Abraham is one of the Faithful, the group that maintain that sooner or later, "the heroes will come." As of the beginning of Mitosis, they have. We see that Conflux is openly serving the city by providing power, and Prof uses his powers to help the Reckoners protect Newcago. For quite possibly the first time, we have Epics using their powers not to enslave or dominate, but to serve. The heroes have come.
If an Epic's weakness has something to do about their past, then it provides an interesting clue about Steelheart. He can only be killed, let alone be harmed, by someone who isn't afraid of him. Which could mean that he may have been a sort of bully in the past and had an incident with someone who finally stood up to him. Then there's Nightwielder, whose weakness is sunlight, or simply UV rays being flashed at him. This may imply, along with his Asian features, that he may have been an Otaku, or simply put, a shut-in before his Epic days.
Edmund/Conflux said he 'thought' his weakness was being near a dog, but it apparently wasn't as bad as he thought. How would he know this if he hadn't actually gone as near a dog as he dared to test this out?This explains his humble and good behavior above and beyond his being a gifter Epic. It's because he has already overcome the corruption, albeit unknowingly. He IS the first good Epic.
Firefight strongly implies that Calamity is a gifter Epic, one who has gifted his powers to every other Epic. And we know that if you kill a gifter, his gifted powers die with him. Kill Calamity, and every Epic will be depowered. Of course, killing Calamity may be a bit difficult.
Rule of Symbolism in play here as the first seemingly benevolent Epics David meets in Steelheart and Firefight both share the role as sustainers for their respective cities. Both effectively use their powers for the sake of others as opposed to using it to serve themselves and dominating others with it.
Prof was a fifth-grade science teacher at an elementary school until that school was destroyed by an Epic. Prof is an Epic and is hinted to have done terrible things in his past. Which Epic destroyed his school?
Prof is a true Epic now. Almost the first thing he did was try to kill his fellow Reckoners, since he knows more than anyone else just how dangerous they can be. And he's the one person who knows all the Reckoners' identities and locations.