Five Bad Band: Video Games M-R
- Makai Toshi Sa Ga (a.k.a. Final Fantasy Legend)
- Manhunt 2
- The Masters of Evil in Marvel Ultimate Alliance
- Marvel vs. Capcom 3: Fate Of Two Worlds
- Mass Effect:
- Mass Effect 2 doesn't have one of these, with there being only one main antagonist, Harbinger, who uses the Collector General as a mouthpiece. However, the mercenary groups that team up against Archangel have leaders that fit this mold nicely.
- There's also the Shadow Broker in Mass Effect 2.
- Cerberus in Mass Effect 3
- Max Payne
- Max Payne 3
- The FM-ians in Mega Man Star Force:
- The Neo Mu Empire in Mega Man Star Force 2:
- Dealer in Mega Man Star Force 3:
- Mega Man X3:
- Mega Man X6:
- Mega Man X: Command Mission
- Mega Man Zero: Copy X and the Four Guardians (although the latter aren't actually "villains")
- Mega Man Zero 3:
- Mega Man ZX Advent:
- Metal Gear Solid's Fox-Hound:
- Metal Gear Solid 2: Sons of Liberty's Sons Of Liberty:
- Metal Gear Solid 3: Snake Eater's main bad guys:
- The Cobras in more detail (formerly a Five-Man Band)
- Metal Gear Solid 4: Guns of the Patriots's B&B Corp A.K.A. Snakehound
- Metal Gear Rising: Revengeance's Desperado Enforcement LLC.
- Super Metroid:
- MOTHER 3: The Pigmask Army
- Need for Speed: Carbon - Stacked Deck
- Nicktoons Unite
- Nicktoons Attack of the Globs
- Ninja Gaiden:
- No One Lives For Ever (the first game)
- Nostalgia. The Ancient Father's Cabal:
- The Magog Cartel from Oddworld:
- The Oni bosses from Ōkami
- The Big Bad / The Brute: Blinky (chases Pac-Man)
- The Dragon: Inky (follows and aids Blinky)
- The Evil Genius: Pinky (tries to trap Pac-Man)
- The Dark Chick: Clyde (flees from Pac-Man); Sue serves as this in Ms. Pac-Man, as is Tim in Pac-Man Junior
- The Sixth Ranger: Funky and Spunky (jumping ghosts in Pac-Mania) and Kinky (can merge with other ghosts to make them stronger; a secondary Evil Genius exclusive to Pac-Man Arrange)
- Paper Mario
- Paper Mario: The Thousand-Year Door
- Persona 3
- Persona 4
- The Cipher Admins (and their superiors) in Pokémon Colosseum
- The Cipher Admins in Pokémon XD: Gale of Darkness
- Team Galactic In Pokémon Platinum
- Team Dim Sun from Pokémon Ranger: Shadows of Almia. It's scary how well they fit their respective parts.
- Neo Team Rocket from Pokémon HeartGold & SoulSilver.
- The Big Bad - Giovanni, as event Celebi shows.
- The Dragon - Archer, the final executive, who disbands Team Rocket.
- The Evil Genius - Petrel, the master of disguise.
- The Brute - Proton, who is "often labeled as the scariest and cruelest guy in Team Rocket".
- The Dark Chick - Ariana, though she introduces herself as "interim boss in the place of Giovanni", Archer seems to be the true leader of executives.
- Team Plasma in Pokémon Black and White
- Neo Team Plasma in Pokémon Black 2 and White 2
- The Societea in Pokémon Ranger: Guardian Signs
- Police 911 - The Gokudo-kai
- Prince of Persia (2008)
- Prototype: Blackwatch
- Prototype 2: Evolved
- Psychic Force 2012: The Psychiccer Army
- Ratchet: Deadlocked:
- Ratchet & Clank Future: A Crack In Time:
- Red Dead Redemption -Dutch's old gang
- Red Dead Redemption -The Mexican Army
- Red Faction II, after Molov's Face-Heel Turn:
- Resident Evil series: Umbrella
- Resident Evil 2
- Resident Evil 4:
- Return to Castle Wolfenstein
- Resident Evil: Operation Raccoon City: Umbrella Security Service
- Romancing Sa Ga 2
- Romancing Sa Ga 3
- Rosenkreuzstilette Freudenstachel - The Black Cross
- The Red Crayon Aristocrats in Rule of Rose