* ''LightNovel/BakaAndTestSummonTheBeasts'':
** Boys: Akihisa Yoshii (choleric), Yuuji Sakamoto (phlegmatic), Hideyoshi Kinoshita (melancholic), and Kouta Tsuchiya (sanguine).
** Girls:Minami Shimada (choleric), Shouko Kirishima (phlegmatic), Mizuki Himeji (melancholic), and Aiko Kudou (sanguine).
* Although everyone in ''Manga/BigWindup'' gets his/her turn to shine, the story tends to focus on four core members of the baseball team:
** TheCaptain Hanai (choleric), TheStrategist Abe (melancholic), FragileFlower Mihashi (phlegmatic), and CloudCuckoolander Tajima (sanguine).
* ''Manga/BlackLagoon'':
** SociopathicHero Revy (very choleric), WideEyedIdealist Rock (melancholic), BaldBlackLeaderGuy Dutch (phlegmatic), and MissionControl Benny (sanguine).
* The original ''Anime/BubblegumCrisis'':
** Choleric: HotBlooded badass Priss.
** Melancholic: [[TheStoic Stoic]] leader Sylia.
** Phlegmatic: Linna the average Jane.
** Sanguine: Perky and [[TheDitz ditzy]] Nene.
* ''Manga/ChronoCrusade'':
** Sanguine: [[NunTooHoly Rosette]] (HotBlooded, cares a lot about others but has a violent temper).
** Choleric: [[MsFanservice Satella]] (prideful, determined, and focused on her revenge).
** Melancholic: [[HeroicAlbino Azmaria]] (a prodigy singer, very caring about others, but insecure and hard on herself).
** Phlegmatic: [[FailureKnight Chrono]] (compassionate and nurturing, but easily discouraged)
* The four Dark Masters in ''Anime/DigimonAdventure'' fit this trope:
** Choleric: The leading element Piedmon.
** Melancholic: The cold and calculating EvilGenius Machinedramon.
** Phlegmatic: Pragmatic Metalseadramon, who's a good boss towards his minions as long as they don't fail him.
** Sanguine: Puppetmon, with his HotBlooded PsychopathicManchild demeanor.
* ''Anime/DigimonTamers'': Rika (choleric), Henry (melancholic), Takato (Phlegmatic) and Jeri (sanguine)
** ''Anime/DigimonSavers'' has two sets:
** The main cast:
*** HotBlooded Marcus (choleric), TeenGenius Thomas (melancholic), FauxActionGirl Yoshi (phlegmatic), and WildChild Keenan (sanguine).
** The original expedition:
*** GeniusBruiser Spencer (choleric), BigBad Kurata (melancholic), CoolOldGuy Yushima (sanguine), and {{Good Parent|s}} Criers (phlegmatic).
* ''The Melancholy of LightNovel/HaruhiSuzumiya'': Haruhi (sanguine, despite the title), Koizumi (choleric), Kyon (melancholic), Mikuru (melancholic), and Yuki (phlegmatic). Tsuruya, [[SixthRanger an honorary member of the Brigade]], also fills the purely choleric position.
* ''Manga/{{Hellsing}}'' has three:
** The Hellsing Organization: Alucard (choleric), Seras (phlegmatic), Walter (melancholic), Pip (sanguine) and Integra (leukine).
** The Iscariot Organization: Alexander Anderson (sanguine), Heinkel Wolfe (choleric), Yumie Takagi (phlegmatic), and Enrico Maxwell (melancholic).
** Millennium: The Major (sanguine), The Captain (melancholic), Doctor (phlegmatic) and Schrodinger (choleric).
* ''Franchise/{{Jewelpet}}''
** ''Anime/JewelpetHappiness'' has the boys quartet: Kousuke is phlegmatic, Takumi is melancholic, Mouri is sanguine and Taira is choleric.
** ''Anime/LadyJewelpet'' has two sets: the Petit Ladies are Momona (sanguine), Lillian (melancholic), Mizuki (choleric) and Charon (phlegmatic); the SixthRanger Elena is leukine. The Princes are Cayenne (leukine), Romeo (phlegmatic), Soarer (melancholic) and Levin (sanguine); the SixthRanger Miura is choleric.
* ''Manga/JoJosBizarreAdventure Startdust Crusaders''
** Joseph Joestar (eclectic), Jotaro Kujo (choleric), Noriaki Kakyoin (phlegmatic), Mohammad Avdol (melancholic), and Jean Pierre Polnareff (sanguine).
* ''LightNovel/KaraNoKyoukai''
** Ryougi Shiki (melancholic), Kokutou Mikiya (phlegmatic), Aozaki Touko (choleric), Kokutou Azaka (sanguine)
* ''Manga/TheLegendOfZelda'': The [[http://www.newgrounds.com/portal/view/328825 flash animations by Hadouken Dude]] took this to absolutely hilarious levels, with Green Link being loyal/humble, determined and moralistic/uptight (melancholic), Blue Link being analytical/nonchalant, witty and sarcastic/condescending (phlegmatic), Red Link being hot-tempered/brash, impatient and perverted/selfish (sanguine), and Purple Link being naive/greedy, idealistic and clumsy/overly dependent on others (choleric), also accused of being gay because of personality and color.
* The Hinata House Girls in ''Manga/LoveHina'':
** Naru Narusegawa & Motoko Aoyama (choleric), Mitsune Konno (melancholic), Kaolla Su (sanguine), Shinobu Maehara (phlegmatic), and Mutsumi Otohime (eclectic).
* ''Anime/MagicalGirlLyricalNanohaStrikers''. natural leader (former) {{Tsundere}} Teana (choleric), knight-in-training Erio (melancholic), Caro (phlegmatic), and GenkiGirl [[ThePollyanna Pollyanna]] Subaru (sanguine). The last two's personalities actually caused a bit of family drama for their also melancholic adopted mother in the second [[AudioAdaptation StrikerS Sound Stage]], since [[NonverbalMiscommunication their combined introvertedness caused some communication problems]].
* The current lineup of the Taishiro in ''Manga/SamuraiDeeperKyo'' fits almost flawlessly.
** Sanguine: Yuan is extroverted, fond of wisecracks, and very protective of the people he cares about. He uses fire techniques and wears red.
** Choleric: Tokito is quick to anger, perfectionistic, and impulsive. Wears shades of yellow, and fights with a very aggressive energy.
** Melancholic: Hishigi is exceedingly introverted and the epitome of TheStoic, analytical and extremely task-focused. He shows textbook signs of severe depression. His color scheme is almost entirely black.
** Phlegmatic: Fubuki leads the Taishiro. He is level-headed, cultured and elegant. His fighting style revolves around water and his color scheme is mainly blue.
* ''Anime/{{Superbook}}'' (second season): Christopher Peepers (choleric), Joy (melancholic), Uriah (sanguine), and Gizmo (phlegmatic).
* The four main characters from ''Anime/{{Texhnolyze}}'': [[HotScientist Doc]] (sanguine), [[OnlySaneMan Onishi]] (choleric), [[TheStoic Ichise]] (phlegmatic), and [[WaifProphet Ran]] (melancholic).
* Five-temperament ensemble in ''Manga/TokyoMewMew'': At first [[IJustWantToBeNormal not happy about leading]], but accepting her responsibility later on, Ichigo (choleric); Minto (melancholic), Retasu (phlegmatic), the GenkiGirl Bu-ling (sanguine), and Zakuro (eclectic).
* ''Anime/TheTowerOfDruaga'':
** Jil's Group: Jil (melancholic), Ahmey (phlegmatic), Melt (choleric), Coopa (sanguine), and Kaaya (eclectic).
** Neeba's Group: Neeba (melancholic), Fatina (choleric), Kally (phlegmatic), and Utu (sanguine).
* ''Manga/{{Trigun}}'' more often averts this trope in favor of the [[TheDrifter Lone Hero]] or the PowerTrio. Adding Wolfwood to the cast has a subtractive effect instead, generating a [[RedOniBlueOni duo dynamic]] that leaves Meryl and Millie on the sidelines. When they participate equally they fit the four temperaments: Meryl (choleric), Vash (melancholic, though pretending to be sanguine), Wolfwood (phlegmatic), and Millie (sanguine).
* In the original ''Anime/WeissKreuz'' Aya (choleric), Omi (melancholic), Youji (phlegmatic), and Ken (sanguine).
* In ''Anime/WolfsRain'': Tsume (choleric), Kiba (melancholic), Toboe (phlegmatic), and Hige (sanguine).
* ''Manga/YourLieInApril'': Arima Kousei (melancholic), Miyazono Kaori (choleric), Watari Ryota (sanguine), Sawabe Tsubaki (phlegmatic).
* ''Anime/YuGiOh5Ds'': Jack (choleric), Yusei (melancholic), Akiza (phlegmatic), and Crow (sanguine).
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