Dragon Age II has Merrill (sweet and naive, wants to help her people) and Sebastian (deeply religious) as Idealists, Aveline (protector, group conscience) and Varric (savvy, level-headed merchant prince) as Realists, Fenris (traumatized, bitter, and snarky warrior) as Cynic, and Isabela (flighty hedonist) as Apathetic. Anders straddles the line between Cynic and Idealist, being a Well-Intentioned Extremist who combines self-sacrificing loyalty to his ideals with hostility and ruthlessness. Hawke themselves takes the role of the Conflicted, a Sad Clown who tries to maintain the peace in Kirkwall and amongst their companions, but often lets their desire for stability prevent them from being more proactive.
The Ever17 female cast: You (the Optimist), Tsugumi (the Cynic), Sora (the Realist), and Sara/Coco (the Apathetics).
Everworld - Jalil (the Cynic), David (the Optimist), April (the Realist), Christopher (the Conflicted), and Senna (something of the Apathetic).
Final Fantasy XIII: Hope (the Cynic), Snow (the Optimist), Lightning (the Realist), Fang (the Apathetic), and Vanille and Sazh (the Conflicted).
Gears of War 2: Marcus as Cynic, Domin Santiago/Cole the train as Optimist, Baird as Realist, Dizzy as Apathetic
Half-Life 2: Barney Calhoun (the Cynic), Alyx Vance (the Optimist), Dr. Kleiner (the Realist), and Dr. Mossman (the Apathetic).
The first Knights of the Old Republic: Carth's a Cynic. Mission is very much an Optimist. Canderous is Apathetic (a Mandalorian on a boatload of Jedi and Republic sympathizers, and has nothing better to do). Bastila looks like a Realist, but is actually Conflicted. Juhani appears Conflicted, but bends more Realist. Zaalbar is also Conflicted (you can influence him to the Dark Side pretty easily). The droids are Apathetic (T3 hasn't lived long enough to develop a personality; HK-47 just wants to shoot things for the meatbag in charge). Jolee likes to ride the line between Cynic and Apathetic.
Left 4 Dead: Francis who hates everything (the Cynic), hopeful Louis (the Optimist), Bill the experienced (the Realist), and, knowledgeable on zombies, Zoey (the Apathetic).
Left 4 Dead 2: pessimistic Nick (the Cynic), naive Ellis (the Optimist), Coach as leader (the Realist), and Rochelle, the only neutral character (the Apathetic).
The Legend of Dragoon. Dart is the Realist, Lavitz is the Optimist, Rose is the Cynic, Shana is the Conflicted. Haschel later joins as the Apathetic. This setup holds from the time Rose joins all the way until Dragoon's It Was His Sled moment happens, where it transitions into a proper Five-Man Band.
Mega Man Zero — Among the Four Guardians, plus their master in the first game: Copy-X (the Cynic), Phantom (the Apathetic, although pragmatic), Harpuia (the Conflicted), Fefnir (the Optimist), and Leviathan (the Realist).
Metroid Prime 3: Corruption: Samus (the Conflicted, sometimes the Realist), Ghor (the Cynic, sometimes Conflicted), Gandrayda (the Optimist), and Rundas (the Apathetic and pragmatist).