Dragon Age II has Merrill (sweet and naive, wants to help her people) and Sebastian (deeply religious) as Idealists, Aveline (protector, group conscience) and Varric (savvy, level-headed merchant prince) as Realists, Fenris (traumatized, bitter, and snarky warrior) as Cynic, and Isabela (flighty hedonist) as Apathetic. Anders straddles the line between Cynic and Idealist, being a Well-Intentioned Extremist who combines self-sacrificing loyalty to his ideals with hostility and ruthlessness. Hawke themselves takes the role of the Conflicted, a Sad Clown who tries to maintain the peace in Kirkwall and amongst their companions, but often lets their desire for stability prevent them from being more proactive.
Sly Cooper: Sly (the Apathetic/Realist), Bentley (the Cynic), Murray (the Optimist), Carmelita (the Conflicted).
Ever17 female cast: You (the Optimist), Tsugumi (the Cynic), Sora (the Realist), and Sara/Coco (the Apathetics).
Everworld - Jalil (the Cynic), David (the Optimist), April (the Realist), Christopher (the Conflicted), and Senna (something of the Apathetic).
Final Fantasy XIII: Hope (the Cynic), Snow (the Optimist), Lightning (the Realist), Fang (the Apathetic), and Vanille and Sazh (the Conflicted).
Gears of War 2: Marcus (the Realist), Dom and Cole (the Optimist), Baird (the Cynic), Dizzy (the Apathetic).
Half-Life 2: Barney Calhoun (the Cynic), Alyx Vance (the Optimist), Dr. Kleiner (the Realist), and Dr. Mossman (the Apathetic).
The first Knights of the Old Republic: Carth's a Cynic. Mission is very much an Optimist. Canderous is Apathetic (a Mandalorian on a boatload of Jedi and Republic sympathizers, and has nothing better to do). Bastila looks like a Realist, but is actually Conflicted. Juhani appears Conflicted, but bends more Realist. Zaalbar is also Conflicted (you can influence him to the Dark Side pretty easily). The droids are Apathetic (T3 hasn't lived long enough to develop a personality; HK-47 just wants to shoot things for the meatbag in charge). Jolee likes to ride the line between Cynic and Apathetic.
Left 4 Dead: Francis who hates everything (the Cynic), hopeful Louis (the Optimist), Bill the experienced (the Realist), and, knowledgeable on zombies, Zoey (the Apathetic).
Left 4 Dead 2: pessimistic Nick (the Cynic), naive Ellis (the Optimist), Coach as leader (the Realist), and Rochelle, the only neutral character (the Apathetic
The Legend of Dragoon. Dart is the Realist, Lavitz is the Optimist, Rose is the Cynic, Shana is the Conflicted. Haschel later joins as the Apathetic. This setup holds from the time Rose joins all the way until Dragoon's It Was His Sled moment happens, where it transitions into a proper Five-Man Band.
Mega Man Zero — Among the Four Guardians, plus their master in the first game: Copy-X (the Cynic), Phantom (the Apathetic, although pragmatic), Harpuia (the Conflicted), Fefnir (the Optimist), and Leviathan (the Realist).
Metroid Prime 3: Corruption: Samus (the Conflicted, sometimes the Realist), Ghor (the Cynic, sometimes Conflicted), Gandrayda (the Optimist), and Rundas (the Apathetic and pragmatist).
The playable characters of the Touhou Project: Reimu (the Cynic), Marisa (the Realist), Sanae (the Optimist), and Sakuya and Youmu taking turns being the Apathetic.
The Star Fox team. There's Falco (Cynic), Slippy (Optimist), Peppy (Realist) and Fox (Conflicted). When Krystal replaces Peppy in later games, she fills the Conflicted spot with Fox becoming more of a Realist.
The boys in Nameless: Lance (the Cynic), Red (the Optimist), Tei (the Realist), Yuri (the Apathetic — he does care but either expects things to work themselves out or acts without consulting the others) and Yeonho (the Conflicted).
This actually becomes a gameplay mechanic in This War of Mine when it comes to emotion levels; The Optimist is much more eligible for mood swings than The Cynic, and the more emotional characters are better at curing depression.
The Realist: Marko, Pavle, Katia
The Cynic: Roman, Bruno, Emilia
The Optimist: Zlata, Boris, Cveta
The Apathetic: Marin, Arica, Anton
All of the opposing and antithetical factions in Fallout 4:
The Optimist: The Minutemen, as their original goal was to protect settlements out of good will but they were nearly wiped out after a string of bad luck. They can make a comeback and they are even more idealistic than ever despite all the shit they've been dragged through. They're flexible on policy when it comes to the Synths.
The Cynic: The Institute, as they believe that it is futile to allow the Commonwealth to continue existing and want to start anew in a new society underground. However, the same people they claim to want to help fear them due to many of their own actions. To them, the Synth is Just a Machine.
The Apathetic: The Railroad views the Synths as living, thinking beings worthy of respect, and wants to liberate all Synths from the Institute. The problem is that this is their ONLY goal and they don't really care about anyone else in the Commonwealth.
The Realist: The Brotherhood of Steel. Ten years after the war with the Enclave, the original teachings of Elder Lyons have been lost since his death and the death of his daughter, Sarah Lyons. Arthur Maxson is in charge and wants to try and expand into the Commonwealth to oppose the Institute. To them, Synths are abominations against technology and to be destroyed down to the last.