The Frightful Four 2099 seen in Fantastic Four 2099UGR not only plays the trope straight, but plays with it as well. For starters, they can't stand being called the Frightful Four (even though that nickname is applied to them), as their goal is to usurp the team name Fantastic Four from the current bearers of that name (four clones of the original FF team). Second, they're all Mad Scientists, so they all share the Evil Genius trope.
The Big Bad - Ian "Fantastic" Hyde, whose speed and strength finally match the size of his ego.
The Dragon - Jesse "Invisible" Stamp. He starts off as a shy introvert who has difficulty with eye contact. Once he develops the power to edit himself from the perceptions of other people and electronic equipment, his confidence and sadism grow (now that nobody's looking at him). His rivalry with Ian Hyde (especially over the affections of Michaela Bailey) grows as well, to the point that he openly challenges Hyde for leadership.
The Dark Chick - Michaela "Thing" Bailey. She shapeshifts different parts of her body into that of different members of the animal kingdom, but her inability to revert to human form causes her to consider herself the Freak of the group. Her relationship with Ian Hyde becomes a focal point of his rivalry with Jesse Stamp.
The Evil Genius - Everyone on the team, as they're rogue geneticists who have been dealing under-the-table with organleggers for years. But Ian Hyde is convinced he's far more brilliant than the rest of them.
The Brute - Christi "Torch" Wood. This has nothing to do with her physical stature (she's petite), and everything to do with her ability to cause intense agony in the minds of others. She even uses this ability on members of her own team when they annoy her, but for the most part she's content to be a team player.
The wrestlers in the Battle Royale based 72 Hours fit the idea, though two of them are clearly not actually evil and a third doesn’t even have a personality at all to speak of. Nevertheless, the group as a whole are one of four sets of primary antagonists (the other three each being a single individual acting independantly).
Big Bad: Joel, who leaves no question as to who’s in charge.
The Dragon: Mike V, well established as Joel’s second in command, and one of few in the class whose sadism rivals Joel's.
Dark Chick: Extreme Doormat C.C., who is utterly devoid of personality and only there to be a sexual plaything for Joel
The Brute: Poor Shane. Effectively a living brick Joel throws at things that need beaten up, or killed in the case of the Program.
Big Bad: Nightshade, a former Wonderbolt who got impatient for the chance to prove her worth, mucked up badly, and now 'wants to get back at the foals for holding her down'.
