This one's pure easy. Just drink whenever:
- The signature 'dah dah da-da-daaaah' plays.
- Someone presses a button. Continuous typing counts as one press - if they stop and start again you have to drink again. When someone presses a single button multiple times, each press counts.
- A door opens or closes. This applies to both manual doors and powered ones.
- An explosion occurs.
- When anyone says the word "special". Do this and get drunk in first 10 minutes.
- And, as in universe, whenever they run, take a shot.
- When the In-Universe drinking game shows up, take a shot.
If you feel like just one long draft for this, then this video
has got you covered.