In the Out of This World playthrough, take a shot for each "mycaruba" or a variant thereof.
Take a shot whenever a dick/fart/poop joke is made.
Down half the bottle if two out of the three concepts are used in the same joke.
Down the whole bottle if all three concepts are used in the same joke.
Take a shot whenever Danny's Judaism is referenced.
Take two shots if Arin uses that knowledge against him.
Drink every time Danny does an impression of his father.
Drink whenever Arin beatboxes.
Take a shot every time Arin uses George for someone's name.
Take an extra if he uses Franklin after using George.
Drink every time Arin tells an enemy to "chill the fuck out".
Take a shot whenever Dan shouts " We're playing the feud!".
Take a shot whenever Arin dismisses control guides or general game instructions.
Take two shots if this causes him to be confused or lost.
Down the bottle if he then blames the game.
Take a shot each time Danny yells, "Son of a bitch!" or "You son of a bitch!"
Finish your drink whenever Danny starts singing in the middle of a Game Grumps episode. If he's singing Ninja Sex Party song lyrics, add another shot. If he includes a Starbomb song, a full drink and two shots.
During the Battle Kid: Fortress of Peril finale, take a sip each time Arin gets killed by the Lotus Guardian. Taking shots, as Danny warns, could put you in the hospital.
Take a shot whenever Danny says "in the 80s" or mentions anything from the 80s.
Finish your drink if Arin starts coughing after laughing too hard. The same goes for Jon. Be careful if you're watching videos from around that time they got really nasty food poisoning at MAGFest, which made them so sick they kept hacking and coughing for a very long time.
Alternatively: finish your drink if Danny starts gasping for air after laughing too hard.
Finish your drink if Arin does something that makes Danny comment, "So stupid..."
For the Sonic Boom playthrough, take a shot each time Arin abuses Knuckles's infinite jump glitch. Another shot any time Danny groans in tired disapproval at him for making the playthrough cheap.