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Drink at every Michael Jackson/zombie movie reference you can find during Thriller Bark.
Drink every time they make a joke about Luffy and meat. That includes hungry jokes, manic eating, "I want food", and the like.
Drink at every new Devil Fruit the show introduces.
Drink every time a named character doesn't die when they should have (powerful attacks, No One Could Survive That, stuff). Drink twice if someone actually dies.
If ever a part of the song Binks' Sake is sung, pause the episode/chapter, pour a full glass, find the song and do your best to sing along while taking a swig every so often. If you still have some left when it's done, drain the glass.
Drink every time the strawhats fight amongst each other. Drink again if it's not Zoro and Sanji who are fighting.
Hard Mode: Drink every time the straw hats fight amongst each other, and it is NOT Played for Laughs.
Drink every time someone says nakama. Dub notwithstanding.
Drink every time someone has a demon head and yells at someone else for doing/saying something stupid. Drink twice if it's not Nami.
Pour a full glass and drink the whole thing every time a character mows down a huge bunch of enemies. Do only half a glass if it's Luffy mowing them down. This could save your life when you get to the Enies Lobby arc.
Drink every time Brook jokes about not having the body part he just referred to and laughs afterwards. Two if he says, "SKULL JOKE!" Three each time he laughs "Yohohohoho!!"
Drink every time Brook asks to see someone's panties.
Drink every time Ace acts like a Wangst or makes crying/choking noises during Marineford.
Take another sip if the screen has to wind back and show said fault is coming from a character in the foreground from a corner yelling at another character's idiocy in annoyance.
Another if they smack their hand back and it makes a slapping sound.
Another if you hear an abrupt trumpet (BA-DUHH!!) as the scene focuses on the idiocy or the annoyed character(s) watching said idiocy. A sip for any other goofy sound effect, because the trumpet is the most prevalent.
Impossible Rule: In the highly unlikely, rarest of rare events that Robin has a Wild Take- a real one- take TEN THOUSAND SHOTS.
Finish your drink if Usopp inserts a "Rubber Band of Doom" into one of his relentless attacks.
Take a shot every time Zoro and Sanji argue. Two if Sanji calls Zoro "Moss Head".
Take a shot any time Nami gets pissed. Two if someone gets hit. Three if it's Luffy or Zoro.
Take a shot any time Nami makes someone pay a debt to her or mentions that doing something is going to cost them a high price of Berries. Two if it has insane interest or she brings it up repeatedly. Three if she cons someone out of money.
Drink whenever Nami gets excited at the mere mention of money or treasure.
Take a drink whenever Nami uses her Clima Tact and makes a weather forecast. Two if it does something she did not expect it to.
Take a sip any time Sanji hits on a female. Two if it's someone he just met. Three if it's perverted. Three and a half if it's Vivi. Four if it's Robin. Five if it's Nami. Six if he calls Nami "Mellorine". Seven if he gets a nosebleed. Eight if Zoro deflates him. Nine if Sanji actually cringes at an ugly woman and/or okama. And to round it all off, a good ten sips if Sanji's has pink heart eyes and/or his cigarette smoke fume puffs turn into hearts. Ah, what the hell- let's go Up to Eleven. Take eleven sips any time Sanji has a fantasy about a woman, rapid-fire if it involves Nami and/or Robin.
Take a drink if Sanji's crappy wanted poster comes up in conversation.
Take a shot whenever Sanji lights up a cigarette.
Take a shot any time Luffy says something is a "mystery".
Finish your drink any time someone compliments Chopper and he tries not to be bashful about it by saying it doesn't flatter him, when in reality, he's doing a Happy Dance and is obviously lying about it.
Take a shot any time Robin has a Nightmare Fetishist moment. Two if she gets angry at Franky's antics.
Take a shot any time Robin is reading a book. Two if she is reclining in a deck chair while doing so.
Similarly, take a shot any time Nami is relaxing in a deck chair. Two if she's sunbathing. Three if she's so relaxed she's kicked her shoes off. Four if she's in a bikini top.
Take half a shot any time Nami changes wardrobe. A full one if she has on a new shirt with a word emblazoned across it, wears a new pair of shoes (almost always sandals, but she likes boots every now and then, so we'll go with shoes), or dons a new hairstyle (pins it up, pigtails, glasses, longer, etc).
Two if you think her boob size increased since the last episode, or her outfit is comparably skimpier. Action Dress Rip counts.
Take a shot any time Franky yells, "SUPER!!" Two if he does the forearm star tattoo pose. Three if he starts dancing.
Take a sip for each unique function Franky exhibits on his cyborg body per episode, or new weapon, vehicle, robot, etc. Another if it's brand new. Two if it's really vulgar. Three if it's just plain silly.
Take three drinks any time Zoro acquires a new scar.
During the G-8 filler arc, take a shot every time Inspector Shepherd is refered to as "Condoriano".
Drink any time Chopper freaks out. Twice if he forgets he's a doctor. Thrice if he jumps into water and forgets he can't swim.
While Usopp is posing as Sogeking (Sniper King), take a drink every time he goes into his alter ego persona. Another if he says Sniper Island is in your heart. Another if he does his Sogeking theme song. Another if Usopp reverts back to his cowardly true personality and drops the act- or gets so annoyed that he starts screaming at someone in his own voice.
Take a sip for every unique laugh you hear from a character.
Take a drink every time Spandam has a clumsy moment. Two if he gets hit with something and/or struck by somebody. Three if it's in the face. Four if he deserved it.
Any time Luffy, Usopp, or Chopper have a Bishie Sparkle moment at the sight of something incredibly awesome, have a sparkling drink.
Finish your drink if Sanji re-arranges someone's face.
If Franky puts on pants, stop drinking.
Sip for every individual appendage Robin generates with her Hana Hana No Mi powers.
Drink whenever Tashigi falls over.
Drink any time Hina refers to herself in the third person.
Pound your drink down whenever Whitebeard mops the floor with someone.
Drink any time Shanks is shown drinking. Two if the whole crew is drinking.
Take a drink whenever Peeply Lulu pushes on his cowlick and it just pops up somewhere else on his head. Two if it ends up somewhere else on his body. Three if it migrates to someone else's body.
Take a drink whenever Paulie freaks out at a scantily clad woman and calls them a harlot or immoral. Two if it's Nami- two and a half if he says "Harlot Girl/Immoral Girl".
Finish four drinks when the Straw Hats celebrate a party after defeating a particularly powerful group of enemies. Throw in a fifth if there is a scene that shows everyone crashed out after partying all night.
Any time Sanji refers to something as "crappy", take a crappy drink.
And finally, take a light sip any time you see Kokoro drinking or visibly drunk with blushes on her face. Any more and you will pickle your insides.