Black Fire, White Ice. It starts out serious enough, but then when Baron starts talking, it goes to hilarious. After making a spectacle of himself (as usual), Sasha goes and insults his manhood. Cue the Shout-Out and squeeling fanbase. "Aw Hell naw!" So now Baron has Jack go on his way to pick a fight with "Barbitchka". Just as we leave, we're left a pure gem.
Jack: She's all yours Baron...If you have the endurance.
The beginning of The Wounded Beast. The Baron makes a minor spectacle of himself as usual, and stylishly whips out his Killer Weapon, declaring that he's gonna help Jack find Max. Jack just turns silently and turns him down with "I work better alone." Cue Baron's disappointed face as he silently retracts his Killer Weapon. Made even better by the whoopie cushion-like sound effect that accompanies it. You can just hear the Baron's ego deflating.
When preparing for a multiplayer game or practice session of said multiplayer, when selected, each character will break out of what they were doing somehow and and do something Badass. All except Mathilda, who is cleaning glasses. When she is selected, she puts a glass she was cleaning on the shelf, while the camera zooms in on her (damn fine!) ass. Without any warning, or even flinching, she backhandsthe camera out of nowhere, causing a crack to appear on the screen. Probably one of the more literal instances of Breaking the Fourth Wall.
In the Butcher's Banquet mission, Rinrin and Big Bull both decide to help Jack fight Zero's new robot, to his cynical bewilderment.
The best part is that after Zero gets beaten, he goes along with Jack's 'super friends' nickname. And then Rinrin tries to start an argument with Big Bull over who helped Jack more.
In Round 10 of Survival Mode's third stage, there are five Gargoyles that need killing. This wouldn't be too notable, if not for the fact that they have the colours red, blue, green, yellow and pink. They all come together to perform a "Super Sentai" Stance complete with background explosion! Sound like anyone you know?
After the Black Side mission 1-3, Jack calls off his fight with the Baron after Amala calls him with information about the BPS Strike One. As Amala describes Sasha to Jack, this exchange takes place:
Amala: She was only on the force for two years before being selected for her current post.
When Big Bull executes a mutant, he uses a drillfrom his right arm to mutilate it until it explodes. The head of the mutant then ends up in Big Bull's hand, which he nonchalantly tosses over his shoulder like something he's lost interest in.