* "I'll bet you twenty bucks I can get you gambling before the end of the day!"
** Even better in that he doesn't realize he's already won.
* Lloyd's [[LaxativePrank revenge]] on Harry, the funniest [[PottyEmergency diarrhea scene]] ever committed to film.
** Lloyd's EvilLaugh after the prank has taken place, complete with the Wicked Witch of the West's theme.
* "His head fell off?!"
** Even funnier is Harry's follow-up, "Yeah, he was pretty old..."
-->'''Lloyd:''' That's it. I've ''had it'' with this dump! We got no food, we got no jobs! Our pet's '''HEADS ARE FALLING OFF!!'''
* When Lloyd accidentally goes the wrong way during the road trip:
-->'''Harry:''' Huh. I expected the Rocky Mountains to be a little rockier than this.
-->'''Lloyd:''' I was thinking the same thing. That Music/JohnDenver's full of shit, man.
* When Lloyd pulls up next to Harry on a Vespa, and explains that he sold the Shaggin' Wagon for it and gas money.
-->'''Harry:''' Where did you find that?!
-->'''Lloyd:''' Some kid back in town. Traded the van for it straight up. I can get 70 miles to the gallon on this hog.
-->'''Harry:''' [{{Beat}}] [[IHaveJustOneThingToSay You know, Lloyd, just when I think you couldn't possibly be any dumber,]] [[TranquilFury you go and do something like this]]... ''[[BaitAndSwitchComment and totally redeem yourself!]]''
* Lloyd runs to catch Mary's plane before it leaves.
-->'''Airport staff:''' Sir! You can't go in there!
-->'''Lloyd:''' It's okay! ''[flashes badge] I'm a limo driver!''
** ''"MOVE IT OR LOSE IT, SISTER!"''
* The diner scene where Harry and Lloyd eat hot peppers. Their subsequent, simultaneous flip-out [[https://www.youtube.com/watch?v=J7L9THry9QM should be seen to be fully appreciated.]]
* Lloyd is leaving the bar when he sees a copy of an old "Man Walks On The Moon" headline framed on the wall. Taken aback, he walks outside and screams [[ComicallyMissingThePoint "WE LANDED ON THE MOON!!!"]][[note]]This was [[ThrowItIn ad-libbed]] by Jim Carrey, to boot.[[/note]]
* "Wanna hear the MostAnnoyingSound in the world? '''''[[MostAnnoyingSound AAAAAAA]][[HellIsThatNoise AAAAAAA]]...'''''"
* Harry introduces himself to Mary by saying "Nice set of hooters you got there" completely out of the blue. Although he makes a quick save by claiming that he's referring to the snow owls.
* The snowball fight between Harry and Mary. After Mary playfully tosses some snow at Harry, he retaliates by [[DisproportionateRetribution pegging her in the face with a snowball at point-blank range as hard as he can]]. It goes downhill from there. ('''Literally.''')
* Lloyd's dream sequence, which involves the GroinAttack to end all Groin Attacks, ripping a guy's heart out, a kiss from hell, and ends with Lloyd nearly hitting a semi head-on.
* Harry and Lloyd replacing the ransom money with I.O.U.s. Watching how they spend it is funny enough, but then [[ChekhovsGag the Big Bad finally opens the briefcase at the end]] and nearly blows a gasket.
-->'''Lloyd:''' Go ahead and add it up. Every cent's accounted for. Look, see this? That's a car. 275 thou. Might wanna hang onto that one.
* When Harry explains that he survived getting shot because the FBI gave him a bulletproof vest.
-->'''Lloyd:''' ...[[FridgeLogic what if he shot you in the face?]]
-->''(beat)''
-->'''Harry:''' ''(to FBI)'' [[DumbassHasAPoint What if he shot me in the face?]]
-->'''FBI:''' [[TheNeedsOfTheMany That was a risk we were willing to take.]]
* The look on Harry's face when Lloyd has his hand in his coat [[spoiler:(ready to pull his gun during his ImagineSpot)]].
* Lloyd outwits Sea Bass at the diner by somehow getting him to put their lunch on his tab.
-->'''Harry:''' That was genius, Lloyd, sheer genius. I mean, where did you come up with a scam like that?
-->'''Lloyd:''' Saw it in a movie once.
-->'''Harry:''' That's incredible! So what happened, so the guy tricks some sucker into picking up his tab and gets away with it scot-free?
-->'''Lloyd:''' No! In the movie, they catch up to him a half-mile down the road and slit his throat. ''(giggles)'' It was a good one!
-->'''Harry:''' ''([[OhCrap suddenly driving a LOT faster]])''
* When Lloyd first suggests to Harry that they go to Aspen.
-->'''Lloyd:''' What are we doing here, Harry? We've gotta get out of this town!
-->'''Harry:''' Yeah, and go where? Where do you wanna go?
-->'''Lloyd:''' I'll tell you where: someplace warm. Where the beer flows like wine. Where beautiful women instinctively flock like the salmon of Capistrano. I'm talking about a little place called ''(whispers) Assspeeen''.
-->'''Harry:''' I don't know, Lloyd; the French are assholes.
* Also the PottyHumor where Harry just lets go and pees during the ride... the pair are frozen together by the time Lloyd stops.
* "Dear Gas Man, packed up and drove to Aspin. Sorry about the $. Lloyd and Harry." *smiley face*
** Even funnier since [[MistakenForBadass the villains think that Harry and Lloyd are criminal geniuses playing them for fools]], taking "Gas Man" to be a reference to Mental's ulcer problems.
* "Hey...you wanna hear the most annoying sound in the world?" Doubly funny if you watch Creator/JeffDaniels [[{{Corpsing}} start to lose his shit]] before the camera cuts to Mike Starr, also trying not to laugh.
* At the bar while Lloyd is waiting for his supposed date with Mary, Beth shows up and starts [[MotorMouth rambling]] about her [[spoiler:non-existent]] ex-boyfriend:
-->'''Beth''': And I said: "Run, Beth, run for your life before this man kills you both." Then do you know what the klutz did?
-->'''Lloyd''': ''(in HeadDesk)''...No, and I don't...'''''CAAAARE...''''' ''(back to HeadDesk)''
* Lloyd's attempt at a LoveConfession is fantastically stupid. This line is just the tip of the iceberg: ''"What do you think the chances are of a guy like you and a girl like me..."''
** And then when Mary tries to tell him it's "more like one out of a million":
-->'''Lloyd:''' [[CompletelyMissingThePoint So you're telling me there's a chance?]] [{{Beat}}] '''YYYYYYYEAH!!!'''
** Lloyd practicing a big romantic speech, ultimately screwing it up in, of course, the most hilarious way he could.
-->'''Lloyd:''' I desperately wanna make love to a schoolboy.
* The final scene in the movie was originally supposed to [[spoiler: have Harry's line be the same, then Lloyd would actually get them on the bus with the bikini models]]. The finished ending is the result of Creator/JimCarrey looking at the scene and going "Well yeah, but wouldn't ''this'' [[RuleOfFunny be even funnier]]?"
* The trailer for the movie, especially this line: "If they each had half a brain, they'd still only have half a brain."
* Doubles with an inversion of FridgeBrilliance: Harry and Lloyd pick up Mental as a hitch-hiker, despite the fact that they SAW him at their apartment, with a gun, merely days before. Neither even thought to mention "hey, doesn't this guy look a lot like the gas man?"
** Although Mental did have his back to them when they were looking through the peephole.
* This completely pointless line, as Lloyd leaves a convenience store:
-->'''Lloyd:''' Hey, guys! Oh, Big Gulps, huh? All right! [{{Beat}}] Well, see ya later!
** This brief 8-second scene was devised by Carrey to show that while Lloyd may be a moron and a sociopath, he's not a ''racist'' moron and sociopath.
* Harry is depressed that Mental's last words were calling them out on murdering him. Lloyd replies "not if you count that gurgling sound."
* TheCameo from Canadian comic Harland Williams as a state trooper, in which he pulls Harry and Lloyd over to intimidate them, then swipes one of their beer bottles for good measure, and takes a swig. [[spoiler: Lloyd's spent the last few minutes [[IAteWhat peeing in those bottles]].]]
* After inadvertently insulting an old lady he asked to watch his stuff while he got change for a dollar, Lloyd comes back to find all the stuff gone. He returns to their apartment, slams the door, then melodramatically falls to the floor and loudly announces to Harry:
-->'''Lloyd:''' I got robbed by a sweet old lady on a motorized cart, and I DIDN'T EVEN SEE IT COMIN'!
* While watching Mary leave through the airport while driving his limo outside, Lloyd attempts a dramatic farewell with arm outstretched, but crashes into the car in front of him halfway through:
-->'''Lloyd:''' Goodbye my love-OOOOAHHH! [airbag is deployed into his face]
* Lloyd just remembered to give Harry the extra gloves he had while in Aspen, with Harry understandably furious at him for not sharing them with him while his hands were freezing cold. The funny part is when Lloyd is completely oblivious to his friend's anger and how, when Harry chokes him for revenge, we get this amazing line:
-->'''Lloyd:''' ''EEEAAAHHH!'' HARRY! [[ComicallyMissingThePoint YOUR HANDS ARE FREEZING!]]

----