Used straight in this strip of Loserz, in which a fat guy rants to shift the blame of his obesity on restaurants and other sources of high-fat foods (The previous strip which he refers to has Eric mentioning how unhealthy food is cheaper).
Tharqa from Penny and Aggie practically defines this trope. The only overweight character in the entire strip, and she couldn't be more venial. Karen, while having lost weight and shaped up considerably, is still bigger than every other character except Tharqa, and is well on her way to becoming the Big Bad of the comic with her Machiavellian plans against the titular characters.
Averted with Sidney Burns of Mob Ties. Enormously fat, but still the most heroic and driven of the psychotic cast.
The Inexplicable Adventures of Bob!: Emperor Krelchzeeber, the guy who killed Riboflavin's dad. Nemesites are butterfly people, and therefore normally very skinny with big wings; not so with Krelchzeeber.
Starfish from Unsounded, the pedophilic, Jerkass leader of the Red Berry Boys, he has people kidnapped so their organs can be cut out and the extra space used to smuggle an illegal substance inside their bodies. His weight and appetite is frequently commented on and mocked by other characters.