When Roahm Mythril did his weapons demos, he also included which Nezumi was weak to which weapon and had a logical reason for 7 of the 8 (example: Dragon Nezumi's weakness: "Pokémon type science at work".)note Though a reviewer may have had a better reason for Butter Nezumi's weakness, and Word of God says that Milky Nezumi's weakness was for a different reason. The one he didn't have any idea about was Wave Nezumi being weak to the Dragon Cluster. I think I have the answer: What are dragons famous for? 1. Fire Breath, 2. Flying, 3. Being Scaly, 4. Hoarding shinies, and 5. Kidnapping Princesses. Hence, this weakness works best (and only) if Wave Nezumi is indeedThe One Girl. (Though that does bring up a bit of Fridge Logic regarding Usagi the Kangaroo.) - Donald the Potholer
Why is Wave Nezumi the only one with an Ambiguous Gender? Well, it's possible that they may in fact be genderfluid.