doing weed for the first time.
* Marijuana's not a drug! [[MemeticMutation I used to suck dick for coke!]] (I've seen him!) Did you ever suck some dick for marijuana?
** BOO THIS MAN! BOOOOOO!
* The guys flying around New York City complete with the epic background score (somewhat parodying ''Film/{{Superman}}'') as a visual metaphor of them getting high. The StylisticSuck of the effects add to the humor.
** Scarface's dog, Killer also does this when stoned.
* Thurgood's date with Mary Jane and his attempt to manage his budget of only 8 dollars.
** "4 YEARS, JUST FOR WEED?...DAMN".
* Thurgood and Mary Jane's lovemaking depicted as a picture slideshow.
-->'''Thurgood:''' "I got some boo-ty, I got some boo-ty".
* Brian in general. Jim Breuer gives a hilarious, spastic performance of a guy just completely stoned out of his mind at any given time.
* Brian's theory of how [[spoiler:Killer was murdered]].
* The completely random Guy on the Couch (Stephen Wright) and the fact that's his staying at the apartment is never really explained.
*
-->''(Thurgood)'' Where are we gonna find a Jamaican?
-->''(Brian - White Guy)'' I'll pretend I'm Jamaican.
-->''(Thurgood)'' You have smoked yo'self retarded.
* "Sir Smoka Lot" (Dave Chapelle in a duel role), especially when opening up to Thurgood about his not-so glamorous life.
* Scarface quitting his job "Fuck you, fuck you, fuck you, you're cool, fuck you, I'm out".
** The "cool person" is an elderly female customer who responds with a deadpan thumbs up.
** Also when Brian quits his job telling everyone he's not gonna "freak out" and almost nobody cares.
* The old granny doing weed: "...and it's good for arthritis too''.
* Hey Girl, you hungry?
** Fuck you nigga!
*** Or in the TV version "Up Yours Honky!"
*
-->'''Brian:''' Well you said you gave Mary Jane a [[UnusualEuphemism "pearl necklace"]], how much did that cost man?
-->'''Thurgood:''' You know obviously you missed the point of that story, Brian.
* "The ''horse'' is a ''diabetic!''"
* "And hey! If I'm not back in ten minutes... call the ''police''!" "If he ain't back in ten minutes, we callin' Domino's!"
* Kenny: "I'm somebody's bitch" (saying it with feigned pride).
* The cops in the van during the wiretap sting getting stoned from the residual refer smoke laughing at Thurgood's love letter to Mary Jane.
-->"You're all the Mary Jane I'll ever need" (both laugh hysterically).