In Anathema, shrouds with the dominion of Despair can drive others to suicide, even if that person was perfectly fine before.
If a shroud has the primary dominion of Despair, it means that their husk committed suicide.
In the origin story for the Ravenloft setting, grieving bride Tatyana throws herself from the clifftop castle wall, rather than be turned into a vampire by her fiance's murderous brother, Strahd von Zarovich. Strahd's karmic punishment as a Darklord is to continue driving Tatyana's reincarnations to suicide (or be otherwise directly or indirectly responsible for her death) again and again as the only thing he truly wants - her - keeps slipping from his grasp.
One of the Deathlords in Exalted, during his first life as a Solar Exalted, was inducted into a Circle (adventuring party) to replace their lost member, who had carried the same Shard. After enduring a decade of them demonstrating why the Solars ended up being overthrown, he killed himself. Then, after spending a fair while as a brooding ghost, the rest of them managed what he saw as a Karma Houdini...so now he wants to destroy all life.
For a while in Warhammer 40,000 it was possible for a Commissar of the Imperial Guard to execute himself. This was quickly patched in the Codex's FAQ.